Advanced search
Start date
Betweenand
Related content

DEVELOPMENT AND EVALUATION OF RETINOIC ACID DRUG DELIVERY SYSTEMS PROVIDED BY MICROPARTICLES OF K-CARRAGEENAN IN EMULSIFIED SYSTEMS CONSTITUTED, OR NOT, OF LIQUID CRISTALLINE STRUCTURES

Grant number: 15/02129-6
Support type:Regular Research Grants
Duration: February 01, 2016 - April 30, 2018
Field of knowledge:Health Sciences - Pharmacy
Principal researcher:Gislaine Ricci Leonardi
Grantee:Gislaine Ricci Leonardi
Home Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Assoc. researchers:Fabiana Perrechil Bonsanto

Abstract

Retinoic acid has been used in several clinical applications and skin disorders such as psoriasis, anti-aging treatment, acne, dyschromias and as a cell renewal agent treatment. Regardless of the application, the problems involving this drug can be understood through two perspectives: first, it refers to an intrinsic molecular property, represented by its instability, because this drug is highly susceptible to oxidation. The second problematic aspect of this therapeutic compound is related to the high incidence of adverse effects that may impair the therapeutic treatment. Therefore, this research aims to develop biopolymeric microparticles composed by K-carrageenan containing retinoic acid, and incorporate it into traditional systems and liquid crystalline systems, to obtain more stable and effective dermatological products with a possibility to minimize the risk of skin irritation due to gradual and prolonged drug release. Furthermore, passive and iontophoretic permeation studies of retinoic acid, microencapsulated in formulations, will be carried out to recognize the permeation profile of this drug and also seeks to explore the target iontophoretic action (direct action to specific layers of the skin) of the retinoic acid, which can ensure a lower chance of systemic absorption and better topical efficacy. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVA, LETICIA A.; DAMBROS, ROBERTA; LEONARDI, GISLAINE R.; PERRECHIL, FABIANA. Biopolymer-based microparticles for encapsulation of all-trans-retinoic acid. Journal of Applied Polymer Science, v. 138, n. 45, . (15/02129-6)
MONTEIRO E SILVA, SILAS ARANDAS; RICCI LEONARDI, GISLAINE. Development and cathodic iontophoretic permeation evaluation of liquid crystalline systems provided of retinoic acid microparticles. Journal of Cosmetic Dermatology, v. 20, n. 7, . (15/02129-6)
DE OLIVEIRA, ERIKA C. V.; DA MOTTA, VALERIA R. V.; PANTOJA, PAOLA C.; ILHA, CAROLINA S. DE O.; MAGALHAES, RENATA F.; GALADARI, HASSAN; LEONARDI, GISLAINE R.. Actinic keratosis - review for clinical practice. INTERNATIONAL JOURNAL OF DERMATOLOGY, v. 58, n. 4, p. 400-407, . (15/02129-6)
POMPEU RAMINELLI, ANA CLAUDIA; ROMERO, VALERIA; SEMREEN, MOHAMMAD H.; LEONARDI, GISLAINE RICCI. Nanotechnological Advances for Cutaneous Release of Tretinoin: An Approach to Minimize Side Effects and Improve Therapeutic Efficacy. Current Medicinal Chemistry, v. 25, n. 31, p. 3703-3718, . (15/02129-6, 13/01118-5)
POMPEU RAMINELLI, ANA CLAUDIA; RODRIGUES-OLIVEIRA, ANDRE FELIPE; YOKOTA, RODRIGO; SUMITA, JULIANA MAYUMI; OLIVEIRA-SILVA, DIOGO; WAMBIER, CARLOS GUSTAVO; BAGATIN, EDILEIA; LEONARDI, GISLAINE RICCI. Cutaneous absorption of tretinoin in 0.05% cream and 5% chemical peel formulas. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, v. 83, n. 5, p. 1483-1485, . (13/01118-5, 15/02129-6)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.