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Genetic association study between single nucleotide polymorphism and cognitive performance in young bipolar I patients: Licavalgene

Grant number: 10/12286-8
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): October 01, 2010
Effective date (End): March 31, 2013
Field of knowledge:Health Sciences - Medicine - Psychiatry
Principal researcher:Ricardo Alberto Moreno
Grantee:Márcio Gerhardt Soeiro-de-Souza
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Introduction: cognition is a complex function influenced by a number of genes, each with a small role. The performance in each cognitive domain can be statistically associated to the activity of certain proteins and by that through genetic variations responsible for theses functional differences. The patients with bipolar disorder present serious dysfunctions during phases of mania, depression and mixed states. Nowadays we work with the hypothesis that exist a group of patients with similar genetic features that present a worse cognitive decline during the course of the illness. The genes most associated to cognitive function are catecol-o-metiltransferase, apolipoprotein E and brain derived neurotrophic protein. Our objective is to look for an association between cognitive performance and genotype of COMT, APOE and BDNF during the symptomatic phase of the disease. Methods: 80 symptomatic patients bipolar Type I, free of medication, age 18-35 years old and 60 healthy controls will go through complete cognite evaluation and genotyping for COMT, APOE and BDNF. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SOEIRO-DE-SOUZA, M. G.; SCOTTI-MUZZI, E.; FERNANDES, F.; DE SOUSA, R. T.; LEITE, C. C.; OTADUY, M. C.; MACHADO-VIEIRA, R. Anterior cingulate cortex neuro-metabolic changes underlying lithium-induced euthymia in bipolar depression: A longitudinal H-1-MRS study. European Neuropsychopharmacology, v. 49, p. 93-100, AUG 2021. Web of Science Citations: 0.
SCOTTI-MUZZI, ESTEVAO; CHILE, THAIS; MORENO, RICARDO; PASTORELLO, BRUNO FRACCINI; LEITE, CLAUDIA DA COSTA; HENNING, ANKE; GARCIA OTADUY, MARIA CONCEPCION; VALLADA, HOMERO; SOEIRO-DE-SOUZA, MARCIO GERHARDT. ACC Glu/GABA ratio is decreased in euthymic bipolar disorder I patients: possible in vivo neurometabolite explanation for mood stabilization. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, v. 271, n. 3 JAN 2020. Web of Science Citations: 1.

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