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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

COVID-19 induces proatherogenic alterations in moderate to severe non-comorbid patients: A single-center observational study

Full text
Author(s):
Kimura, Louise F. [1] ; Sant'Anna, Morena B. [1] ; Andrade, Sonia A. [1] ; Ebram, Matteo C. [1] ; Lima, Cristiane F. G. [1] ; Celano, Rosa M. G. [2] ; Viegas, Ruy F. M. [2] ; Picolo, Gisele [1]
Total Authors: 8
Affiliation:
[1] Butantan Inst, Lab Pain & Signaling, Ave Vital Brazil 1500, BR-05503900 Sao Paulo, SP - Brazil
[2] Univ Taubate UNITAU, Rua Quatro Marco 432, BR-12020270 Taubate, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: BLOOD CELLS MOLECULES AND DISEASES; v. 92, DEC 2021.
Web of Science Citations: 0
Abstract

Patients with COVID-19 can be asymptomatic or present mild to severe symptoms, leading to respiratory and cardiovascular complications and death. Type 2 diabetes mellitus (T2DM) and obesity are considered risk factors for COVID-19 poor prognosis. In parallel, COVID-19 severe patients exhibit dyslipidemia and alterations in neutrophil to lymphocyte ratio (NLR) associated with disease severity and mortality. To investigate whether such alterations are caused by the infection or results from preexisting comorbidities, this work analyzed dyslipidemia and the hemogram profile of COVID-19 patients according to the severity and compared with patients without T2DM or obesity comorbidities. Dyslipidemia, with a marked decrease in HDL levels, and increased NLR accompanied the disease severity, even in non-T2DM and non-obese patients, indicating that COVID-19 causes the observed alterations. Because decreased hemoglobin is involved in COVID-19 severity, and hemoglobin concentration is associated with metabolic diseases, the erythrogram of patients was also evaluated. We verified a drop in hemoglobin and erythrocyte number in severe patients, independently of T2DM and obesity, which may explain in part the need for artificial ventilation in severe cases. Thus, the control of such parameters (especially HDL levels, NLR, and hemoglobin concentration) could be a good strategy to prevent COVID-19 complications and death. (AU)

FAPESP's process: 19/05882-8 - The role of crotalphine in the primary cilium dynamics of primary afferent neurons: novel insights for the study of analgesic compounds
Grantee:Louise Faggionato Kimura Vieira
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 13/07467-1 - CeTICS - Center of Toxins, Immune-Response and Cell Signaling
Grantee:Hugo Aguirre Armelin
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC