Nanosystem functionalization strategies for prostate cancer treatment: a review

Autor(es)

de Araujo, Jennifer Thayanne Cavalcante ^[1] ; Duarte, Jonatas Lobato ^[1] ; Di Filippo, Leonardo Delello ^[1] ; Araujo, Victor Hugo Sousa ^[1] ; Carvalho, Gabriela Correa ^[1] ; Chorilli, Marlus ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Drugs & Pharmaceut, BR-14800903 Araraquara, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Journal of Drug Targeting; v. 29, n. 8, p. 808-821, SEP 14 2021.
• Citações Web of Science: 2

Resumo

Prostate cancer (PC) has a high morbidity and mortality rate worldwide, and the current clinical guidelines can vary depending on the stage of the disease. Drug delivery nanosystems (DDNs) can improve biopharmaceutical properties of encapsulated anti-cancer drugs by modulating their release kinetics, improving physicochemical stability and reducing toxicity. DDN can also enhance the ability of specific targeting through surface modification by coupling ligands (antibodies, nucleic acids, peptides, aptamer, proteins), thus favouring the cell internalisation process by endocytosis. The purposes of this review are to describe the limitations in the treatment of PC, explore different functionalization such as polymeric, lipid and inorganic nanosystems aimed at the treatment of PC, and demonstrate the improvement of this modification for an active target, as alternative and promising candidates for new therapies. (AU)

• Processo FAPESP: 18/18488-3 - Avaliação do potencial de carreadores lipídicos nanostruturados funcionalizados com bevacizumab para veiculação de docetaxel no tratamento de glioblastoma
• Beneficiário: Leonardo Delello Di Filippo
• Modalidade de apoio: Bolsas no Brasil - Mestrado