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CeTICS - Center of Toxins, Immune-Response and Cell Signaling

Grant number: 13/07467-1
Support type:Research Grants - Research, Innovation and Dissemination Centers - RIDC
Duration: July 01, 2013 - June 30, 2024
Field of knowledge:Biological Sciences - Biochemistry - Molecular Biology
Principal Investigator:Hugo Aguirre Armelin
Grantee:Hugo Aguirre Armelin
Home Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Co-Principal Investigators:Ana Marisa Chudzinski-Tavassi ; Denise Vilarinho Tambourgi ; Gisele Picolo ; Inácio de Loiola Meirelles Junqueira de Azevedo ; Junior Barrera ; Maria Carolina Quartim Barbosa Elias Sabbaga ; Monica Valdyrce dos Anjos Lopes Ferreira ; Osvaldo Augusto Brazil Esteves Sant'Anna ; Solange Maria de Toledo Serrano ; Wilmar Dias da Silva ; Yara Cury
Assoc. researchers:Adriana Mortara Almeida ; Alessandra Fernandes Bizerra ; Alexandre Keiji Tashima ; Aline Soriano Lopes ; Allan Mowat ; Ana Maria Moura da Silva ; Ana Marisa Chudzinski-Tavassi ; André Zelanis Palitot Pereira ; Ann Ager ; B. PAUL MORGAN ; Carla Cristina Squaiella ; Carla Lima da Silva ; CARMEN W. VAN DEN BERG ; DARIA MOCHLY-ROSEN ; Denise Vilarinho Tambourgi ; Fabio Carlos Magnoli ; Fábio Nakano ; Fan Hui Wen ; Fernanda Calheta Vieira Portaro ; Fernanda Faria ; Fernanda Paiva Guimarães ; Gisele Picolo ; Giselle Pidde Marques Porto ; Inácio de Loiola Meirelles Junqueira de Azevedo ; JAY W. FOX ; Jesus Aparecido Ferro ; Jose Roberto Marcelino ; Jose Salvatore Leister Patane ; Julia Pinheiro Chagas da Cunha ; Katsuhiro Konno ; Kerly Fernanda Mesquita Pasqualoto ; Leo Kei Iwai ; Luc Pellerin ; Luiz Vicente Rizzo ; Marcella Barbosa Faria de Almeida Prado ; Marcelo da Silva Reis ; Marcelo de Franco ; Marcia Carvalho de Abreu Fantini ; Marcio Henrique Zaim ; Maria Carolina Quartim Barbosa Elias Sabbaga ; Maria Teresa Machini ; Marinilce Fagundes dos Santos ; Martha Marandino ; Miguel Allende ; Milton Yutaka Nishiyama Junior ; Mirta Schattner ; Miryam Paola Alvarez Flores ; Ovidiu Radulescu ; Paulo Lee Ho ; Paulo Sérgio Lacerda Beirão ; Pedro Ismael da Silva Junior ; Ricardo Jose Giordano ; Richard Mcculloch ; Robson Lopes de Melo ; Roger Chammas ; Ruy Gastaldoni Jaeger ; Sandra Coccuzzo Sampaio Vessoni ; Silvio Roberto de Azevedo Salinas ; Simone Guedes Calderano ; Sonia Aparecida de Andrade Chudzinski ; Tânia Tomé Martins de Castro ; Vanessa Olzon Zambelli ; Vanessa Rioli
Associated grant(s):19/07809-6 - ICOM ceca conference 2019: roles of museum education: supporting self ánd society, AR.EXT
18/26586-5 - 24th World Congress of dermatology of “The international League of dermatology societies, AR.EXT
17/18281-7 - Multi-user equipment approved in grant 2013/07467-1 - system of NanoLC EASY-nLCTM 1000 - thermo scientific, AP.EMU
+ associated grants 15/10413-6 - ICOM ceca Annual Conference 2015: museum education ánd accessibility: bridging “The gaps, AR.EXT
15/07553-0 - Multi-User Equipment approved in grant 2013/07467-1 : Biacore T200 Surface Plasmon Resonance System, AP.EMU
15/10037-4 - Multi-User Equipment approved in grant 2013/07467-1: flow cytometer, AP.EMU - associated grants
Associated scholarship(s):19/27348-3 - Complement system inhibition as means for controlling inflammation associated to envenomations, BP.PD
20/03718-3 - Understanding the local reactions induced by Loxosceles venoms and their main toxins, BP.PD
20/00770-4 - Synthesis of benznidazole and graphene oxide derivatives and evaluation of their anti-chagasic activities, BP.PD
+ associated scholarships 19/27677-7 - Study of the induction of regulatory microRNAs by TNP dependent on Aryl hydrocarbon Receptor (AhR) activation, BP.PD
19/20025-4 - An approximate Bayesian computation-based approach to tackle the lack of isolation problem in signaling pathway modeling, BE.PQ
19/18565-0 - Evaluation by quantitative in situ hybridization of the transcript levels of Natterin-like in CRISPR/Cas-9 depleted zebrafish, BP.IC
19/10500-7 - EVALUATION OF INFLAMMASOME REQUIREMENT IN NEUTROPHILIC INFLAMMATION INDUCED BY PORE-FORMING TOXINS, NATTERINS, BE.PQ
19/05882-8 - The role of crotalphine in the primary cilium dynamics of primary afferent neurons: novel insights for the study of analgesic compounds, BP.PD
19/13039-9 - Cell cycle control ín normal ánd malignant cells, new approach ín cancer therapy, BP.PD
19/01895-8 - Function of the MRE11, DNA2 and EXO1 nucleases in DNA end resection and double-strand breaks repair in Trypanosoma brucei, BP.PD
19/02333-3 - Validation of the functional importance of natterins in the innate immune response in zebrafish by CRISPR-Cas9, a loss-of-function method, BP.MS
18/06751-1 - Molecular characterization of the in vivo effects of the hemorrhagic metalloproteinase HF3: analyses of the proteome of mice muscle tissue, BP.MS
18/12364-0 - Expression, purification and initial characterization of a new RPA-like protein in Trypanosoma brucei, BP.IC
17/07693-2 - Functional dynamics of Orc1b protein during the life cycle of Trypanosoma, BP.DR
18/08167-5 - Bioinformatic support for differential gene expression projects of CeTICS, BP.TT
18/06682-0 - Computational phylogenetic analysis of Bothrops snakes from venom proteomes, BP.IC
17/06496-9 - Proteomic characterization of the effect of Bothrops jararaca snake venom on normal vs cancer cell lines, BP.MS
17/18344-9 - Quantitative chromatin proteomics upon FGF2 treatment: analysis of transcriptional regulation and involvement of cdc42, BP.DD
17/20575-9 - Identification of cell signaling pathways based on biochemical reaction kinetics repositories, BP.MS
17/19252-0 - Proteomic analysis of the effects of PA-BJ, a serine proteinase of Bothrops jararaca venom, upon peripheral blood endothelial cell culture, BP.PD
17/19545-8 - Analysis of molecular mechanisms underlying FGF2 cell cycle inhibition in mouse Y1 adrenocortical and tumor cells dependent of amplified WT-Kras, BP.PD
17/09929-3 - Bothrops snake venoms: impact of glycosylation on the complexity of proteomes and toxins function, BP.DD
17/12199-7 - Loxoscelism: from basic research to the proposal of new therapies, BP.TT
17/09648-4 - Recombinant expression, and functional characterization of the non-catalytic domains of a P-III class metalloproteinase from Bothrops jararaca snake venom, using a cell-free expression system, BP.IC
16/25959-7 - Design of poset forest-based algorithms for the U-curve optimization problem, BP.IC
16/22774-6 - Epigenetic control in opioid receptor-dependent analgesia: role of miRNA and DNA methylation on the crotalphine antinociceptive effect , BP.PD
17/00715-0 - Proteolytic enzymes from snake venoms trigger cascades of yet unknown molecular events, BP.PD
16/17775-3 - Design and simulation of computational models of the DNA replication dynamics in kinetoplastids, BP.IC
16/16935-7 - A post-translational modification perspective of Bothrops venom toxins: site-specific proteomic Characterization of N-glycans ánd Cys residues, BP.DR
15/12224-6 - Evaluation the mechanisms involved in the survival of long-lived antibody-secreting cells induced by IL-17- released from neutrophil extracellular traps, BE.PQ
16/10613-8 - Analysis of complement system action on micro RNAs expression in systemic loxoscelism, BP.PD
16/07802-3 - Antivenom design based on amino acid sequence of complementarity determining regions (CDRs), BP.PD
15/23691-4 - Pro-inflammatory activity of snake venom proteinases: i)expression of recombinant proteinases in a cell-free system; ii) generation of microvesicles by monocytes stimulated with native and recomb proteinases, and analysis of their interaction with end cells, BP.PD
15/17053-5 - Study of inflamassomes activation, in human keratinocytes, by Loxosceles laeta spider venom and its sphingomyelinase D, BP.PD
15/03509-7 - Genomic sequencing of Brazilian snakes focused on the study of toxins, BP.PD
15/17494-1 - Loxoscelism: from basic research tò “The proposal of new therapies, BP.PD
15/01234-0 - Proteolytic enzymes from snake venoms trigger cascades of yet unknown molecular events, BP.PD
15/04641-6 - Investigation of “The role of desensitization ón Natterin antagonism, BP.IC
14/24170-5 - DNA replication dynamics in Trypanosoma cruzi: licensing and replication rate characterization, BP.PD
15/03953-4 - Integrin expression modulation in neutrophils by Natterins, BP.IC
14/02978-0 - Functional analysis of RPA complex in Trypanosoma cruzi and its involvement with telomeric DNA, BP.DR
14/23564-0 - Studies of efficient data structures to tackle the U-curve optimization problem, BP.IC
14/21557-6 - Functional analysis of ataxia-telangiectasia mutated (ATM) ánd ataxia-telangiectasia ánd RAD3-related (ATR) ín DNA damage response ín Trypanosoma Cruzi, BP.IC
14/18875-6 - Pain and analgesia: molecular mechanisms of new therapeutic drugs and targets, BP.PD
14/13375-5 - Replication origins in trypanosomes, BP.PD
14/01534-1 - Characterization of the inhibition potential of collagen receptor Discoiding domain receptor 2 by snake venom metalloproteases components, BE.PQ
13/24212-7 - Bioinformatics and modelling, BP.PD
13/50694-9 - Evaluation of NET role released by neutrophils in differentiation of long-lived antibody-producing cells in chronic response induced by Thalassophryne nattereri venom, BP.PD
13/07974-0 - Sequencing of Bothrops jararaca genome to characterize toxin gene structure and their regulatory elements, BP.DR
12/51135-0 - Natterins induction verification of TLR signaling pathway regulatory mechanisms, BP.PD
12/20186-9 - Molecular mechanisms of functional interaction between Ras and cyclin D1 in Ras-driven malignant cells, BP.PD
11/09333-7 - Crotalphine: fluorescent analogues and study of mechanism of action in cultures and co-cultures of neurons and keratinocytes, BP.PD - associated scholarships

Abstract

Toxinology and regulation of the lmmune-response are two interconnected classical areas of scientific investigation around which the Butantan Institute historically built its strong international reputation. Indeed, it is deeply rooted in the culture of Butantan lnstitute, the notion that toxins are components in complex venoms, which were selected by evolution to exert concerted systemic biological effects through highly specific biochemical, molecular and cellular mechanisms. As a corollary to this notion, isolation and chemical characterization of venom components very likely can yield novel toxin molecules with high therapeutic potential. Following this historical tradition, in the last 10 years, investigators of the Center for Applied Toxinology (CAT CEPID project) successfully isolated, chemically characterized and patented several novel protein and peptide toxins, which became starting points for development of pharmaceutical innovations in partnership with local industries. This emphasis on proteins and peptides led to deployment of state of the art laboratories for proteomics, transcriptomics, molecular biology of recombinant DNA and peptide synthesis. More recently, studies of biochemical, molecular and cellular mechanisms of hopeful therapeutic drugs were initiated, aiming to establish proofs of concept. Thus, the CAT project has progressively paved the way towards a systems biology oriented center of toxins, immune-response and cell signaling at Butantan lnstitute. The present proposal aims to establish the new Center of Toxins, lmmune-response and Cell Signaling – CeTICS - as a world class center of excellence, taking advantage of the Butantan lnstitute historical international reputation and, also, the research successes and infrastructure legacy of the CAT CEPID project. To this end 10 investigators, representative of the most competitive leaders of research in the Butantan lnstitute, designed a Center's ambitious research plan focused on integration of subprojects biased towards scientific research and subprojects motivated for technological innovations. A large group of senior scientists from Butantan lnstitute, from other Brazilian institutions and, also, from well-known foreign institutions will be collaborators of the Center. (AU)

Matéria(s) publicada(s) na Agência FAPESP sobre o auxílio:
Brazil to begin clinical trials for an oral vaccine against hepatitis B 

Scientific publications (146)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
KIMURA, LOUISE FAGGIONATO; SANT'ANNA, MORENA BRAZIL; ZAMBELLI, VANESSA OLZON; GIARDINI, ALINE CAROLINA; SILVA JARED, SIMONE GONCALVES; ANTONIAZZI, MARTA MARIA; DE MOURA MATTARAIA, VANIA GOMES; PAGANO, ROSANA LIMA; PICOLO, GISELE. Early exposure to environmental enrichment protects male rats against neuropathic pain development after nerve injury. Experimental Neurology, v. 332, OCT 2020. Web of Science Citations: 0.
ASEGA, AMANDA F. .; MENEZES, MILENE C.; TREVISAN-SILVA, DILZA; CAJADO-CARVALHO, DANIELA; BERTHOLIM, LUCIANA; OLIVEIRA, ANA K.; ZELANIS, ANDRE; SERRANO, SOLANGE M. T. Cleavage of proteoglycans, plasma proteins and the platelet-derived growth factor receptor in the hemorrhagic process induced by snake venom metalloproteinases. SCIENTIFIC REPORTS, v. 10, n. 1 JUL 31 2020. Web of Science Citations: 0.
DE ARAUJO, CHRISTIANE BEZERRA; CHAGAS DA CUNHA, JULIA PINHEIRO; INADA, DAVI TOSHIO; DAMASCENO, JEZIEL; JERONIMO LIMA, ALEX RANIERI; HIRAIWA, PRISCILA; MARQUES, CATARINA; GONCALVES, EVONNILDO; NISHIYAMA-JUNIOR, MILTON YUTAKA; MCCULLOCH, RICHARD; ELIAS, MARIA CAROLINA. Replication origin location might contribute to genetic variability in Trypanosoma cruzi. BMC Genomics, v. 21, n. 1 JUN 22 2020. Web of Science Citations: 0.
MONTONI, FABIO; ANDREOTTI, DIANA ZUKAS; DOS SANTOS EICHLER, ROSANGELA APARECIDA; SANTOS, WELLINGTON DA SILVA; KISAKI, CAROLINA YUKIKO; SUEHIRO ARCOS, STEPHANIE SANTOS; LIMA, ISMAEL FEITOSA; MALTAURO SOARES, MAGNA APARECIDA; NISHIYAMA-JR, MILTON YUTAKA; NAVA-RODRIGUES, DANIEL; FERRO, EMER SUAVINHO; CARVALHO, VALDEMIR MELECHCO; IWAI, LEO KEI. The impact of rattlesnake venom on mice cerebellum proteomics points to synaptic inhibition and tissue damage. JOURNAL OF PROTEOMICS, v. 221, JUN 15 2020. Web of Science Citations: 0.
