DEVELOPMENT AND EVALUATION OF RETINOIC ACID DRUG DELIVERY SYSTEMS PROVIDED BY MICROPARTICLES OF K-CARRAGEENAN IN EMULSIFIED SYSTEMS CONSTITUTED, OR NOT, OF LIQUID CRISTALLINE STRUCTURES

• Grant number: 15/02129-6
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2016
• End date: April 30, 2018
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Gislaine Ricci Leonardi
• Grantee: Gislaine Ricci Leonardi
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated researchers: Fabiana Perrechil Bonsanto

Abstract

Retinoic acid has been used in several clinical applications and skin disorders such as psoriasis, anti-aging treatment, acne, dyschromias and as a cell renewal agent treatment. Regardless of the application, the problems involving this drug can be understood through two perspectives: first, it refers to an intrinsic molecular property, represented by its instability, because this drug is highly susceptible to oxidation. The second problematic aspect of this therapeutic compound is related to the high incidence of adverse effects that may impair the therapeutic treatment. Therefore, this research aims to develop biopolymeric microparticles composed by K-carrageenan containing retinoic acid, and incorporate it into traditional systems and liquid crystalline systems, to obtain more stable and effective dermatological products with a possibility to minimize the risk of skin irritation due to gradual and prolonged drug release. Furthermore, passive and iontophoretic permeation studies of retinoic acid, microencapsulated in formulations, will be carried out to recognize the permeation profile of this drug and also seeks to explore the target iontophoretic action (direct action to specific layers of the skin) of the retinoic acid, which can ensure a lower chance of systemic absorption and better topical efficacy. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

POMPEU RAMINELLI, ANA CLAUDIA; ROMERO, VALERIA; SEMREEN, MOHAMMAD H.; LEONARDI, GISLAINE RICCI. Nanotechnological Advances for Cutaneous Release of Tretinoin: An Approach to Minimize Side Effects and Improve Therapeutic Efficacy. Current Medicinal Chemistry, v. 25, n. 31, p. 3703-3718, 2018. (15/02129-6, 13/01118-5)

POMPEU RAMINELLI, ANA CLAUDIA; RODRIGUES-OLIVEIRA, ANDRE FELIPE; YOKOTA, RODRIGO; SUMITA, JULIANA MAYUMI; OLIVEIRA-SILVA, DIOGO; WAMBIER, CARLOS GUSTAVO; BAGATIN, EDILEIA; LEONARDI, GISLAINE RICCI. Cutaneous absorption of tretinoin in 0.05% cream and 5% chemical peel formulas. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, v. 83, n. 5, p. 1483-1485, NOV 2020. (13/01118-5, 15/02129-6)

MONTEIRO E SILVA, SILAS ARANDAS; RICCI LEONARDI, GISLAINE. Development and cathodic iontophoretic permeation evaluation of liquid crystalline systems provided of retinoic acid microparticles. Journal of Cosmetic Dermatology, v. 20, n. 7, NOV 2020. (15/02129-6)

DE OLIVEIRA, ERIKA C. V.; DA MOTTA, VALERIA R. V.; PANTOJA, PAOLA C.; ILHA, CAROLINA S. DE O.; MAGALHAES, RENATA F.; GALADARI, HASSAN; LEONARDI, GISLAINE R.. Actinic keratosis - review for clinical practice. INTERNATIONAL JOURNAL OF DERMATOLOGY, v. 58, n. 4, p. 400-407, APR 2019. (15/02129-6)

SILVA, LETICIA A.; DAMBROS, ROBERTA; LEONARDI, GISLAINE R.; PERRECHIL, FABIANA. Biopolymer-based microparticles for encapsulation of all-trans-retinoic acid. Journal of Applied Polymer Science, JUN 2021. (15/02129-6)

SILVA, LETICIA A.; DAMBROS, ROBERTA; LEONARDI, GISLAINE R.; PERRECHIL, FABIANA. Biopolymer-based microparticles for encapsulation of all-trans-retinoic acid. Journal of Applied Polymer Science, v. 138, n. 45, DEC 5 2021. (15/02129-6)