Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Anterior cingulate cortex neuro-metabolic changes underlying lithium-induced euthymia in bipolar depression: A longitudinal H-1-MRS study

Full text
Author(s):
Soeiro-de-Souza, M. G. [1] ; Scotti-Muzzi, E. [1] ; Fernandes, F. [1] ; De Sousa, R. T. [1] ; Leite, C. C. [2] ; Otaduy, M. C. [2] ; Machado-Vieira, R. [3]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Sch Med, Dept & Inst Psychiat, Sao Paulo - Brazil
[2] Univ Sao Paulo InRad FMUSP, Lab Magnet Resonance LIM44, Dept & Inst Radiol, Sao Paulo - Brazil
[3] Univ Texas, Austin, TX - USA
Total Affiliations: 3
Document type: Journal article
Source: European Neuropsychopharmacology; v. 49, p. 93-100, AUG 2021.
Web of Science Citations: 0
Abstract

The diagnosis and treatment of bipolar depression (BDep) poses complex clinical challenges for psychiatry. Proton magnetic resonance spectroscopy (H-1-MRS) is a useful imaging tool for investigating in vivo levels of brain neuro-metabolites, critical to understanding the process of mood dysregulation in Bipolar Disorder. Few studies have evaluated longitudinal clinical outcomes in BDep associated with H-1-MRS metabolic changes. This study aimed to longitudinally assess brain H-1-MRS metabolites in the anterior cingulate cortex (ACC) correlated with improvement in depression (from BDep to euthymia) after lithium treatment in BDep patients versus matched healthy controls (HC). Twenty-eight medication-free BDep patients and 28 HC, matched for age and gender, were included in this study. All subjects were submitted to a 3-Tesla brain H-1-MRS scan in the ACC using a single-voxel (8cm(3)) PRESS sequence at baseline. At follow-up (6 weeks), 14 BDep patients repeated the exam in euthymia. Patients with current BDep had higher baseline Myo-inositol/Cr (mI/Cr) and Choline/Cr (Cho/Cr) compared to HC. After six weeks, mI/Cr or Cho/Cr levels in subjects that achieved euthymia no longer differed to levels in HC, while high Cho/Cr levels persisted in non-responders . Elevated ACC mI/Cr and Cho/Cr in BDep might indicate increased abnormal membrane phospholipid metabolism and phosphatidylinositol (PI) cycle activity. Return of mI/Cr and Cho/Cr to normal levels after lithium-induced euthymia sug-gests a critical regulatory effect of lithium targeting the PI cycle involved in mood regulation. (C) 2021 Elsevier B.V. and ECNP. All rights reserved. (AU)

FAPESP's process: 10/12286-8 - Genetic association study between single nucleotide polymorphism and cognitive performance in young bipolar I patients: Licavalgene
Grantee:Márcio Gerhardt Soeiro-de-Souza
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 12/23796-2 - "Genetic association study between cognitive performance, polymorphisms of GAD1/Reelin and 3T magnetic ressonance spectroscopy of GABA/glutamate in bipolar I disorder and healthy controls"
Grantee:Márcio Gerhardt Soeiro-de-Souza
Support type: Scholarships in Brazil - Post-Doctorate