Biopolymer-based microparticles for encapsulation of all-trans-retinoic acid

Autor(es)

Silva, Leticia A. ^[1] ; Dambros, Roberta ^[1] ; Leonardi, Gislaine R. ^[2] ; Perrechil, Fabiana ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo UNIFESP, Dept Engn Quim, Diadema, SP - Brazil

^[2] Univ Estadual Campinas, Fac Pharmaceut Sci, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Applied Polymer Science; v. 138, n. 45 DEC 5 2021.
• Citações Web of Science: 0

Resumo

This work aims to investigate the potential of complex coacervation technique to encapsulate and protect all-trans retinoic acid (RA). Gelatin and kappa-carrageenan were used as wall material and pequi oil was employed as a hydrophobic phase. Three formulations with different protein: polysaccharide ratio and pH were defined to produce the microparticles based on the zeta potential and turbidity analysis: (F1) ratio 3:1 and pH 3.5, (F2) ratio 8:1 and pH 3.5, and (F3) ratio 8:1 and pH 5.0. Microparticles were evaluated regarding their morphology, yield, encapsulation efficiency (EE), and stability. The properties of microparticles were mainly affected by the protein: polysaccharide ratio and the turbidity of the mixtures, which is directly related to the protein-polysaccharide interaction. Formulation 1 showed the optimal values of yield (75.6%), EE (100.2%), and stability (85% of the encapsulated RA remained in the particle). The results demonstrated the high potential of this innovative technique to encapsulate RA for a future application in topical formulations. (AU)

• Processo FAPESP: 15/02129-6 - Desenvolvimento e avaliação de sistemas de liberação de ácido retinóico constituídos por micropartículas de k-carragena veiculadas em emulsões providas, ou não, de estruturas líquido-cristalinas
• Beneficiário: Gislaine Ricci Leonardi
• Modalidade de apoio: Auxílio à Pesquisa - Regular