Heat Shock Proteins: Connectors between Heart and Kidney

Author(s)

Cruz Junho, Carolina Victoria ^[1] ; Bueno Azevedo, Carolina Amaral ^[2] ; da Cunha, Regiane Stafim ^[2] ; de Yurre, Ainhoa Rodriguez ^[3] ; Medei, Emiliano ^{[3, 4, 5]} ; Marques Stinghen, Andrea Emilia ^[2] ; Carneiro-Ramos, Marcela Sorelli ^[1]

Affiliation

^[1] Fed Univ ABC, Ctr Nat & Human Sci CCNH, Lab Cardiovasc Immunol, BR-09210580 Santo Andre, SP - Brazil

^[2] Univ Fed Parana, Basic Pathol Dept, Expt Nephrol Lab, BR-81531980 Curitiba, Parana - Brazil

^[3] Univ Fed Rio de Janeiro, Inst Biophys Carlos Chagas Filho, Lab Cardioimmunol, BR-21941902 Rio De Janeiro - Brazil

^[4] DOr Inst Res & Educ, BR-21941902 Rio De Janeiro - Brazil

^[5] Univ Fed Rio de Janeiro, Natl Ctr Struct Biol & Bioimaging, BR-22281100 Rio De Janeiro - Brazil

• Document type: Review article
• Source: CELLS; v. 10, n. 8 AUG 2021.
• Web of Science Citations: 0

Abstract

Over the development of eukaryotic cells, intrinsic mechanisms have been developed in order to provide the ability to defend against aggressive agents. In this sense, a group of proteins plays a crucial role in controlling the production of several proteins, guaranteeing cell survival. The heat shock proteins (HSPs), are a family of proteins that have been linked to different cellular functions, being activated under conditions of cellular stress, not only imposed by thermal variation but also toxins, radiation, infectious agents, hypoxia, etc. Regarding pathological situations as seen in cardiorenal syndrome (CRS), HSPs have been shown to be important mediators involved in the control of gene transcription and intracellular signaling, in addition to be an important connector with the immune system. CRS is classified as acute or chronic and according to the first organ to suffer the injury, which can be the heart (CRS type 1 and type 2), kidneys (CRS type 3 and 4) or both (CRS type 5). In all types of CRS, the immune system, redox balance, mitochondrial dysfunction, and tissue remodeling have been the subject of numerous studies in the literature in order to elucidate mechanisms and propose new therapeutic strategies. In this sense, HSPs have been targeted by researchers as important connectors between kidney and heart. Thus, the present review has a focus to present the state of the art regarding the role of HSPs in the pathophysiology of cardiac and renal alterations, as well their role in the kidney-heart axis. (AU)

• FAPESP's process: 08/10175-4 - Impact of inflammatory response induced by acute renal ischemia in cardiac tissue
• Grantee: Marcela Sorelli Carneiro Ramos
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 18/03089-6 - Role of the Klotho/FGF23 axis in the development of Type 3 Cardiorenal Syndrome induced by ischemic renal injury
• Grantee: Carolina Victória da Cruz Junho
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 19/11077-0 - Cardiac alterations induced by renal inflammation models: participation of the Klotho/FGF-23 axis
• Grantee: Marcela Sorelli Carneiro Ramos
• Support Opportunities: Regular Research Grants
• FAPESP's process: 15/19107-5 - TLR4 and complement system : possible key mechanism in renal ischemia/reperfusion induced cardiac hypertrophy
• Grantee: Marcela Sorelli Carneiro Ramos
• Support Opportunities: Regular Research Grants