Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

RNA-induced inflammation and migration of precursor neurons initiates neuronal circuit regeneration in zebrafish

Full text
Author(s):
Show less -
Vandestadt, Celia [1] ; Vanwalleghem, Gilles C. [2] ; Khabooshan, Mitra Amiri [1] ; Douek, Alon M. [1] ; Castillo, Hozana Andrade [1, 3] ; Li, Mei [1] ; Schulze, Keith [4] ; Don, Emily [5] ; Stamatis, Sebastian-Alexander [1] ; Ratnadiwakara, Madara [6] ; Anko, Minna-Liisa [6, 7] ; Scott, Ethan K. [2] ; Kaslin, Jan [1]
Total Authors: 13
Affiliation:
[1] Monash Univ, Australian Regenerat Med Inst, Clayton, Vic 3800 - Australia
[2] Univ Queensland, Queensland Brain Inst, St Lucia, Qld - Australia
[3] Brazilian Ctr Res Energy & Mat, Brazilian Biosci Natl Lab, BR-13083100 Campinas - Brazil
[4] Monash Univ, Monash Micro Imaging, Clayton, Vic 3800 - Australia
[5] Macquarie Univ, Dept Biomed Sci, Ctr Motor Neuron Dis Res, Fac Med & Hlth Sci, Macquarie Pk, NSW 2109 - Australia
[6] Hudson Inst Med Res, Ctr Reprod Hlth & Ctr Canc Res, Clayton, Vic 3168 - Australia
[7] Monash Univ, Dept Mol & Translat Sci, Clayton, Vic 3800 - Australia
Total Affiliations: 7
Document type: Journal article
Source: DEVELOPMENTAL CELL; v. 56, n. 16, p. 2364+, AUG 23 2021.
Web of Science Citations: 0
Abstract

Tissue regeneration and functional restoration after injury are considered as stem- and progenitor-cell-driven processes. In the central nervous system, stem cell-driven repair is slow and problematic because function needs to be restored rapidly for vital tasks. In highly regenerative vertebrates, such as zebrafish, functional recovery is rapid, suggesting a capability for fast cell production and functional integration. Surprisingly, we found that migration of dormant ``precursor neurons'' to the injury site pioneers functional circuit regeneration after spinal cord injury and controls the subsequent stem-cell-driven repair response. Thus, the precursor neurons make do before the stem cells make new. Furthermore, RNA released from the dying or damaged cells at the site of injury acts as a signal to attract precursor neurons for repair. Taken together, our data demonstrate an unanticipated role of neuronal migration and RNA as drivers of neural repair. (AU)

FAPESP's process: 17/06022-7 - Identification of the cellular and molecular mechanisms of zebrafish spinal cord regeneration
Grantee:Hozana Andrade Castillo
Support Opportunities: Scholarships abroad - Research