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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Anterior cingulate cortex neuro-metabolic changes underlying lithium-induced euthymia in bipolar depression: A longitudinal H-1-MRS study

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Soeiro-de-Souza, M. G. [1] ; Scotti-Muzzi, E. [1] ; Fernandes, F. [1] ; De Sousa, R. T. [1] ; Leite, C. C. [2] ; Otaduy, M. C. [2] ; Machado-Vieira, R. [3]
Total Authors: 7
[1] Univ Sao Paulo, Sch Med, Dept & Inst Psychiat, Sao Paulo - Brazil
[2] Univ Sao Paulo InRad FMUSP, Lab Magnet Resonance LIM44, Dept & Inst Radiol, Sao Paulo - Brazil
[3] Univ Texas, Austin, TX - USA
Total Affiliations: 3
Document type: Journal article
Source: European Neuropsychopharmacology; v. 49, p. 93-100, AUG 2021.
Web of Science Citations: 0

The diagnosis and treatment of bipolar depression (BDep) poses complex clinical challenges for psychiatry. Proton magnetic resonance spectroscopy (H-1-MRS) is a useful imaging tool for investigating in vivo levels of brain neuro-metabolites, critical to understanding the process of mood dysregulation in Bipolar Disorder. Few studies have evaluated longitudinal clinical outcomes in BDep associated with H-1-MRS metabolic changes. This study aimed to longitudinally assess brain H-1-MRS metabolites in the anterior cingulate cortex (ACC) correlated with improvement in depression (from BDep to euthymia) after lithium treatment in BDep patients versus matched healthy controls (HC). Twenty-eight medication-free BDep patients and 28 HC, matched for age and gender, were included in this study. All subjects were submitted to a 3-Tesla brain H-1-MRS scan in the ACC using a single-voxel (8cm(3)) PRESS sequence at baseline. At follow-up (6 weeks), 14 BDep patients repeated the exam in euthymia. Patients with current BDep had higher baseline Myo-inositol/Cr (mI/Cr) and Choline/Cr (Cho/Cr) compared to HC. After six weeks, mI/Cr or Cho/Cr levels in subjects that achieved euthymia no longer differed to levels in HC, while high Cho/Cr levels persisted in non-responders . Elevated ACC mI/Cr and Cho/Cr in BDep might indicate increased abnormal membrane phospholipid metabolism and phosphatidylinositol (PI) cycle activity. Return of mI/Cr and Cho/Cr to normal levels after lithium-induced euthymia sug-gests a critical regulatory effect of lithium targeting the PI cycle involved in mood regulation. (C) 2021 Elsevier B.V. and ECNP. All rights reserved. (AU)

FAPESP's process: 10/12286-8 - Genetic association study between single nucleotide polymorphism and cognitive performance in young bipolar I patients: Licavalgene
Grantee:Márcio Gerhardt Soeiro-de-Souza
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 12/23796-2 - "Genetic association study between cognitive performance, polymorphisms of GAD1/Reelin and 3T magnetic ressonance spectroscopy of GABA/glutamate in bipolar I disorder and healthy controls"
Grantee:Márcio Gerhardt Soeiro-de-Souza
Support type: Scholarships in Brazil - Post-Doctorate