NAVARRO, MARINA V.; CHAVES, ALISON F. A.; CASTILHO, DANIELE G.; CASULA, ISIS; CALADO, JULIANA C. P.; CONCEICAO, PALLOMA M.; IWAI, LEO K.; DE CASTRO, BEATRIZ F.; BATISTA, WAGNER L. Effect of Nitrosative Stress on theS-Nitroso-Proteome ofParacoccidioides brasiliensis. FRONTIERS IN MICROBIOLOGY, v. 11, JUN 4 2020. Web of Science Citations: 0.
DA SILVA, MARCELO SANTOS; LOPES, PRISCILA HESS; ELIAS, MARIA CAROLINA; TAMBOURGI, V, DENISE. Cytotoxic and genotoxic effects on human keratinocytes triggered by sphingomyelinase D fromLoxoscelesvenom. ARCHIVES OF TOXICOLOGY, JUN 2020. Web of Science Citations: 0.
MOURA-DA-SILVA, ANA MARIA; CONTRERAS-BERNAL, JORGE CARLOS; GIMENES, SARAH NATALIE CIRILO; FREITAS-DE-SOUSA, LUCIANA APARECIDA; PORTES-JUNIOR, JOSE ANTONIO; PEIXOTO, PEDRO DA SILVA; IWAI, LEO KEI; DE MOURA, VALERIA MOURAO; BISNETO, PEDRO FERREIRA; LACERDA, MARCUS; DA SILVA, IRAN MENDONCA; FERREIRA, LUIZ CARLOS DE LIMA; DE OLIVEIRA, SAMELLA SILVA; WEN, FAN HUI; SACHETT, JACQUELINE DE ALMEIDA GONCALVES; MONTEIRO, WUELTON M. The relationship between clinics and the venom of the causative Amazon pit viper (Bothrops atrox). PLoS Neglected Tropical Diseases, v. 14, n. 6 JUN 2020. Web of Science Citations: 0.
LOPES, PRISCILA HESS; VAN DEN BERG, CARMEN W.; TAMBOURGI, V, DENISE. Sphingomyelinases D From Loxosceles Spider Venoms and Cell Membranes: Action on Lipid Rafts and Activation of Endogenous Metalloproteinases. FRONTIERS IN PHARMACOLOGY, v. 11, MAY 13 2020. Web of Science Citations: 0.
DA SILVA, MARCELO S.; VITARELLI, MARCELA O.; SOUZA, BRUNO F.; ELIAS, MARIA CAROLINA. Comparative Analysis of the Minimum Number of Replication Origins in Trypanosomatids and Yeasts. GENES, v. 11, n. 5 MAY 2020. Web of Science Citations: 0.
DE LIMA, LOYZE P.; POUBEL, SALOE BISPO; YUAN, ZUO-FEI; ROSON, JULIANA NUNES; DE LUNA VITORINO, FRANCISCA NATHALIA; HOLETZ, FABIOLA BARBIERI; GARCIA, BENJAMIN A.; CHAGAS DA CUNHA, JULIA PINHEIRO. Improvements on the quantitative analysis of Trypanosoma cruzi histone post translational modifications: Study of changes in epigenetic marks through the parasite's metacyclogenesis and life cycle. JOURNAL OF PROTEOMICS, v. 225, APR 15 2020. Web of Science Citations: 0.
LICHTENSTEIN, FLAVIO; IQBAL, ASIF; ALVES DE LIMA WILL, SONIA ELISABETE; BOSCH, ROSEMARY VIOLA; DEOCESANO-PEREIRA, CARLOS; GOLDFEDER, MAURICIO BARBUGIANI; CHAMMAS, ROGER; MADUREIRA TRUFEN, CARLOS EDUARDO; PEREIRA MORAIS, KATIA LUCIANO; DE SOUZA, JEAN GABRIEL; MENDONCA NATALINO, RENATO JOSE; DE AZEVEDO, INACIO JUNQUEIRA; NISHIYAMA JUNIOR, MILTON YUTAKA; OLIVEIRA, URSULA; ARRUDA ALVES, FRANCISCO IVANIO; ARAUJO, JAQUELINE MAYARA; MAIA LOBBA, ALINE RAMOS; CHUDZINSKI-TAVASSI, ANA MARISA. Modulation of stress and immune response by Amblyomin-X results in tumor cell death in a horse melanoma model. SCIENTIFIC REPORTS, v. 10, n. 1 APR 14 2020. Web of Science Citations: 0.
RICILUCA, K. C. T.; BORGES, A. C.; MELLO, J. F. R.; DE OLIVEIRA, U. C.; SERDAN, D. C.; FLOREZ-ARIZA, A.; CHAPARRO, E.; NISHIYAMA-JR, M. Y.; CASSAGO, A.; JUNQUEIRA-DE-AZEVEDO, I. L. M.; VAN HEEL, M.; SILVA JR, I, P.; PORTUGAL, V, R. Myriapod haemocyanin: the first three-dimensional reconstruction of Scolopendra subspinipes and preliminary structural analysis of S. viridicornis. OPEN BIOLOGY, v. 10, n. 4 APR 1 2020. Web of Science Citations: 0.
ESTRELA, GUSTAVO; GUBITOSO, MARCO DIMAS; FERREIRA, CARLOS EDUARDO; BARRERA, JUNIOR; REIS, MARCELO S. An Efficient, Parallelized Algorithm for Optimal Conditional Entropy-Based Feature Selection. Entropy, v. 22, n. 4 APR 2020. Web of Science Citations: 0.
LOPES, PRISCILA HESS; SQUAIELLA-BAPTISTAO, CARLA CRISTINA; MARQUES, MARIO OCTAVIO THA; TAMBOURGI, DENISE V. Clinical aspects, diagnosis and management of Loxosceles spider envenomation: literature and case review. ARCHIVES OF TOXICOLOGY, v. 94, n. 5 MAR 2020. Web of Science Citations: 1.
PAVANI, RAPHAEL S.; DE LIMA, LOYZE P.; LIMA, ANDRE A.; FERNANDES, CARLOS A. H.; FRAGOSO, STENIO P.; CALDERANO, SIMONE G.; ELIAS, MARIA CAROLINA. Nuclear export of replication protein A in the nonreplicative infective forms of Trypanosoma cruzi. FEBS Letters, v. 594, n. 10 MAR 2020. Web of Science Citations: 0.
ALMEIDA, MICHELLE TEIXEIRA DE; FREITAS-DE-SOUSA, LUCIANA APARECIDA; COLOMBINI, MONICA; GIMENES, SARAH N. C.; KITANO, EDUARDO S.; FAQUIM-MAURO, ELIANA L.; SERRANO, SOLANGE M. T.; MOURA-DA-SILVA, ANA MARIA. Inflammatory Reaction Induced by Two Metalloproteinases Isolated from Bothrops atrox Venom and by Fragments Generated from the Hydrolysis of Basement Membrane Components. TOXINS, v. 12, n. 2 FEB 2020. Web of Science Citations: 0.
LIMA DINIZ, LAURA CRISTINA; SILVA JUNIOR, PEDRO ISMAEL. Hemoglobin Reassembly of Antimicrobial Fragments from the Midgut of Triatoma infestans. BIOMOLECULES, v. 10, n. 2 FEB 2020. Web of Science Citations: 0.
MOREIRA, RAFAEL J.; CASTRO, ERIQUE; OLIVEIRA, TIAGO E.; BELCHIOR, THIAGO; PEIXOTO, ALBERT S.; CHAVES-FILHO, ADRIANO B.; MORENO, MAYARA F.; LIMA, JANAYNA D.; YOSHINAGA, MARCOS; MIYAMOTO, SAYURI; MORAIS, MYCHEL R. P. T.; ZORN, TELMA M. T.; COGLIATI, BRUNO; IWAI, LEO K.; PALMISANO, GIUSEPPE; CABRAL, FERNANDA J.; FESTUCCIA, WILLIAM. Lipoatrophy-Associated Insulin Resistance and Hepatic Steatosis are Attenuated by Intake of Diet Rich in Omega 3 Fatty Acids. MOLECULAR NUTRITION & FOOD RESEARCH, v. 64, n. 7 FEB 2020. Web of Science Citations: 1.
TEIXEIRA, N. B.; SANT'ANNA, M. B.; GIARDINI, A. C.; ARAUJO, L. P.; FONSECA, L. A.; BASSO, A. S.; CURY, Y.; PICOLO, G. Crotoxin down-modulates pro-inflammatory cells and alleviates pain on the MOG(35-55)-induced experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. BRAIN BEHAVIOR AND IMMUNITY, v. 84, p. 253-268, FEB 2020. Web of Science Citations: 0.
ESPINOZA-CULUPU, ABRAHAM; MENDES, ELIZABETH; VITORINO, HECTOR AGUILAR; DA SILVA JR, PEDRO ISMAEL; BORGES, MONAMARIS MARQUES. Mygalin: An Acylpolyamine With Bactericidal Activity. FRONTIERS IN MICROBIOLOGY, v. 10, JAN 10 2020. Web of Science Citations: 0.
SCHMIDT, MARIANA COSTA BRAGA; MORAIS, KATIA L. P.; DE ALMEIDA, MAIRA ESTANISLAU SOARES; IQBAL, ASIF; GOLDFEDER, MAURICIO BARBUGIANI; CHUDZINSKI-TAVASSI, ANA MARISA. Amblyomin-X, a recombinant Kunitz-type inhibitor, regulates cell adhesion and migration of human tumor cells. CELL ADHESION & MIGRATION, v. 14, n. 1, p. 129-138, JAN 1 2020. Web of Science Citations: 6.
DA SILVA, MARCELO S.; CAYRES-SILVA, GUSTAVO R.; VITARELLI, MARCELA O.; MARIN, PAULA A.; HIRAIWA, PRISCILA M.; ARAUJO, CHRISTIANE B.; SCHOLL, BRUNO B.; AVILA, ANDREA R.; MCCULLOCH, RICHARD; REIS, MARCELO S.; ELIAS, MARIA CAROLINA. Transcription activity contributes to the firing of non-constitutive origins in African trypanosomes helping to maintain robustness in S-phase duration. SCIENTIFIC REPORTS, v. 9, DEC 6 2019. Web of Science Citations: 0.
SOUZA, GLAUCIA MENDES; VAN SLUYS, MARIE-ANNE; LEMBKE, CAROLINA GIMILIANI; LEE, HAYAN; MARGARIDO, GABRIEL RODRIGUES ALVES; HOTTA, CARLOS TAKESHI; GAIARSA, JONAS WEISSMANN; DINIZ, AUGUSTO LIMA; OLIVEIRA, MAURO DE MEDEIROS; FERREIRA, SAVIO DE SIQUEIRA; NISHIYAMA, MILTON YUTAKA; TEN-CATEN, FELIPE; RAGAGNIN, GEOVANI TOLFO; ANDRADE, PABLO DE MORAIS; DE SOUZA, ROBSON FRANCISCO; NICASTRO, GIANLUCCA GONCALVES; PANDYA, RAVI; KIM, CHANGSOO; GUO, HUI; DURHAM, ALAN MITCHELL; CARNEIRO, MONALISA SAMPAIO; ZHANG, JISEN; ZHANG, XINGTAN; ZHANG, QING; MING, RAY; SCHATZ, MICHAEL C.; DAVIDSON, BOB; PATERSON, ANDREW H.; HECKERMAN, DAVID. Assembly of the 373k gene space of the polyploid sugarcane genome reveals reservoirs of functional diversity in the world's leading biomass crop. GIGASCIENCE, v. 8, n. 12 DEC 2019. Web of Science Citations: 3.
KUNIYOSHI, ALEXANDRE KAZUO; KODAMA, ROBERTO TADASHI; CAJADO-CARVALHO, DANIELA; IWAI, LEO KEI; KITANO, EDUARDO; FERNANDES DA SILVA, CRISTIANE CASTILHO; DUZZI, BRUNO; DA SILVA, WILMAR DIAS; PORTARO, FERNANDA CALHETA. Experimental antivenom against serine proteases from the Bothrops jararaca venom obtained in mice, and its comparison with the antibothropic serum from the Butantan Institute. Toxicon, v. 169, p. 59-67, NOV 2019. Web of Science Citations: 0.
SILVA, LUIZ E.; SOUZA, RENAN C.; KITANO, EDUARDO S.; MONTEIRO, LUCAS F.; IWAI, LEO K.; FORTI, FABIO L. Proteomic and Interactome Approaches Reveal PAK4, PHB-2, and 14-3-3 eta as Targets of Overactivated Cdc42 in Cellular Responses to Genomic Instability. JOURNAL OF PROTEOME RESEARCH, v. 18, n. 10, p. 3597-3614, OCT 2019. Web of Science Citations: 0.
CHAPARRO-AGUIRRE, ELISA; SEGURA-RAMIREZ, PAULA J.; ALVES, FLAVIO L.; RISKE, KARIN A.; MIRANDA, ANTONIO; SILVA JUNIOR, I, PEDRO. Antimicrobial activity and mechanism of action of a novel peptide present in the ecdysis process of centipede Scolopendra subspinipes subspinipes. SCIENTIFIC REPORTS, v. 9, SEP 20 2019. Web of Science Citations: 0.
DE FREITAS, BARBARA GUIMARAES; PEREIRA, LEANDRO MARCIO; SANTA-CECILIA, FLAVIA VIANNA; HOSCH, NATALIA GABRIELE; PICOLO, GISELE; CURY, YARA; ZAMBELLI, VANESSA O. Mitogen-Activated Protein Kinase Signaling Mediates Morphine Induced-Delayed Hyperalgesia. FRONTIERS IN NEUROSCIENCE, v. 13, SEP 20 2019. Web of Science Citations: 0.
OLIVEIRA, THIAGO DE JESUS; DE OLIVEIRA, URSULA CASTRO; DA SILVA JUNIOR, PEDRO ISMAEL. Serrulin: A Glycine-Rich Bioactive Peptide from the Hemolymph of the Yellow Tityus serrulatus Scorpion. TOXINS, v. 11, n. 9 SEP 2019. Web of Science Citations: 0.
ZELANIS, ANDRE; OLIVEIRA, ANA K.; PRUDOVA, ANNA; HUESGEN, PITTER F.; TASHIMA, ALEXANDRE K.; KIZHAKKEDATHU, JAYACHANDRAN; OVERALL, CHRISTOPHER M.; SERRANO, SOLANGE M. T. Deep Profiling of the Cleavage Specificity and Human Substrates of Snake Venom Metalloprotease HF3 by Proteomic Identification of Cleavage Site Specificity (PICS) Using Proteome Derived Peptide Libraries and Terminal Amine Isotopic Labeling of Substrates (TAILS) N-Terminomics. JOURNAL OF PROTEOME RESEARCH, v. 18, n. 9, p. 3419-3428, SEP 2019. Web of Science Citations: 0.
ZELANIS, ANDRE; SILVA, DEBORA A.; KITANO, EDUARDO S.; LIBERATO, TARCISIO; FUKUSHIMA, ISABELLA; SERRANO, SOLANGE M. T.; TASHIMA, ALEXANDRE K. A first step towards building spectral libraries as complementary tools for snake venom proteome/peptidome studies. Comparative Biochemistry and Physiology D-Genomics & Proteomics, v. 31, SEP 2019. Web of Science Citations: 0.
BENSAOUD, CHAIMA; AOUNALLAH, HAJER; SCIANI, JULIANA MOZER; FARIA, FERNANDA; CHUDZINSKI-TAVASSI, ANA MARISA; BOUATTOUR, ALI; M'GHIRBI, YOUMNA. Proteomic informed by transcriptomic for salivary glands components of the camel tick Hyalomma dromedarii. BMC Genomics, v. 20, n. 1 AUG 27 2019. Web of Science Citations: 0.
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