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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

ffect of bioactive glasses containing strontium and potassium on dentin permeabilit

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Author(s):
Acevedo, Luisa Alegria [1] ; Campos, Leticia Antonelo [1] ; Dechandt, Iolanda Cristina [2] ; Alegria, Gustavo [3] ; Siqueira, Renato Luiz [4] ; Zanotto, Edgar Dutra [4] ; Serbena, Francisco Carlos [2] ; Santos, Fabio Andre [1]
Total Authors: 8
Affiliation:
[1] Univ Estadual Ponta Grossa, Sch Dent, State Univ Ponta Grossa, Ponta Grossa, PR - Brazil
[2] Univ Estadual Ponta Grossa, Sch Phys, State Univ Ponta Grossa, Ponta Grossa, PR - Brazil
[3] Univ Valle, Dept Dent, Santiago De Cali, Valle Del Cauca - Colombia
[4] Univ Fed Sao Carlos, Dept Mat Engn, UFSCar, Sao Carlos, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS; v. 110, n. 3 SEP 2021.
Web of Science Citations: 0
Abstract

Dentin hypersensitivity (DH) is characterized by pain caused by an external stimulus on exposed dentin. Different therapeutic approaches have been proposed to mitigate this problem; however, none of them provide permanent pain relief. In this study, we synthesized and characterized experimental bioactive glasses containing 3.07 mol% SrO or 3.36 mol% K2O (both equivalent to 5 wt% in the glass), and evaluated their effect on dentin permeability to verify their potential to treat DH. The experimental materials were characterized by field-emission scanning electron microscopy, Fourier transform infrared spectroscopy, micro-Raman spectroscopy, and X-ray diffraction to confirm the respective structures and chemical compositions. The reduction in the hydraulic conductance of dentin was evaluated at the three stages: minimum permeability; maximum permeability (24% ethylenediaminetetraacetic acid {[}EDTA] treatment); and final dentin permeability after treatment with the bioactive glasses. They all promoted a reduction in dentin permeability, with a significant difference for each sample and posttreatment group. Also, a significant reduction in dentin permeability was observed even after a simulated toothbrushing test, demonstrating effective action of these materials against DH. Besides, incorporating 3.07 mol% SrO was a positive factor. Therefore, strontium's desensitizing and re-mineralizing properties can be further exploited in bioactive glasses to promote a synergistic effect to treat DH. (AU)

FAPESP's process: 13/07793-6 - CEPIV - Center for Teaching, Research and Innovation in Glass
Grantee:Edgar Dutra Zanotto
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC