Through DNA sensors and hidden mitochondrial effects of SARS-CoV-2

Autor(es)

Targhetta, Vitor Pedro ^[1] ; Amaral, Mariana Abrantes ^[2] ; Saraiva Camara, Niels Olsen ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biomed Sci ICB, Dept Immunol, USP, Sao Paulo, SP - Brazil

^[2] Fed Univ Sao Paulo Unifesp, Paulista Sch Med EPM, Dept Nephrol, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Venomous Animals and Toxins including Tropical Diseases; v. 27, AUG 23 2021.
• Citações Web of Science: 0

Resumo

Abstract The COVID-19 pandemic brought attention to studies about viral infections and their impact on the cell machinery. SARS-CoV-2, for example, invades the host cells by ACE2 interaction and possibly hijacks the mitochondria. To better understand the disease and to propose novel treatments, crucial aspects of SARS-CoV-2 enrolment with host mitochondria must be studied. The replicative process of the virus leads to consequences in mitochondrial function, and cell metabolism. The hijacking of mitochondria, on the other hand, can drive the extrusion of mitochondrial DNA (mtDNA) to the cytosol. Extracellular mtDNA evoke robust proinflammatory responses once detected, that may act in different pathways, eliciting important immune responses. However, few receptors are validated and are able to detect and respond to mtDNA. In this review, we propose that the mtDNA and its detection might be important in the immune process generated by SARS-CoV-2 and that this mechanism might be important in the lung pathogenesis seen in clinical symptoms. Therefore, investigating the mtDNA receptors and their signaling pathways might provide important clues for therapeutic interventions. (AU)

• Processo FAPESP: 17/05264-7 - Metabolismo celular, microbiota e sistema imune: novos paradigmas na fisiopatologia das doenças renais
• Beneficiário: Niels Olsen Saraiva Câmara
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 15/21644-9 - Inflamação induzida pela obesidade, alterações da microbiota e seus efeitos no sistema nervoso entérico: estudo num modelo experimental de zebrafish.
• Beneficiário: Camila Idelí Morales Fénero
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 20/04408-8 - O papel de NLRP1 na resposta antitumoral mediada por linfócitos Th17
• Beneficiário: Vitor Pedro Targhetta
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 21/00946-8 - Efeitos da dieta rica em frutose na produção de espécies reativas de oxigênio em um modelo de Lesão Renal Aguda em Zebrafish
• Beneficiário: Mariana Abrantes do Amaral
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto