Heat Shock Proteins: Connectors between Heart and Kidney

Autor(es)

Cruz Junho, Carolina Victoria ^[1] ; Bueno Azevedo, Carolina Amaral ^[2] ; da Cunha, Regiane Stafim ^[2] ; de Yurre, Ainhoa Rodriguez ^[3] ; Medei, Emiliano ^{[3, 4, 5]} ; Marques Stinghen, Andrea Emilia ^[2] ; Carneiro-Ramos, Marcela Sorelli ^[1]

Afiliação do(s) autor(es)

^[1] Fed Univ ABC, Ctr Nat & Human Sci CCNH, Lab Cardiovasc Immunol, BR-09210580 Santo Andre, SP - Brazil

^[2] Univ Fed Parana, Basic Pathol Dept, Expt Nephrol Lab, BR-81531980 Curitiba, Parana - Brazil

^[3] Univ Fed Rio de Janeiro, Inst Biophys Carlos Chagas Filho, Lab Cardioimmunol, BR-21941902 Rio De Janeiro - Brazil

^[4] DOr Inst Res & Educ, BR-21941902 Rio De Janeiro - Brazil

^[5] Univ Fed Rio de Janeiro, Natl Ctr Struct Biol & Bioimaging, BR-22281100 Rio De Janeiro - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: CELLS; v. 10, n. 8 AUG 2021.
• Citações Web of Science: 0

Resumo

Over the development of eukaryotic cells, intrinsic mechanisms have been developed in order to provide the ability to defend against aggressive agents. In this sense, a group of proteins plays a crucial role in controlling the production of several proteins, guaranteeing cell survival. The heat shock proteins (HSPs), are a family of proteins that have been linked to different cellular functions, being activated under conditions of cellular stress, not only imposed by thermal variation but also toxins, radiation, infectious agents, hypoxia, etc. Regarding pathological situations as seen in cardiorenal syndrome (CRS), HSPs have been shown to be important mediators involved in the control of gene transcription and intracellular signaling, in addition to be an important connector with the immune system. CRS is classified as acute or chronic and according to the first organ to suffer the injury, which can be the heart (CRS type 1 and type 2), kidneys (CRS type 3 and 4) or both (CRS type 5). In all types of CRS, the immune system, redox balance, mitochondrial dysfunction, and tissue remodeling have been the subject of numerous studies in the literature in order to elucidate mechanisms and propose new therapeutic strategies. In this sense, HSPs have been targeted by researchers as important connectors between kidney and heart. Thus, the present review has a focus to present the state of the art regarding the role of HSPs in the pathophysiology of cardiac and renal alterations, as well their role in the kidney-heart axis. (AU)

• Processo FAPESP: 08/10175-4 - Impacto da resposta inflamatória sistêmica induzida pela lesão renal aguda no tecido cardíaco
• Beneficiário: Marcela Sorelli Carneiro Ramos
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 18/03089-6 - Papel do eixo Klotho/FGF23 no desenvolvimento da Síndrome Cardiorenal do tipo 3 induzida por lesão renal isquêmica
• Beneficiário: Carolina Victória da Cruz Junho
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 19/11077-0 - Alterações cardíacas induzidas por modelos de inflamação renal: participação do eixo Klotho/FGF-23
• Beneficiário: Marcela Sorelli Carneiro Ramos
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/19107-5 - TLR4 e sistema complemento: possível mecanismo chave na resposta hipertrófica do tecido cardíaco em quadro inflamatório sistêmico induzido por lesão isquêmica renal
• Beneficiário: Marcela Sorelli Carneiro Ramos
• Modalidade de apoio: Auxílio à Pesquisa - Regular