Potential Use of DMSA-Containing Iron Oxide Nanoparticles as Magnetic Vehicles against the COVID-19 Disease

Author(s)

Martins, Elisama S. ^[1] ; Espindola, Ariane ^{[1, 2]} ; Britos, Tatiane N. ^[1] ; Chagas, Camila ^[3] ; Barbosa, Emerson ^[3] ; Castro, Carlos E. ^[4] ; Fonseca, Fernando L. A. ^{[1, 3]} ; Haddad, Paula S. ^[1]

Affiliation

^[1] Univ Fed Sao Paulo, Dept Chem, Rua Sao Nicolau 210, BR-09961400 Diadema, SP - Brazil

^[2] Univ Haute Alsace, Inst Sci Mat Mulhouse IS2 M, 15 Rue Jean Starcky, F-68057 Mulhouse - France

^[3] Fac Med ABC FMABC, Ave Principe Gales 667, BR-09060590 Santo Andre, SP - Brazil

^[4] Fed Univ ABC UFABC, Ctr Nat & Human Sci, Av Estados 5001, BR-09210580 Santo Andre, SP - Brazil

• Document type: Journal article
• Source: CHEMISTRYSELECT; v. 6, n. 31, p. 7931-7935, AUG 20 2021.
• Web of Science Citations: 0

Abstract

Iron oxide magnetic nanoparticles have been employed as potential vehicles for a large number of biomedical applications, such as drug delivery. This article describes the synthesis, characterization and in vitro cytotoxic in COVID-19 cells evaluation of DMSA superparamagnetic iron oxide magnetic nanoparticles. Magnetite (Fe3O4) nanoparticles were synthesized by co-precipitation of iron salts and coated with meso-2,3-dimercaptosuccinic acid (DMSA) molecule. Structural and morphological characterizations were performed by X-ray diffraction (XRD), Fourier transformed infrared (FT-IR), magnetic measurements (SQUID), transmission electron microscopy (TEM), and dynamic light scattering (DLS). Our results demonstrate that the nanoparticles have a mean diameter of 12 nm in the solid-state and are superparamagnetic at room temperature. There is no toxicity of SPIONS-DMSA under the cells of patients with COVID-19. Taken together the results show that DMSA- Fe3O4 are good candidates as nanocarriers in the alternative treatment of studied cells. (AU)

• FAPESP's process: 18/12219-0 - Evaluation of toxicity and antineoplastic action in BALB/c mice inoculated with Ehrlich's Tumor treated with superparamagnetic nanoparticles
• Grantee: Camila dos Santos Chagas
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 17/15061-6 - Preparation, Characterization and Biological Essay of Nanostructured Materials Based on Superparamagnetic Metallic and Bimetallic Nanoparticles
• Grantee: Paula Silvia Haddad Ferreira
• Support Opportunities: Regular Research Grants
• FAPESP's process: 19/07454-3 - Preparation and structural and magnetic investigation of metal and bimetallic Fe nanoparticles as potential drug carrier vehicles
• Grantee: Elisama Silva Martins
• Support Opportunities: Scholarships in Brazil - Scientific Initiation