Grant number: | 15/02129-6 |
Support Opportunities: | Regular Research Grants |
Start date: | February 01, 2016 |
End date: | April 30, 2018 |
Field of knowledge: | Health Sciences - Pharmacy |
Principal Investigator: | Gislaine Ricci Leonardi |
Grantee: | Gislaine Ricci Leonardi |
Host Institution: | Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil |
Associated researchers: | Fabiana Perrechil Bonsanto |
Abstract
Retinoic acid has been used in several clinical applications and skin disorders such as psoriasis, anti-aging treatment, acne, dyschromias and as a cell renewal agent treatment. Regardless of the application, the problems involving this drug can be understood through two perspectives: first, it refers to an intrinsic molecular property, represented by its instability, because this drug is highly susceptible to oxidation. The second problematic aspect of this therapeutic compound is related to the high incidence of adverse effects that may impair the therapeutic treatment. Therefore, this research aims to develop biopolymeric microparticles composed by K-carrageenan containing retinoic acid, and incorporate it into traditional systems and liquid crystalline systems, to obtain more stable and effective dermatological products with a possibility to minimize the risk of skin irritation due to gradual and prolonged drug release. Furthermore, passive and iontophoretic permeation studies of retinoic acid, microencapsulated in formulations, will be carried out to recognize the permeation profile of this drug and also seeks to explore the target iontophoretic action (direct action to specific layers of the skin) of the retinoic acid, which can ensure a lower chance of systemic absorption and better topical efficacy. (AU)
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