| Full text | |
| Author(s): |
Martins, Elisama S.
[1]
;
Espindola, Ariane
[1, 2]
;
Britos, Tatiane N.
[1]
;
Chagas, Camila
[3]
;
Barbosa, Emerson
[3]
;
Castro, Carlos E.
[4]
;
Fonseca, Fernando L. A.
[1, 3]
;
Haddad, Paula S.
[1]
Total Authors: 8
|
| Affiliation: | [1] Univ Fed Sao Paulo, Dept Chem, Rua Sao Nicolau 210, BR-09961400 Diadema, SP - Brazil
[2] Univ Haute Alsace, Inst Sci Mat Mulhouse IS2 M, 15 Rue Jean Starcky, F-68057 Mulhouse - France
[3] Fac Med ABC FMABC, Ave Principe Gales 667, BR-09060590 Santo Andre, SP - Brazil
[4] Fed Univ ABC UFABC, Ctr Nat & Human Sci, Av Estados 5001, BR-09210580 Santo Andre, SP - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | CHEMISTRYSELECT; v. 6, n. 31, p. 7931-7935, AUG 20 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Iron oxide magnetic nanoparticles have been employed as potential vehicles for a large number of biomedical applications, such as drug delivery. This article describes the synthesis, characterization and in vitro cytotoxic in COVID-19 cells evaluation of DMSA superparamagnetic iron oxide magnetic nanoparticles. Magnetite (Fe3O4) nanoparticles were synthesized by co-precipitation of iron salts and coated with meso-2,3-dimercaptosuccinic acid (DMSA) molecule. Structural and morphological characterizations were performed by X-ray diffraction (XRD), Fourier transformed infrared (FT-IR), magnetic measurements (SQUID), transmission electron microscopy (TEM), and dynamic light scattering (DLS). Our results demonstrate that the nanoparticles have a mean diameter of 12 nm in the solid-state and are superparamagnetic at room temperature. There is no toxicity of SPIONS-DMSA under the cells of patients with COVID-19. Taken together the results show that DMSA- Fe3O4 are good candidates as nanocarriers in the alternative treatment of studied cells. (AU) | |
| FAPESP's process: | 18/12219-0 - Evaluation of toxicity and antineoplastic action in BALB/c mice inoculated with Ehrlich's Tumor treated with superparamagnetic nanoparticles |
| Grantee: | Camila dos Santos Chagas |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 17/15061-6 - Preparation, Characterization and Biological Essay of Nanostructured Materials Based on Superparamagnetic Metallic and Bimetallic Nanoparticles |
| Grantee: | Paula Silvia Haddad Ferreira |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 19/07454-3 - Preparation and Structural and Magnetic Investigation of Metal and Bimetallic Fe Nanoparticles as Potential Drug Carrier Vehicles |
| Grantee: | Elisama Silva Martins |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |