| Texto completo | |
| Autor(es): |
Tanamachi, Amanda Rodrigues
[1, 2]
;
Fernandes, Fabio Henrique
[1, 2]
;
de Souza Vendemiatti, Josiane Aparecida
[3]
;
Prediger, Patricia
[3]
;
Camparotto, Natalia Gabriele
[3]
;
Rocha, Noeme Sousa
[4]
;
Umbuzeiro, Gisela Aragao
[3]
;
Favero Salvadori, Daisy Maria
[1, 2]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Sao Paulo State Univ Unesp, Med Sch, Dept Pathol, Botucatu, SP - Brazil
[2] Natl Inst Alternat Technol Detect Toxicol Evaluat, Inst Chem, Araraquara, SP - Brazil
[3] State Univ Campinas UNICAMP, Sch Technol, Limeira, SP - Brazil
[4] Sao Paulo State Univ UNESP, Sch Vet & Zootech, Botucatu, SP - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Environmental and Molecular Mutagenesis; v. 62, n. 8 SEP 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
Dinitrophenylazo dyes can form 2-phenylbenzotriazoles (PBTAs) in the textile dyeing process upon the addition of chemical reducing agents. Some dinitrophenylazo dyes, as well as their respective reduced (non-chlorinated) and chlorinated PBTAs, are now found in rivers owing to wastewater from textile plants. This study aimed to investigate the genotoxicity of a new PBTA derived from C.I. Disperse Violet 93 azo dye, namely non-Cl PBTA-9. Primary DNA damage in the blood, liver, and colon cells, micronucleated cells in the bone marrow, and gene expression (NAT2, CYP1A1, TRP53, and CDKN1A) in liver cells were observed in mice, at acute oral exposure (gavage) doses of 5, 50, and 500 mu g/kg body weight (b.w.). The non-chlorinated PBTA-9 caused DNA damage in the blood and liver (at 500 mu g/kg b.w.) and in colon cells (at 5, 50, and 500 mu g/kg), and increased the frequency of micronucleated cells in the bone marrow (at 5 and 50 mu g/kg). No histological alterations or gene expression changes were observed. In conclusion, in vivo exposure to non-chlorinated PBTA-9 induced genetic damage in various rodent tissues, corroborating results previously obtained from the Ames test. Because this compound has been detected in rivers, exposure to humans and biota is a major concern. (AU) | |
| Processo FAPESP: | 18/04105-5 - Potencial toxicogenômico do contaminante ambiental 2-fenilbenzotriazol 9 (PBTA-9) in vivo |
| Beneficiário: | Amanda Rodrigues Tanamachi |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 19/07822-2 - Síntese de novos nanoadsorventes, suas caracterizações e aplicações na adsorção de poluentes em águas |
| Beneficiário: | Patricia Prediger |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 14/50945-4 - INCT 2014: Instituto Nacional de Tecnologias Alternativas para Detecção, Avaliação Toxicológica e Remoção de Micropoluentes e Radioativos |
| Beneficiário: | Maria Valnice Boldrin |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |