Influence of Different Types of Corticosteroids on Heart Rate Variability of Individuals with Duchenne Muscular Dystrophy-A Pilot Cross Sectional Study

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Dias, Rodrigo Martins ^[1] ; Hoshi, Rosangela Akemi ^[2] ; Marques Vanderlei, Luiz Carlos ^[3] ; de Mello Monteiro, Carlos Bandeira ^[4] ; Boscolo Alvarez, Mayra Priscila ^{[4, 5]} ; Crocetta, Tania Brusque ^[6] ; Grossklauss, Luis Fernando ^[7] ; Goncalves Luiz Fernani, Deborah Cristina ^[8] ; Artero Prado Dantas, Maria Tereza ^[8] ; Almeida Martins, Fabiana Paula ^[9] ; Garner, David M. ^[10] ; Abreu, Luiz Carlos ^[11] ; Ferreira, Celso ^[1] ; da Silva, Talita Dias ^{[1, 4, 12]}

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^[1] Fed Univ Sao Paulo EPM UNIFESP, Paulista Sch Med, Postgrad Program Med Cardiol, BR-04024002 Sao Paulo - Brazil

^[2] Brigham & Womens Hosp, Cardiol Dept, Boston, MA 02115 - USA

^[3] FCT UNESP, Fac Sci & Technol, Dept Physiotherapy, BR-19060900 Presidente Prudente - Brazil

^[4] Univ Sao Paulo FMUSP, Fac Med, Postgrad Program Rehabil Sci, BR-05360160 Sao Paulo - Brazil

^[5] Anhanguera Coll, Dept Hlth Sci, Campus Jundiai, BR-13209355 Jundiai - Brazil

^[6] Univ Estado Santa Catarina, Ctr Ciencias Saude & Esporte, Lab Psicol Esporte & Exercicio, BR-88035001 Florianopolis, SC - Brazil

^[7] Univ Fed Sao Paulo, Dept Neurol Neurosurg, BR-04039002 Sao Paulo - Brazil

^[8] Univ Western Paulista UNOESTE, Dept Hlth Sci, BR-19050920 Presidente Prudente - Brazil

^[9] ABC Med Sch FMABC, Study Design & Sci Writing Lab, BR-09060870 Santo Andre, SP - Brazil

^[10] Oxford Brookes Univ, Fac Hlth & Life Sci, Dept Biol & Med Sci, Cardioresp Res Grp, Headington Campus, Gipsy Lane, Oxford OX3 0BP - England

^[11] Fed Univ Espirito Santo UFES, Dept Integrated Hlth Educ, BR-29040090 Vitoria, ES - Brazil

^[12] Univ Sao Paulo City UNICID, Fac Med, BR-03071000 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: LIFE-BASEL; v. 11, n. 8 AUG 2021.
• Citações Web of Science: 0

Resumo

Individuals with Duchenne Muscular Dystrophy (DMD) have an impairment of cardiac autonomic function categorized by parasympathetic reduction and sympathetic predominance. The objective of this study was to assess the cardiac autonomic modulation of individuals with DMD undergoing therapy with Prednisone/Prednisolone and Deflazacort and compare with individuals with DMD without the use of these medications and a typically developed control group. Methods: A cross-sectional study was completed, wherein 40 boys were evaluated. The four treatment groups were: Deflazacort; Prednisone/Prednisolone; no corticoid use; and typical development. Heart Rate Variability (HRV) was investigated via linear indices (Time Domain and Frequency Domain) and non-linear indices Results: The results of this study revealed that individuals with DMD undertaking pharmacotherapies with Prednisolone demonstrated HRV comparable to the Control Typically Developed (CTD) group. In contrast, individuals with DMD undergoing pharmacotherapies with Deflazacort achieved lower HRV, akin to individuals with DMD without any medications, as demonstrated in the metrics: RMSSD; LF (n.u.), HF (n.u.), LF/HF; SD1, alpha 1, and alpha 1/alpha 2, and a significant effect for SD1/SD2; %DET and Ratio; Shannon Entropy, 0 V%, 2 LV% and 2 ULV%. Conclusions: Corticosteroids have the potential to affect the cardiac autonomic modulation in adolescents with DMD. The use of Prednisone/Prednisolone appears to promote improved responses in terms of sympathovagal activity as opposed to Deflazacort. (AU)

• Processo FAPESP: 16/08358-0 - Análise de viabilidade de jogos digitais adaptáveis ao perfil de pessoas com deficiência como instrumento de apoio à reabilitação
• Beneficiário: Talita Dias da Silva Magalhães
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisa Inovativa em Pequenas Empresas - PIPE
• Processo FAPESP: 17/24991-7 - Transferência de desempenho motor entre ambientes virtuais e reais em pessoas com Distrofia Muscular de Duchenne
• Beneficiário: Carlos Bandeira de Mello Monteiro
• Modalidade de apoio: Bolsas no Exterior - Pesquisa
• Processo FAPESP: 11/07277-2 - Aprendizagem motora por meio de realidade aumentada na paralisia cerebral
• Beneficiário: Carlos Bandeira de Mello Monteiro
• Modalidade de apoio: Auxílio à Pesquisa - Regular