| Full text | |
| Author(s): |
Total Authors: 4
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| Affiliation: | [1] Univ Fed Sao Paulo UNIFESP, Dept Engn Quim, Diadema, SP - Brazil
[2] Univ Estadual Campinas, Fac Pharmaceut Sci, Campinas, SP - Brazil
Total Affiliations: 2
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| Document type: | Journal article |
| Source: | Journal of Applied Polymer Science; v. 138, n. 45 DEC 5 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
This work aims to investigate the potential of complex coacervation technique to encapsulate and protect all-trans retinoic acid (RA). Gelatin and kappa-carrageenan were used as wall material and pequi oil was employed as a hydrophobic phase. Three formulations with different protein: polysaccharide ratio and pH were defined to produce the microparticles based on the zeta potential and turbidity analysis: (F1) ratio 3:1 and pH 3.5, (F2) ratio 8:1 and pH 3.5, and (F3) ratio 8:1 and pH 5.0. Microparticles were evaluated regarding their morphology, yield, encapsulation efficiency (EE), and stability. The properties of microparticles were mainly affected by the protein: polysaccharide ratio and the turbidity of the mixtures, which is directly related to the protein-polysaccharide interaction. Formulation 1 showed the optimal values of yield (75.6%), EE (100.2%), and stability (85% of the encapsulated RA remained in the particle). The results demonstrated the high potential of this innovative technique to encapsulate RA for a future application in topical formulations. (AU) | |
| FAPESP's process: | 15/02129-6 - DEVELOPMENT AND EVALUATION OF RETINOIC ACID DRUG DELIVERY SYSTEMS PROVIDED BY MICROPARTICLES OF K-CARRAGEENAN IN EMULSIFIED SYSTEMS CONSTITUTED, OR NOT, OF LIQUID CRISTALLINE STRUCTURES |
| Grantee: | Gislaine Ricci Leonardi |
| Support Opportunities: | Regular Research Grants |