RNA-induced inflammation and migration of precursor neurons initiates neuronal circuit regeneration in zebrafish

Autor(es):Mostrar menos -

Vandestadt, Celia ^[1] ; Vanwalleghem, Gilles C. ^[2] ; Khabooshan, Mitra Amiri ^[1] ; Douek, Alon M. ^[1] ; Castillo, Hozana Andrade ^{[1, 3]} ; Li, Mei ^[1] ; Schulze, Keith ^[4] ; Don, Emily ^[5] ; Stamatis, Sebastian-Alexander ^[1] ; Ratnadiwakara, Madara ^[6] ; Anko, Minna-Liisa ^{[6, 7]} ; Scott, Ethan K. ^[2] ; Kaslin, Jan ^[1]

Afiliação do(s) autor(es)

^[1] Monash Univ, Australian Regenerat Med Inst, Clayton, Vic 3800 - Australia

^[2] Univ Queensland, Queensland Brain Inst, St Lucia, Qld - Australia

^[3] Brazilian Ctr Res Energy & Mat, Brazilian Biosci Natl Lab, BR-13083100 Campinas - Brazil

^[4] Monash Univ, Monash Micro Imaging, Clayton, Vic 3800 - Australia

^[5] Macquarie Univ, Dept Biomed Sci, Ctr Motor Neuron Dis Res, Fac Med & Hlth Sci, Macquarie Pk, NSW 2109 - Australia

^[6] Hudson Inst Med Res, Ctr Reprod Hlth & Ctr Canc Res, Clayton, Vic 3168 - Australia

^[7] Monash Univ, Dept Mol & Translat Sci, Clayton, Vic 3800 - Australia

• Tipo de documento: Artigo Científico
• Fonte: DEVELOPMENTAL CELL; v. 56, n. 16, p. 2364+, AUG 23 2021.
• Citações Web of Science: 0

Resumo

Tissue regeneration and functional restoration after injury are considered as stem- and progenitor-cell-driven processes. In the central nervous system, stem cell-driven repair is slow and problematic because function needs to be restored rapidly for vital tasks. In highly regenerative vertebrates, such as zebrafish, functional recovery is rapid, suggesting a capability for fast cell production and functional integration. Surprisingly, we found that migration of dormant ``precursor neurons'' to the injury site pioneers functional circuit regeneration after spinal cord injury and controls the subsequent stem-cell-driven repair response. Thus, the precursor neurons make do before the stem cells make new. Furthermore, RNA released from the dying or damaged cells at the site of injury acts as a signal to attract precursor neurons for repair. Taken together, our data demonstrate an unanticipated role of neuronal migration and RNA as drivers of neural repair. (AU)

• Processo FAPESP: 17/06022-7 - Identificação dos mecanismos celulares e moleculares da regeneração da medula espinhal em peixe-zebra
• Beneficiário: Hozana Andrade Castillo
• Modalidade de apoio: Bolsas no Exterior - Pesquisa