Congenital hypothyroidism and thyroid cancer

Autor(es)

Penna, Gustavo ^{[1, 2]} ; Rubio, Ileana G. S. ^{[3, 4, 5]} ; Brust, Ester Saraiva ^{[3, 4]} ; Cazarin, Juliana ^[6] ; Hecht, Fabio ^[6] ; Alkmim, Nina Ramalho ^{[2, 7]} ; Brandao Rajao, Kamilla M. A. ^{[2, 8]} ; Ramos, Helton Estrela ^{[9, 10, 11]}

Afiliação do(s) autor(es):Mostrar menos -

^[1] Univ Fed Minas Gerais, Dept Clin Med, Belo Horizonte, MG - Brazil

^[2] Inst Orizonti, Endocrinol Serv, Belo Horizonte, MG - Brazil

^[3] Univ Fed Sao Paulo, Dept Biol Sci, Mol Thyroid Sci Lab, Sao Paulo - Brazil

^[4] Univ Fed Sao Paulo, Biotechnol Postgrad Program, Sao Paulo - Brazil

^[5] Univ Fed Sao Paulo, Estruct & Funct Biol Program, Sao Paulo - Brazil

^[6] Fed Univ Rio Janeiro, Inst Biophys Carlos Chagas Filho, Lab Endocrine Physiol, Rio De Janeiro - Brazil

^[7] Univ Fed Minas Gerais, Fac Med, Post Grad Program Mol Med, Belo Horizonte, MG - Brazil

^[8] Univ Fed Minas Gerais, Endocrinol Serv Hosp Clin, Belo Horizonte, MG - Brazil

^[9] Univ Fed Bahia, Hlth & Sci Inst, Dept Bioregulat, Thyroid Study Lab, Salvador, BA - Brazil

^[10] Univ Fed Bahia, Hlth & Sci Inst, Postgrad Program Interact Proc Organs & Syst, Salvador, BA - Brazil

^[11] Univ Fed Bahia, Fac Med Sci, Postgrad Program Med & Hlth, Salvador, BA - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Endocrine-Related Cancer; v. 28, n. 9, p. R217-R230, SEP 2021.
• Citações Web of Science: 0

Resumo

Differentiated thyroid carcinoma (DTC) combined with congenital hypothyroidism (CH) is a rare situation, and there is no well-established caus al relationship. CH is a common congenital endocrine, while DTC occurring in childhood represents 0.4-3% of all malignancies at this stage of life. The association of CH w ith DTC could be related to dyshormonogenetic goiter (DHG) or developmental abnormalities. This review will explore the clinical features and the molecular mechanisms potentially associated with the appearance of DTC in CH: sporadic somatic driver mutations, chronic increase of thyroid-stimulating hormone (TSH) levels, higher concentrations of hydrogen peroxide (H2O2), cell division cycle associated 8 (Borelain/CDC8) gene mutations, and in others genes associated with CH - either alone or associated with the mechanisms involved in dyshormonogenesis. There are some pitfalls in the diagnosis of thyroid cancer in patients with CH with nodular goiter, as the proper cytological diagnosis of nodules of patients with dyshormonogenesis might be demanding due to the specific architectural and cytological appearance, which may lead to an erroneous interpretation of malignancy. The purpose of this article is to suggest an analytical framewo rk that embraces the fundamental relationships between the various aspects of CH and CDT. In face of this scenario, the entire genetic and epigenetic context, the complex functioning, and cross talk of cell signaling may determine cellular mechanisms promoting both the maintenance of the differentiated state of the thyroid follicular cell and the disruption of its homeostasis leading to cancer. Whereas, the exact mechanisms for thyroid cancer development in CH remain to be elucidated. (AU)

• Processo FAPESP: 14/24549-4 - Identificação de aletrações genéticas e cromossômicas no exoma completo de pacientes com hipotireoidismo congênito por disgenesia tireoidana
• Beneficiário: Ileana Gabriela Sánchez de Rubió
• Modalidade de apoio: Auxílio à Pesquisa - Regular