Advanced search
Start date

Supercritical CO2-assisted process for co-encapsulation of nanocapsules containing butyrate and propionate in microparticles

Grant number: 23/15483-9
Support Opportunities:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): March 25, 2024
Effective date (End): March 24, 2025
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Principal Investigator:Marlus Chorilli
Grantee:Suzana Gonçalves Carvalho
Supervisor: Ernesto Reverchon
Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Research place: Università degli Studi di Salerno, Italy  
Associated to the scholarship:22/14075-1 - Multifunctional systems based on polysaccharides for colon-specific release of post-biotics and their potential for application in the treatment and prevention of inflammatory bowel diseases, BP.PD


Postbiotics are substances released or produced by the metabolic activity of microorganisms, which exert a beneficial effect on the host, directly or indirectly, and may include many different constituents, in which short-chain fatty acids (SCFA) stand out. due to their excellent anti-inflammatory and immunomodulatory properties in combating prevalent intestinal diseases, however, SCFAs have some limitations as they are low molecular weight compounds that have limited clinical use due to unfavorable pharmacokinetics, non-selective pharmacological action, low palatability, and unpleasant odor. The development of colon-specific delivery systems based on nano/microsystems, however, may favor the local selective pharmacological action of these active ingredients, improving their therapeutic efficacy. Traditional techniques frequently used to produce nano/microparticles have many limitations, such as control of the average diameter and morphology, high polydispersity index, need for high temperatures for the drying process compromising the integrity of bioactive compounds, low yield, long processing time, high cost, low drug encapsulation efficiency, by-products, organic solvent residues and surfactants, and compromised stability. To get around these problems, supercritical CO2 (SC-CO2) assisted techniques have been explored for drug delivery due to their advantages such as controlled shape, narrow size distribution of the microparticles, high drug encapsulation efficiency, and treatment of thermolabile bioactive compounds. The present project aims to develop multifunctional systems based on nano-in-microparticles using Supercritical assisted electrospray and Continuous Supercritical Emulsions Extraction for the encapsulation of postbiotics, to be carried out at the University of Salerno, under the supervision of Ph.D. Ernesto Reverchon.

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Please report errors in scientific publications list using this form.