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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Through DNA sensors and hidden mitochondrial effects of SARS-CoV-2

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Author(s):
Targhetta, Vitor Pedro [1] ; Amaral, Mariana Abrantes [2] ; Saraiva Camara, Niels Olsen [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci ICB, Dept Immunol, USP, Sao Paulo, SP - Brazil
[2] Fed Univ Sao Paulo Unifesp, Paulista Sch Med EPM, Dept Nephrol, Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Journal of Venomous Animals and Toxins including Tropical Diseases; v. 27, AUG 23 2021.
Web of Science Citations: 0
Abstract

Abstract The COVID-19 pandemic brought attention to studies about viral infections and their impact on the cell machinery. SARS-CoV-2, for example, invades the host cells by ACE2 interaction and possibly hijacks the mitochondria. To better understand the disease and to propose novel treatments, crucial aspects of SARS-CoV-2 enrolment with host mitochondria must be studied. The replicative process of the virus leads to consequences in mitochondrial function, and cell metabolism. The hijacking of mitochondria, on the other hand, can drive the extrusion of mitochondrial DNA (mtDNA) to the cytosol. Extracellular mtDNA evoke robust proinflammatory responses once detected, that may act in different pathways, eliciting important immune responses. However, few receptors are validated and are able to detect and respond to mtDNA. In this review, we propose that the mtDNA and its detection might be important in the immune process generated by SARS-CoV-2 and that this mechanism might be important in the lung pathogenesis seen in clinical symptoms. Therefore, investigating the mtDNA receptors and their signaling pathways might provide important clues for therapeutic interventions. (AU)

FAPESP's process: 17/05264-7 - Cell metabolism, microbiota and immune system: new paradigms in renal diseases physiopathology
Grantee:Niels Olsen Saraiva Câmara
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 15/21644-9 - Obesity-induced inflammation, alterations in the microbiota and their effects on the enteric nervous system: study in an experimental model of zebrafish.
Grantee:Camila Idelí Morales Fénero
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 20/04408-8 - The role of NLRP1 inflamassome in the antitumor response of Th17 limphocytes
Grantee:Vitor Pedro Targhetta
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 21/00946-8 - Effects of fructose rich diet on reactive oxygen species production in Acute Kidney Injury Zebrafish model
Grantee:Mariana Abrantes do Amaral
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)