Potential Use of DMSA-Containing Iron Oxide Nanoparticles as Magnetic Vehicles against the COVID-19 Disease

Autor(es)

Martins, Elisama S. ^[1] ; Espindola, Ariane ^{[1, 2]} ; Britos, Tatiane N. ^[1] ; Chagas, Camila ^[3] ; Barbosa, Emerson ^[3] ; Castro, Carlos E. ^[4] ; Fonseca, Fernando L. A. ^{[1, 3]} ; Haddad, Paula S. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Chem, Rua Sao Nicolau 210, BR-09961400 Diadema, SP - Brazil

^[2] Univ Haute Alsace, Inst Sci Mat Mulhouse IS2 M, 15 Rue Jean Starcky, F-68057 Mulhouse - France

^[3] Fac Med ABC FMABC, Ave Principe Gales 667, BR-09060590 Santo Andre, SP - Brazil

^[4] Fed Univ ABC UFABC, Ctr Nat & Human Sci, Av Estados 5001, BR-09210580 Santo Andre, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CHEMISTRYSELECT; v. 6, n. 31, p. 7931-7935, AUG 20 2021.
• Citações Web of Science: 0

Resumo

Iron oxide magnetic nanoparticles have been employed as potential vehicles for a large number of biomedical applications, such as drug delivery. This article describes the synthesis, characterization and in vitro cytotoxic in COVID-19 cells evaluation of DMSA superparamagnetic iron oxide magnetic nanoparticles. Magnetite (Fe3O4) nanoparticles were synthesized by co-precipitation of iron salts and coated with meso-2,3-dimercaptosuccinic acid (DMSA) molecule. Structural and morphological characterizations were performed by X-ray diffraction (XRD), Fourier transformed infrared (FT-IR), magnetic measurements (SQUID), transmission electron microscopy (TEM), and dynamic light scattering (DLS). Our results demonstrate that the nanoparticles have a mean diameter of 12 nm in the solid-state and are superparamagnetic at room temperature. There is no toxicity of SPIONS-DMSA under the cells of patients with COVID-19. Taken together the results show that DMSA- Fe3O4 are good candidates as nanocarriers in the alternative treatment of studied cells. (AU)

• Processo FAPESP: 18/12219-0 - Avaliação da toxicidade e ação antineoplásica em camundongos tipo BALB/c inoculados com Tumor de Ehrlich tratados com nanopartículas superparamagnéticas
• Beneficiário: Camila dos Santos Chagas
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 17/15061-6 - Preparação, Caracterização e Ensaios Biológicos de Materiais Nanoestruturados Baseados em Nanopartículas Superparamagnéticas Metálicas e Bimetálicas
• Beneficiário: Paula Silvia Haddad Ferreira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 19/07454-3 - Preparação e investigação estrutural e magnética de nanopartículas metálicas e bimetálicas de Fe como potenciais veículos carreadores de fármacos
• Beneficiário: Elisama Silva Martins
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica