ffect of bioactive glasses containing strontium and potassium on dentin permeabilit

Autor(es)

Acevedo, Luisa Alegria ^[1] ; Campos, Leticia Antonelo ^[1] ; Dechandt, Iolanda Cristina ^[2] ; Alegria, Gustavo ^[3] ; Siqueira, Renato Luiz ^[4] ; Zanotto, Edgar Dutra ^[4] ; Serbena, Francisco Carlos ^[2] ; Santos, Fabio Andre ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Ponta Grossa, Sch Dent, State Univ Ponta Grossa, Ponta Grossa, PR - Brazil

^[2] Univ Estadual Ponta Grossa, Sch Phys, State Univ Ponta Grossa, Ponta Grossa, PR - Brazil

^[3] Univ Valle, Dept Dent, Santiago De Cali, Valle Del Cauca - Colombia

^[4] Univ Fed Sao Carlos, Dept Mat Engn, UFSCar, Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS; v. 110, n. 3 SEP 2021.
• Citações Web of Science: 0

Resumo

Dentin hypersensitivity (DH) is characterized by pain caused by an external stimulus on exposed dentin. Different therapeutic approaches have been proposed to mitigate this problem; however, none of them provide permanent pain relief. In this study, we synthesized and characterized experimental bioactive glasses containing 3.07 mol% SrO or 3.36 mol% K2O (both equivalent to 5 wt% in the glass), and evaluated their effect on dentin permeability to verify their potential to treat DH. The experimental materials were characterized by field-emission scanning electron microscopy, Fourier transform infrared spectroscopy, micro-Raman spectroscopy, and X-ray diffraction to confirm the respective structures and chemical compositions. The reduction in the hydraulic conductance of dentin was evaluated at the three stages: minimum permeability; maximum permeability (24% ethylenediaminetetraacetic acid {[}EDTA] treatment); and final dentin permeability after treatment with the bioactive glasses. They all promoted a reduction in dentin permeability, with a significant difference for each sample and posttreatment group. Also, a significant reduction in dentin permeability was observed even after a simulated toothbrushing test, demonstrating effective action of these materials against DH. Besides, incorporating 3.07 mol% SrO was a positive factor. Therefore, strontium's desensitizing and re-mineralizing properties can be further exploited in bioactive glasses to promote a synergistic effect to treat DH. (AU)

• Processo FAPESP: 13/07793-6 - CEPIV - Centro de Ensino, Pesquisa e Inovação em Vidros
• Beneficiário: Edgar Dutra Zanotto
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs