COVID-19 induces proatherogenic alterations in moderate to severe non-comorbid patients: A single-center observational study

Autor(es)

Kimura, Louise F. ^[1] ; Sant'Anna, Morena B. ^[1] ; Andrade, Sonia A. ^[1] ; Ebram, Matteo C. ^[1] ; Lima, Cristiane F. G. ^[1] ; Celano, Rosa M. G. ^[2] ; Viegas, Ruy F. M. ^[2] ; Picolo, Gisele ^[1]

Afiliação do(s) autor(es)

^[1] Butantan Inst, Lab Pain & Signaling, Ave Vital Brazil 1500, BR-05503900 Sao Paulo, SP - Brazil

^[2] Univ Taubate UNITAU, Rua Quatro Marco 432, BR-12020270 Taubate, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BLOOD CELLS MOLECULES AND DISEASES; v. 92, DEC 2021.
• Citações Web of Science: 0

Resumo

Patients with COVID-19 can be asymptomatic or present mild to severe symptoms, leading to respiratory and cardiovascular complications and death. Type 2 diabetes mellitus (T2DM) and obesity are considered risk factors for COVID-19 poor prognosis. In parallel, COVID-19 severe patients exhibit dyslipidemia and alterations in neutrophil to lymphocyte ratio (NLR) associated with disease severity and mortality. To investigate whether such alterations are caused by the infection or results from preexisting comorbidities, this work analyzed dyslipidemia and the hemogram profile of COVID-19 patients according to the severity and compared with patients without T2DM or obesity comorbidities. Dyslipidemia, with a marked decrease in HDL levels, and increased NLR accompanied the disease severity, even in non-T2DM and non-obese patients, indicating that COVID-19 causes the observed alterations. Because decreased hemoglobin is involved in COVID-19 severity, and hemoglobin concentration is associated with metabolic diseases, the erythrogram of patients was also evaluated. We verified a drop in hemoglobin and erythrocyte number in severe patients, independently of T2DM and obesity, which may explain in part the need for artificial ventilation in severe cases. Thus, the control of such parameters (especially HDL levels, NLR, and hemoglobin concentration) could be a good strategy to prevent COVID-19 complications and death. (AU)

• Processo FAPESP: 19/05882-8 - Avaliação do papel da crotalfina na dinâmica do cílio primário de neurônios aferentes primários: novos caminhos para o estudo de compostos analgésicos
• Beneficiário: Louise Faggionato Kimura Vieira
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/07467-1 - CeTICS - Centro de Toxinas, Imuno-Resposta e Sinalização Celular
• Beneficiário: Hugo Aguirre Armelin
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs