Advanced search
Start date
Betweenand

CeTICS - Center of Toxins, Immune-Response and Cell Signaling

Grant number: 13/07467-1
Support type:Research Grants - Research, Innovation and Dissemination Centers - RIDC
Duration: July 01, 2013 - June 30, 2024
Field of knowledge:Biological Sciences - Biochemistry - Molecular Biology
Principal researcher:Hugo Aguirre Armelin
Grantee:Hugo Aguirre Armelin
Home Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Pesquisadores principais:
( Atuais )
Denise Vilarinho Tambourgi ; Gisele Picolo ; Inácio de Loiola Meirelles Junqueira de Azevedo ; Monica Valdyrce dos Anjos Lopes Ferreira ; Solange Maria de Toledo Serrano ; Wilmar Dias da Silva
Pesquisadores principais:
( Anteriores )
Ana Marisa Chudzinski-Tavassi ; Junior Barrera ; Maria Carolina Quartim Barbosa Elias Sabbaga ; Osvaldo Augusto Brazil Esteves Sant'Anna ; Yara Cury
Assoc. researchers:Adriana Mortara Almeida ; Alessandra Fernandes Bizerra ; Alexandre Keiji Tashima ; Aline Soriano Lopes ; Allan Mowat ; Ana Maria Moura da Silva ; Ana Marisa Chudzinski-Tavassi ; André Zelanis Palitot Pereira ; Ann Ager ; B. Paul Morgan ; Carla Cristina Squaiella ; Carla Lima da Silva ; Carmen W. Van Den Berg ; Daria Mochly-Rosen ; Denise Vilarinho Tambourgi ; Fabio Carlos Magnoli ; Fábio Nakano ; Fan Hui Wen ; Fernanda Calheta Vieira Portaro ; Fernanda Faria ; Fernanda Paiva Guimarães ; Gisele Picolo ; Giselle Pidde Marques Porto ; Inácio de Loiola Meirelles Junqueira de Azevedo ; Jay W. Fox ; Jesus Aparecido Ferro ; Jose Roberto Marcelino ; Jose Salvatore Leister Patane ; Julia Pinheiro Chagas da Cunha ; Katsuhiro Konno ; Kerly Fernanda Mesquita Pasqualoto ; Leo Kei Iwai ; Luc Pellerin ; Luciana Rodrigues Gomes ; Luiz Vicente Rizzo ; Marcella Barbosa Faria de Almeida Prado ; Marcelo da Silva Reis ; Marcelo de Franco ; Marcia Carvalho de Abreu Fantini ; Marcio Henrique Zaim ; Maria Carolina Quartim Barbosa Elias Sabbaga ; Maria Teresa Machini ; Marinilce Fagundes dos Santos ; Martha Marandino ; Miguel Allende ; Milton Yutaka Nishiyama Junior ; Mirta Schattner ; Miryam Paola Alvarez Flores ; Ovidiu Radulescu ; Paulo Lee Ho ; Paulo Sérgio Lacerda Beirão ; Pedro Ismael da Silva Junior ; Ricardo Jose Giordano ; Richard Mcculloch ; Robson Lopes de Melo ; Roger Chammas ; Ruy Gastaldoni Jaeger ; Sandra Coccuzzo Sampaio Vessoni ; Silvio Roberto de Azevedo Salinas ; Simone Guedes Calderano ; Sonia Aparecida de Andrade Chudzinski ; Tânia Tomé Martins de Castro ; Vanessa Olzon Zambelli ; Vanessa Rioli
Associated grant(s):19/23605-1 - Towards identification of molecular mechanisms of resistance to drugs and DNA reparation in Trypanosomatidae, AP.R SPRINT
21/13951-0 - Multi-user equipment approved in grant 13/07467-1: FacsLyric Flow Cytometer and accessories - Becton Dickinson, AP.EMU
21/13939-0 - Multi-user equipment approved in grant 13/07467-1: Orbitrap Exploris 480 Mass Spectrometer and accessories, AP.EMU
+ associated grants 19/07809-6 - ICOM CECA Conference 2019: Roles of Museum Education: Supporting Self and Society, AR.EXT
18/26586-5 - 24th World Congress of Dermatology of the International League of Dermatology Societies, AR.EXT
17/18281-7 - Multi-user equipment approved in grant 2013/07467-1 - system of NanoLC EASY-nLCTM 1000 - thermo scientific, AP.EMU
15/10413-6 - ICOM CECA Annual Conference 2015: Museum Education and Accessibility: Bridging the Gaps, AR.EXT
15/07553-0 - Multi-User Equipment approved in grant 2013/07467-1 : Biacore T200 Surface Plasmon Resonance System, AP.EMU
15/10037-4 - Multi-User Equipment approved in grant 2013/07467-1: flow cytometer, AP.EMU - associated grants
Associated scholarship(s):21/10570-5 - Molecular characterization of the in vivo effects of Bothrops jararaca venom: analysis of mouse muscle tissue and plasma, by proteomic and immunohistochemical approaches, BP.PD
21/10344-5 - Identification of crotoxin-derived peptides with antitumor and immunomodulatory potential, BP.PD
19/24580-2 - Bayesian dynamic model selection of non-isolated cell signaling pathways, BP.DD
+ associated scholarships 21/08891-8 - Assessment of the pharmacological mechanisms of the peptide TnP isolated from Thalassophryne nattereri venom in the therapy of Hypoxic Retinopathy in Zebrafish, BP.PD
21/04355-4 - Efficient implementations of Bayesian methods for cell signaling pathway model selection, BP.IC
20/11468-7 - New Tools Management and Implementation for the CeTICSDB Platform, BP.TT
20/12317-2 - Proteomic analysis of the systemic effects of Bothrops jararaca venom in a murine model, BP.PD
19/27348-3 - Complement system inhibition as means for controlling inflammation associated to envenomations, BP.PD
20/03718-3 - Understanding the local reactions induced by Loxosceles venoms and their main toxins, BP.PD
20/00770-4 - Synthesis of benznidazole and graphene oxide derivatives and evaluation of their anti-chagasic activities, BP.PD
19/27677-7 - Study of the induction of regulatory microRNAs by TNP dependent on Aryl hydrocarbon Receptor (AhR) activation, BP.PD
19/20025-4 - An approximate Bayesian computation-based approach to tackle the lack of isolation problem in signaling pathway modeling, BE.PQ
19/18565-0 - Evaluation by quantitative in situ hybridization of the transcript levels of Natterin-like in CRISPR/Cas-9 depleted zebrafish, BP.IC
19/10500-7 - EVALUATION OF INFLAMMASOME REQUIREMENT IN NEUTROPHILIC INFLAMMATION INDUCED BY PORE-FORMING TOXINS, NATTERINS, BE.PQ
19/05882-8 - The role of crotalphine in the primary cilium dynamics of primary afferent neurons: novel insights for the study of analgesic compounds, BP.PD
19/13039-9 - Cell cycle control in normal and malignant cells, new approach in cancer therapy., BP.PD
19/01895-8 - Function of the MRE11, DNA2 and EXO1 nucleases in DNA end resection and double-strand breaks repair in Trypanosoma brucei, BP.PD
19/02333-3 - Validation of the functional importance of natterins in the innate immune response in zebrafish by CRISPR-Cas9, a loss-of-function method, BP.MS
18/06751-1 - Molecular characterization of the in vivo effects of the hemorrhagic metalloproteinase HF3: analyses of the proteome of mice muscle tissue, BP.MS
18/12364-0 - Expression, purification and initial characterization of a new RPA-like protein in Trypanosoma brucei, BP.IC
17/07693-2 - Functional dynamics of Orc1b protein during the life cycle of Trypanosoma, BP.DR
18/08167-5 - Bioinformatic support for differential gene expression projects of CeTICS, BP.TT
18/06682-0 - Computational phylogenetic analysis of Bothrops snakes from venom proteomes, BP.IC
17/06496-9 - Proteomic characterization of the effect of Bothrops jararaca snake venom on normal vs cancer cell lines, BP.MS
17/20575-9 - Identification of cell signaling pathways based on biochemical reaction kinetics repositories, BP.MS
17/18344-9 - Quantitative chromatin proteomics upon FGF2 treatment: analysis of transcriptional regulation and involvement of cdc42, BP.DD
17/19252-0 - Proteomic analysis of the effects of PA-BJ, a serine proteinase of Bothrops jararaca venom, upon peripheral blood endothelial cell culture, BP.PD
17/19545-8 - Analysis of molecular mechanisms underlying FGF2 cell cycle inhibition in mouse Y1 adrenocortical and tumor cells dependent of amplified WT-Kras, BP.PD
17/09929-3 - Bothrops snake venoms: impact of glycosylation on the complexity of proteomes and toxins function, BP.DD
17/12199-7 - Loxoscelism: from basic research to the proposal of new therapies, BP.TT
17/09648-4 - Recombinant expression, and functional characterization of the non-catalytic domains of a P-III class metalloproteinase from Bothrops jararaca snake venom, using a cell-free expression system, BP.IC
16/25959-7 - Design of poset forest-based algorithms for the U-curve optimization problem, BP.IC
16/22774-6 - Epigenetic control in opioid receptor-dependent analgesia: role of miRNA and DNA methylation on the crotalphine antinociceptive effect, BP.PD
17/00715-0 - Proteolytic enzymes from snake venoms trigger cascades of yet unknown molecular events, BP.PD
16/17775-3 - Design and simulation of computational models of the DNA replication dynamics in kinetoplastids, BP.IC
16/16935-7 - A post-translational modification perspective of Bothrops venom toxins: site-specific proteomic characterization of N-glycans and Cys residues., BP.DR
15/12224-6 - Evaluation the mechanisms involved in the survival of long-lived antibody-secreting cells induced by IL-17- released from neutrophil extracellular traps, BE.PQ
16/10613-8 - Analysis of complement system action on micro RNAs expression in systemic loxoscelism, BP.PD
16/07802-3 - Antivenom design based on amino acid sequence of complementarity determining regions (CDRs), BP.PD
15/23691-4 - Pro-inflammatory activity of snake venom proteinases: i)expression of recombinant proteinases in a cell-free system; ii) generation of microvesicles by monocytes stimulated with native and recomb proteinases, and analysis of their interaction with end cells, BP.PD
15/17053-5 - Study of inflamassomes activation, in human keratinocytes, by Loxosceles laeta spider venom and its sphingomyelinase D, BP.PD
15/03509-7 - Genomic sequencing of Brazilian snakes focused on the study of toxins, BP.PD
15/17494-1 - Loxoscelism: from basic research to the proposal of new therapies, BP.PD
15/01234-0 - Proteolytic enzymes from snake venoms trigger cascades of yet unknown molecular events, BP.PD
14/24170-5 - DNA replication dynamics in Trypanosoma cruzi: licensing and replication rate characterization, BP.PD
15/04641-6 - Investigation of the role of desensitization on Natterin antagonism, BP.IC
15/03953-4 - Integrin expression modulation in neutrophils by Natterins, BP.IC
14/02978-0 - Functional analysis of RPA complex in Trypanosoma cruzi and its involvement with telomeric DNA, BP.DR
14/23564-0 - Studies of efficient data structures to tackle the U-curve optimization problem, BP.IC
14/21557-6 - Functional analysis of Ataxia-telangiectasia mutated (ATM) and Ataxia-telangiectasia and RAD3-related (ATR) in DNA damage response in Trypanosoma cruzi, BP.IC
14/18875-6 - Pain and analgesia: molecular mechanisms of new therapeutic drugs and targets, BP.PD
14/13375-5 - Replication origins in trypanosomes, BP.PD
14/01534-1 - Characterization of the inhibition potential of collagen receptor Discoiding domain receptor 2 by snake venom metalloproteases components, BE.PQ
13/24212-7 - Bioinformatics and modelling, BP.PD
13/50694-9 - Evaluation of NET role released by neutrophils in differentiation of long-lived antibody-producing cells in chronic response induced by Thalassophryne nattereri venom, BP.PD
13/07974-0 - Sequencing of Bothrops jararaca genome to characterize toxins gene structure and their regulatory elements, BP.DR
12/51135-0 - Natterins induction verification of TLR signaling pathway regulatory mechanisms, BP.PD
12/20186-9 - Molecular mechanisms of functional interaction between Ras and cyclin D1 in Ras-driven malignant cells, BP.PD
11/09333-7 - Crotalphine: fluorescent analogues and study of mechanism of action in cultures and co-cultures of neurons and keratinocytes, BP.PD - associated scholarships

Abstract

Toxinology and regulation of the lmmune-response are two interconnected classical areas of scientific investigation around which the Butantan Institute historically built its strong international reputation. Indeed, it is deeply rooted in the culture of Butantan lnstitute, the notion that toxins are components in complex venoms, which were selected by evolution to exert concerted systemic biological effects through highly specific biochemical, molecular and cellular mechanisms. As a corollary to this notion, isolation and chemical characterization of venom components very likely can yield novel toxin molecules with high therapeutic potential. Following this historical tradition, in the last 10 years, investigators of the Center for Applied Toxinology (CAT CEPID project) successfully isolated, chemically characterized and patented several novel protein and peptide toxins, which became starting points for development of pharmaceutical innovations in partnership with local industries. This emphasis on proteins and peptides led to deployment of state of the art laboratories for proteomics, transcriptomics, molecular biology of recombinant DNA and peptide synthesis. More recently, studies of biochemical, molecular and cellular mechanisms of hopeful therapeutic drugs were initiated, aiming to establish proofs of concept. Thus, the CAT project has progressively paved the way towards a systems biology oriented center of toxins, immune-response and cell signaling at Butantan lnstitute. The present proposal aims to establish the new Center of Toxins, lmmune-response and Cell Signaling – CeTICS - as a world class center of excellence, taking advantage of the Butantan lnstitute historical international reputation and, also, the research successes and infrastructure legacy of the CAT CEPID project. To this end 10 investigators, representative of the most competitive leaders of research in the Butantan lnstitute, designed a Center's ambitious research plan focused on integration of subprojects biased towards scientific research and subprojects motivated for technological innovations. A large group of senior scientists from Butantan lnstitute, from other Brazilian institutions and, also, from well-known foreign institutions will be collaborators of the Center. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (199)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GONCALVES LUCHINI, LYGIA SAMARTIN; PIDDE, GISELLE; SQUAIELLA-BAPTISTAO, CARLA CRISTINA; TAMBOURGI, DENISE V.. Complement System Inhibition Modulates the Pro-Inflammatory Effects of a Snake Venom Metalloproteinase. FRONTIERS IN IMMUNOLOGY, v. 10, . (13/07467-1, 13/26198-1)
GREN, ERIC C. K.; KITANO, EDUARDO S.; ANDRADE-SILVA, DEBORA; IWAI, LEO KEI; REIS, MARCELO S.; MENEZES, MILENE C.; SERRANO, SOLANGE M. T.. Comparative analysis of the high molecular mass subproteomes of eight Bothrops snake venoms. Comparative Biochemistry and Physiology D-Genomics & Proteomics, v. 30, p. 113-121, . (13/07467-1, 15/01234-0, 13/13548-4)
OLIVEIRA, THIAGO DE JESUS; DE OLIVEIRA, URSULA CASTRO; DA SILVA JUNIOR, PEDRO ISMAEL. Serrulin: A Glycine-Rich Bioactive Peptide from the Hemolymph of the Yellow Tityus serrulatus Scorpion. TOXINS, v. 11, n. 9, . (13/07467-1)
KUNIYOSHI, ALEXANDRE KAZUO; KODAMA, ROBERTO TADASHI; CAJADO-CARVALHO, DANIELA; IWAI, LEO KEI; KITANO, EDUARDO; FERNANDES DA SILVA, CRISTIANE CASTILHO; DUZZI, BRUNO; DA SILVA, WILMAR DIAS; PORTARO, FERNANDA CALHETA. Experimental antivenom against serine proteases from the Bothrops jararaca venom obtained in mice, and its comparison with the antibothropic serum from the Butantan Institute. Toxicon, v. 169, p. 59-67, . (15/13124-5, 13/07467-1, 13/15344-7, 12/06677-0, 15/15364-3)
SILVA, LUIZ E.; SOUZA, RENAN C.; KITANO, EDUARDO S.; MONTEIRO, LUCAS F.; IWAI, LEO K.; FORTI, FABIO L.. Proteomic and Interactome Approaches Reveal PAK4, PHB-2, and 14-3-3 eta as Targets of Overactivated Cdc42 in Cellular Responses to Genomic Instability. JOURNAL OF PROTEOME RESEARCH, v. 18, n. 10, p. 3597-3614, . (13/07467-1, 18/01753-6)
REIS, MARCELO S.; ESTRELA, GUSTAVO; FERREIRA, CARLOS EDUARDO; BARRERA, JUNIOR. featsel: A framework for benchmarking of feature selection algorithms and cost functions. SOFTWAREX, v. 6, p. 193-197, . (16/25959-7, 13/07467-1, 13/03447-6, 15/01587-0)
REIS, MARCELO S.; ESTRELA, GUSTAVO; FERREIRA, CARLOS EDUARDO; BARRERA, JUNIOR. Optimal Boolean lattice-based algorithms for the U-curve optimization problem. INFORMATION SCIENCES, v. 471, p. 97-114, . (13/07467-1, 11/50761-2, 14/23564-0)
MANZONI-DE-ALMEIDA, DANIEL; SQUAIELLA-BAPTISTAO, CARLA CRISTINA; LOPES, PRISCILA HESS; VAN DEN BERG, CARMEN W.; TAMBOURGI, DENISE V.. Loxosceles venom Sphingomyelinase D activates human blood leukocytes: Role of the complement system. Molecular Immunology, v. 94, p. 45-53, . (13/07467-1, 15/17053-5)
VALENTE, RICHARD HEMMI; LUNA, MILENE SCHMIDT; DE OLIVEIRA, URSULA CASTRO; NISHIYAMA-JUNIOR, MILTON YUTAKA; JUNQUEIRA-DE-AZEVEDO, INACIO DE LOIOLA; PORTES-JUNIOR, JOSE ANTONIO; CLISSA, PATRICIA BIANCA; VIANA, LUCIANA GODOY; SANCHES, LEONARDO; MOURA-DA-SILVA, ANA MARIA; et al. Bothrops jararaca accessory venom gland is an ancillary source of toxins to the snake. JOURNAL OF PROTEOMICS, v. 177, p. 137-147, . (13/07467-1, 14/26058-8, 16/50127-5)
DE ARAUJO, CHRISTIANE BEZERRA; DE LIMA, LOYZE PAOLA; CALDERANO, SIMONE GUEDES; DAMASCENO, FLAVIA SILVA; SILBER, ARIEL M.; ELIAS, MARIA CAROLINA. Pep5, a Fragment of Cyclin D2, Shows Antiparasitic Effects in Different Stages of the Trypanosoma cruzi Life Cycle and Blocks Parasite Infectivity. Antimicrobial Agents and Chemotherapy, v. 63, n. 5, . (14/13375-5, 16/50050-2, 17/16553-0, 13/07467-1, 16/06034-2)
DOS SANTOS, JULIANE MONTEIRO; DOS SANTOS, JANAINA CARDOSO; MARQUES, ELINEIDE EUGENIO; DE ARAUJO, GESSI CARVALHO; SEIBERT, CARLA SIMONE; LOPES-FERREIRA, MONICA; CARLA, LIMA. Stingray (Potamotrygon rex) maturity is associated with inflammatory capacity of the venom. Toxicon, v. 163, p. 74-83, . (13/07467-1)
SILVA-DE-FRANCA, FELIPE; VILLAS-BOAS, ISADORA MARIA; DE TOLEDO SERRANO, SOLANGE MARIA; COGLIATI, BRUNO; DE ANDRADE CHUDZINSKI, SONIA APARECIDA; LOPES, PRISCILA HESS; KITANO, EDUARDO SHIGUEO; OKAMOTO, CINTHYA KIMORI; TAMBOURGI, DENISE V.. Naja annulifera Snake: New insights into the venom components and pathogenesis of envenomation. PLoS Neglected Tropical Diseases, v. 13, n. 1, . (13/07467-1)
DA SILVA, MARCELO S.; MARINI, PAULA A.; REPOLES, BRUNO M.; ELIAS, MARIA C.; MACHADO, CARLOS R.. Analysis of DNA Exchange Using Thymidine Analogs (ADExTA) in Trypanosoma cruzi. BIO-PROTOCOL, v. 8, n. 24, . (13/07467-1, 14/24170-5, 17/18719-2)
MENEGUELLO, LETICIA; BARBOSA, NATALIA M.; PEREIRA, KARINA D.; PROENCA, ANDRE R. G.; TAMBORLIN, LETICIA; SIMABUCO, FERNANDO M.; IWAI, LEO K.; ZANELLI, CLESLEI F.; VALENTINI, SANDRO R.; LUCHESSI, AUGUSTO D.. The polyproline-motif of S6K2: eIF5A translational dependence and importance for protein-protein interactions. Journal of Cellular Biochemistry, v. 120, n. 4, p. 6015-6025, . (13/07467-1, 12/13558-7, 10/18095-0)
DE OLIVEIRA, URSULA CASTRO; NISHIYAMA, JR., MILTON YUTAKA; VIANA DOS SANTOS, MARIA BEATRIZ; SANTOS-DA-SILVA, ANDRIA DE PAULA; CHALKIDIS, HIPOCRATES DE MENEZES; SOUZA-IMBERG, ANDREIA; CANDIDO, DENISE MARIA; YAMANOUYE, NORMA; CORONADO DORCE, VALQUIRIA ABRAO; MEIRELLES JUNQUEIRA-DE-AZEVEDO, INACIO DE LOIOLA. Proteomic endorsed transcriptomic profiles of venom glands from Tityus obscurus and T. serrulatus scorpions. PLoS One, v. 13, n. 3, . (13/07467-1)
RIBEIRO, KLEBER SILVA; VASCONCELLOS, CAMILLA IOSHIDA; SOARES, RODRIGO PEDRO; MENDES, MARIA TAYS; ELLIS, CAMERON C.; AGUILERA-FLORES, MARCELA; DE ALMEIDA, IGOR CORREIA; SCHENKMAN, SERGIO; IWAI, LEO KEI; TORRECILHAS, ANA CLAUDIA. Proteomic analysis reveals different composition of extracellular vesicles released by two Trypanosoma cruzi strains associated with their distinct interaction with host cells. JOURNAL OF EXTRACELLULAR VESICLES, v. 7, n. 1, . (13/07467-1)
TORRES-BONILLA, KRISTIAN A.; ANDRADE-SILVA, DEBORA; SERRANO, SOLANGE M. T.; HYSLOP, STEPHEN. Biochemical characterization of venom from Pseudoboa neuwiedii (Neuwied's false boa; Xenodontinae; Pseudoboini). COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, v. 213, p. 27-38, . (13/07467-1)
DIAZ-ROA, ANDREA; PATARROYO, MANUEL A.; BELLO, FELIO J.; DA SILVA, JR., PEDRO I.. Sarconesin: Sarconesiopsis magellanica Blowfly Larval Excretions and Secretions With Antibacterial Properties. FRONTIERS IN MICROBIOLOGY, v. 9, . (13/07467-1)
OKAMOTO, CINTHYA KIMORI; VAN DEN BERG, CARMEN W.; MASASHI, MIZUNO; GONCALVES-DE-ANDRADE, RUTE M.; TAMBOURGI, DENISE V.. Tetracycline Reduces Kidney Damage Induced by Loxosceles Spider Venom. TOXINS, v. 9, n. 3, . (13/07467-1)
FERNANDES SILVA, CRISTIANE CASTILHO; MENEZES, MILENE CRISTINA; PALOMINO, MIRYAM; OLIVEIRA, ANA KARINA; IWAI, LEO KEI; FARIA, MARCELLA; PORTARO, FERNANDA VIEIRA. Peptides derived from plasma proteins released by bothropasin, a metalloprotease present in the Bothrops jararaca venom. Toxicon, v. 137, p. 65-72, . (14/02788-7, 13/07467-1, 15/15364-3)
KUNIYOSHI, ALEXANDRE KAZUO; KODAMA, ROBERTO TADASHI; FERREIRA MORAES, LUIS HENRIQUE; DUZZI, BRUNO; IWAI, LEO KEI; LIMA, ISMAEL FEITOSA; CAJADO-CARVALHO, DANIELA; PORTARO, FERNANDA VIEIRA. In vitro cleavage of bioactive peptides by peptidases from Bothrops jararaca venom and its neutralization by bothropic antivenom produced by Butantan Institute: Major contribution of serine peptidases. Toxicon, v. 137, p. 114-119, . (13/07467-1, 13/15344-7, 15/13124-5, 12/06677-0, 15/15364-3)
MONTE, ELISABETE R. C.; ROSSATO, CRISTIANO; LLANOS, RICARDO PARIONA; RUSSO, LILIAN C.; DE CASTRO, LEANDRO M.; GOZZO, FABIO C.; DE ARAUJO, CHRISTIANE B.; PERON, JEAN PIERRE S.; SANT'ANNA, OSVALDO AUGUSTO; FERRO, EMER S.; et al. Interferon-gamma activity is potentiated by an intracellular peptide derived from the human 19S ATPase regulatory subunit 4 of the proteasome. JOURNAL OF PROTEOMICS, v. 151, n. SI, p. 74-82, . (13/07467-1)
CANDIDO-FERREIRA, IVAN LAVANDER; KRONENBERGER, THALES; ROSA SAYEGH, RAPHAEL SANTA; CORREIA BATISTA, ISABEL DE FATIMA; DA SILVA JUNIOR, PEDRO ISMAEL. Evidence of an Antimicrobial Peptide Signature Encrypted in HECT E3 Ubiquitin Ligases. FRONTIERS IN IMMUNOLOGY, v. 7, . (14/03644-9, 13/07467-1)
BRESSAN, ELISANGELA; TOUSKA, FILIP; VETTER, IRINA; KISTNER, KATRIN; KICHKO, TATJANA I.; TEIXEIRA, NATHALIA B.; PICOLO, GISELE; CURY, YARA; LEWIS, RICHARD J.; FISCHER, MICHAEL J. M.; et al. Crotalphine desensitizes TRPA1 ion channels to alleviate inflammatory hyperalgesia. Pain, v. 157, n. 11, p. 2504-2516, . (08/57898-0, 12/51458-4, 13/07467-1, 98/14307-9)
GIRARD, RICHARD M. B. M.; CRISPIM, MARCELL; STOLIC, IVANA; DAMASCENO, FLAVIA SILVA; DA SILVA, MARCELO SANTOS; FURUSHO PRAL, EIZABETH MIEKO; ELIAS, MARIA CAROLINA; BAJIC, MIROSLAV; SILBER, ARIEL MARIANO. An Aromatic Diamidine That Targets Kinetoplast DNA, Impairs the Cell Cycle in Trypanosoma cruzi, and Diminishes Trypomastigote Release from Infected Mammalian Host Cells. Antimicrobial Agents and Chemotherapy, v. 60, n. 10, p. 5867-5877, . (13/07467-1, 13/18970-6)
AUGUSTO-DE-OLIVEIRA, CESAR; STUGINSKI, DANIEL R.; KITANO, EDUARDO S.; ANDRADE-SILVA, DEBORA; LIBERATO, TARCISIO; FUKUSHIMA, ISABELLA; SERRANO, SOLANGE M. T.; ZELANIS, ANDRE. Dynamic Rearrangement in Snake Venom Gland Proteome: Insights into Bothrops jararaca Intraspecific Venom Variation. JOURNAL OF PROTEOME RESEARCH, v. 15, n. 10, p. 3752-3762, . (13/07467-1, 14/06579-3)
BOSCH, ROSEMARY VIOLA; ALVAREZ-FLORES, MIRYAM PAOLA; MARIA, DURVANEI AUGUSTO; CHUDZINSKI-TAVASSI, ANA MARISA. Hemolin triggers cell survival on fibroblasts in response to serum deprivation by inhibition of apoptosis. BIOMEDICINE & PHARMACOTHERAPY, v. 82, p. 537-546, . (13/07467-1, 13/06892-0, 15/50040-4)
DINIZ, V, MARCELO R.; PAIVA, ANA L. B.; GUERRA-DUARTE, CLARA; NISHIYAMA JR, MILTON Y.; MUDADU, MAURICIO A.; DE OLIVEIRA, URSULA; BORGES, MARCIA H.; YATES, JOHN R.; JUNQUEIRA-DE-AZEVEDO, INACIO DE L.. An overview of Phoneutria nigriventer spider venom using combined transcriptomic and proteomic approaches. PLoS One, v. 13, n. 8, . (13/07467-1)
MORAIS, KATIA L. P.; FERNANDES PACHECO, MARIO THIEGO; BERRA, CAROLINA MARIA; BOSCH, ROSEMARY V.; SCIANI, JULIANA MOZER; CHAMMAS, ROGER; SAITO, RENATA DE FREITAS; IQBAL, ASIF; CHUDZINSKI-TAVASSI, ANA MARISA. Amblyomin-X induces ER stress, mitochondrial dysfunction, and caspase activation in human melanoma and pancreatic tumor cell. Molecular and Cellular Biochemistry, v. 415, n. 1-2, p. 119-131, . (10/07958-7, 98/14307-9, 11/05969-4, 13/07467-1)
LEANDRO DE JESUS, TERESA CRISTINA; NUNES, VINICIUS SANTANA; LOPES, MARIANA DE CAMARGO; MARTIL, DAIANA EVELIN; IWAI, LEO KEI; MORETTI, NILMAR SILVIO; MACHADO, FABRICIO CASTRO; DE LIMA-STEIN, MARIANA L.; THIEMANN, OTAVIO HENRIQUE; ELIAS, MARIA CAROLINA; et al. Chromatin Proteomics Reveals Variable Histone Modifications during the Life Cycle of Trypanosoma cruzi. JOURNAL OF PROTEOME RESEARCH, v. 15, n. 6, p. 2039-2051, . (14/01577-2, 15/04867-4, 11/22619-7, 14/03714-7, 11/06087-5, 11/51973-3, 13/07467-1, 08/57910-0)
DREWES, C. C.; DIAS, R. Y.; BRANCO, V. G.; CAVALCANTE, M. F.; SOUZA, J. G.; ABDALLA, D. S. P.; CHUDZINSKI-TAVASSI, A. M.; FARSKY, S. H. P.. Post-transcriptional control of Amblyomin-X on secretion of vascular endothelial growth factor and expression of adhesion molecules in endothelial cells. Toxicon, v. 101, p. 1-10, . (12/06944-8, 10/19802-1, 09/08584-6, 13/07467-1)
YAMASHIRO, EDSON T.; OLIVEIRA, ANA K.; KITANO, EDUARDO S.; MENEZES, MILENE C.; JUNQUEIRA-DE-AZEVEDO, INACIO L.; LEME, ADRIANA F. PAES; SERRANO, SOLANGE M. T.. Proteoforms of the platelet-aggregating enzyme PA-BJ, a serine proteinase from Bothrops jararaca venom. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, v. 1844, n. 12, p. 2068-2076, . (13/07467-1, 11/08514-8, 98/14307-9, 11/11308-0)
SERRANO, SOLANGE M. T.; OLIVEIRA, ANA K.; MENEZES, MILENE C.; ZELANIS, ANDRE. The proteinase-rich proteome of Bothrops jararaca venom. Toxin Reviews, v. 33, n. 4, p. 169-184, . (13/07467-1, 10/17328-0)
PACHECO, MARIO T. F.; MORAIS, KATIA L. P.; BERRA, CAROLINA M.; DEMASI, MARILENE; SCIANI, JULIANA M.; BRANCO, VANIA G.; BOSCH, ROSEMARY V.; IQBAL, ASIF; CHUDZINSKI-TAVASSI, ANA MARISA. Specific role of cytoplasmic dynein in the mechanism of action of an antitumor molecule, Amblyomin-X. Experimental Cell Research, v. 340, n. 2, p. 248-258, . (13/07467-1, 10/07958-7, 11/05969-4)
TANAKA, GABRIELA D.; SANT'ANNA, OSVALDO AUGUSTO; MARCELINO, JOSE ROBERTO; LUSTOZA DA LUZ, ANA CRISTINA; TEIXEIRA DA ROCHA, MARISA MARIA; TAMBOURGI, DENISE V.. Micrurus snake species: Venom immunogenicity, antiserum cross-reactivity and neutralization potential. Toxicon, v. 117, p. 59-68, . (13/07467-1)
PARIONA-LLANOS, RICARDO; PAVANI, RAPHAEL SOUZA; REIS, MARCELO; NOEL, VINCENT; SILBER, ARIEL MARIANO; ARMELIN, HUGO AGUIRRE; CANO, MARIA ISABEL NOGUEIRA; ELIAS, MARIA CAROLINA. Glyceraldehyde 3-Phosphate Dehydrogenase-Telomere Association Correlates with Redox Status in Trypanosoma cruzi. PLoS One, v. 10, n. 3, . (13/07467-1)
JUNQUEIRA-DE-AZEVEDO, INACIO L. M.; VAL BASTOS, CAROLINA MANCINI; HO, PAULO LEE; LUNA, MILENE SCHMIDT; YAMANOUYE, NORMA; CASEWELL, NICHOLAS R.. Venom-Related Transcripts from Bothrops jararaca Tissues Provide Novel Molecular Insights into the Production and Evolution of Snake Venom. Molecular Biology and Evolution, v. 32, n. 3, p. 754-766, . (13/07467-1, 12/00177-5)
LOPES-FERREIRA, MONICA; SOSA-ROSALES, INES; BRUNI, FERNANDA M.; RAMOS, ANDERSON D.; VIEIRA PORTARO, FERNANDA CALHETA; CONCEICAO, KATIA; LIMA, CARLA. Analysis of the intersexual variation in Thalassophryne maculosa fish venoms. Toxicon, v. 115, p. 70-80, . (13/07467-1)
BERTHOLIM, LUCIANA; ZELANIS, ANDRE; OLIVEIRA, ANA K.; SERRANO, SOLANGE M. T.. Proteome-derived peptide library for the elucidation of the cleavage specificity of HF3, a snake venom metalloproteinase. Amino Acids, v. 48, n. 5, p. 1331-1335, . (13/07467-1, 11/16623-1)
ZELANIS, ANDRE; MENEZES, MILENE C.; KITANO, EDUARDO S.; LIBERATO, TARCISIO; TASHIMA, ALEXANDRE K.; PINTO, ANTONIO F. M.; SHERMAN, NICHOLAS E.; HO, PAULO L.; FOX, JAY W.; SERRANO, SOLANGE M. T.. Proteomic identification of gender molecular markers in Bothrops jararaca venom. JOURNAL OF PROTEOMICS, v. 139, p. 26-37, . (13/13548-4, 98/14307-9, 13/07467-1)
FREITAS-DE-SOUSA, L. A.; AMAZONAS, D. R.; SOUSA, L. F.; SANT'ANNA, S. S.; NISHIYAMA, JR., M. Y.; SERRANO, S. M. T.; JUNQUEIRA-DE-AZEVEDO, I. L. M.; CHALKIDIS, H. M.; MOURA-DA-SILVA, A. M.; MOURAO, R. H. V.. Comparison of venoms from wild and long-term captive Bothrops atrox snakes and characterization of Batroxrhagin, the predominant class PIII metalloproteinase from the venom of this species. Biochimie, v. 118, p. 60-70, . (13/07467-1, 12/16277-9, 14/26058-8)
BUENO, VALQUIRIA; SANT'ANNA, OSVALDO AUGUSTO; LORD, JANET M.. Ageing and myeloid-derived suppressor cells: possible involvement in immunosenescence and age-related disease. AGE, v. 36, n. 6, . (12/51747-6, 13/07467-1)
DIAZ-ROA, ANDREA; ESPINOZA-CULUPU, ABRAHAM; TORRES-GARCIA, ORLANDO; BORGES, MONAMARIS M.; AVINO, IVAN N.; ALVES, FLAVIO L.; MIRANDA, ANTONIO; PATARROYO, MANUEL A.; DA SILVA, JR., PEDRO I.; BELLO, FELIO J.. Sarconesin II, a New Antimicrobial Peptide Isolated from Sarconesiopsis magellanica Excretions and Secretions. Molecules, v. 24, n. 11, . (13/07467-1)
PAVANI, RAPHAEL SOUZA; VITARELLI, MARCELA O.; FERNANDES, CARLOS A. H.; MATTIOLI, FABIO F.; MORONE, MARIANA; MENEZES, MILENE C.; FONTES, MARCOS R. M.; CANO, MARIA ISABEL N.; ELIAS, MARIA CAROLINA. Replication Protein A-1 Has a Preference for the Telomeric G-rich Sequence in Trypanosoma cruzi. Journal of Eukaryotic Microbiology, v. 65, n. 3, p. 345-356, . (15/10580-0, 13/07467-1, 14/02978-0)
ANDRADE-SILVA, DEBORA; ASHLINE, DAVID; TRAN, THUY; LOPES, ALINE SORIANO; TRAVAGLIA CARDOSO, SILVIA REGINA; REIS, MARCELO DA SILVA; ZELANIS, ANDRE; SERRANO, SOLANGE M. T.; REINHOLD, VERNON. Structures of N-Glycans of Bothrops Venoms Revealed as Molecular Signatures that Contribute to Venom Phenotype in Viperid Snakes. MOLECULAR & CELLULAR PROTEOMICS, v. 17, n. 7, p. 1261-1284, . (13/07467-1, 13/14651-3, 13/13548-4, 14/12245-0)
OLIVEIRA, DANIELLE B. L.; DURIGON, GIULIANA S.; MENDES, ERICA A.; LADNER, JASON T.; ANDREATA-SANTOS, ROBERT; ARAUJO, DANIELLE B.; BOTOSSO, VIVIANE F.; PAOLA, NICHOLAS D.; NETO, DANIEL F. L.; CUNHA, MARIELTON P.; et al. Persistence and Intra-Host Genetic Evolution of Zika Virus Infection in Symptomatic Adults: A Special View in the Male Reproductive System. Viruses-Basel, v. 10, n. 11, . (14/16333-1, 14/03911-7, 14/17766-9, 13/26942-2, 16/20045-7, 16/08727-5, 14/27228-4, 15/25643-7, 13/07467-1, 16/08204-2, 16/03605-9)
CALDERANO, SIMONE GUEDES; DROSOPOULOS, WILLIAM C.; QUARESMA, MARINA MONACO; MARQUES, CATARINA A.; KOSIYATRAKUL, SETTAPONG; MCCULLOCH, RICHARD; SCHILDKRAUT, CARL L.; ELIAS, MARIA CAROLINA. Single molecule analysis of Trypanosoma brucei DNA replication dynamics. Nucleic Acids Research, v. 43, n. 5, p. 2655-2665, . (12/24554-2, 13/07467-1, 11/21570-4)
DIAS, MATHEUS H.; KITANO, EDUARDO S.; ZELANIS, ANDRE; IWAI, LEO K.. Proteomics and drug discovery in cancer. DRUG DISCOVERY TODAY, v. 21, n. 2, p. 264-277, . (13/07467-1, 12/20186-9, 14/06579-3, 11/11308-0)
LOPES-FERREIRA, MONICA; SOSA-ROSALES, INES; SILVA JUNIOR, PEDRO ISMAEL; CONCEICAO, KATIA; MALESKI, ADOLFO LUIS ALMEIDA; BALAN-LIMA, LETICIA; DISNER, GEONILDO RODRIGO; LIMA, CARLA. olecular Characterization and Functional Analysis of the Nattectin-like Toxin from the Venomous Fish Thalassophryne maculos. OXIN, v. 14, n. 1, . (13/07467-1)
ROSON, JULIANA NUNES; VITARELLI, MARCELA DE OLIVEIRA J.; COSTA-SILVA, HELLIDA MARINA; PEREIRA, KAMILLE SCHMITT; PIRES, DAVID DA SILVA; LOPES, LETICIA DE SOUSA; CORDEIRO, BARBARA; KRAUS, AMELIE; CRUZ, KARIN NAVARRO TOZZI; CALDERANO, SIMONE GUEDES; et al. 2B.V demarcates divergent strand-switch regions, some tDNA loci, and genome compartments in Trypanosoma cruzi and affects parasite differentiation and host cell invasio. PLOS PATHOGENS, v. 18, n. 2, . (18/15553-9, 16/50050-2, 17/06104-3, 19/04483-2, 19/16033-1, 13/07467-1, 19/19834-5)
BATISTA-FILHO, JOAO; FALCAO, MARIA ALICE PIMENTEL; MALESKI, ADOLFO LUIS ALMEIDA; SOARES, AMANDA BEATRIZ SILVA; BALAN-LIMA, LETICIA; DISNER, GEONILDO RODRIGO; LIMA, CARLA; LOPES-FERREIRA, MONICA. Early preclinical screening using zebrafish (Danio rerio) reveals the safety of the candidate anti-inflammatory therapeutic agent TnP. TOXICOLOGY REPORTS, v. 8, p. 13-22, . (13/07467-1)
A. LILLO; F. CARVAJAL-CAICONTE; W. VITAL; P. I. SILVA JUNIOR; E. J. PAREDES-GAMERO; M. ALVEAR; A. MIRANDA. Propriedades bioativas de extratos de folhas e frutos de Persea lingue Ness (Lauraceae). Brazilian Journal of Biology, v. 83, . (13/07467-1)
LONGHI, M. T.; SILVA, L. E.; PEREIRA, M.; MAGALHAES, M.; REINA, J.; VITORINO, F. N. L.; GUMBINER, B. M.; DA CUNHA, J. P. C.; CELLA, N.. PI3K-AKT, JAK2-STAT3 pathways and cell-cell contact regulate maspin subcellular localization. CELL COMMUNICATION AND SIGNALING, v. 19, n. 1, . (17/18344-9, 13/00815-4, 15/09309-0, 13/07467-1, 15/16384-8)
KATO, ELLEN EMI; PIMENTA, LUCIANA ARAUJO; SOARES DE ALMEIDA, MAIRA ESTANISLAU; ZAMBELLI, VANESSA OLZON; DOS SANTOS, MARINILCE FAGUNDES; SAMPAIO, SANDRA COCCUZZO. rotoxin Inhibits Endothelial Cell Functions in Two- and Three-dimensional Tumor Microenvironmen. FRONTIERS IN PHARMACOLOGY, v. 12, . (13/07467-1, 12/51241-5)
KISAKI, CAROLINA YUKIKO; ARCOS, STEPHANIE SANTOS SUEHIRO; MONTONI, FABIO; DA SILVA SANTOS, WELLINGTON; CALACINA, HAMIDA MACEDO; LIMA, ISMAEL FEITOSA; CAJADO-CARVALHO, DANIELA; FERRO, EMER SUAVINHO; NISHIYAMA-JR, MILTON YUTAKA; IWAI, LEO KEI. Bothrops Jararaca Snake Venom Modulates Key Cancer-Related Proteins in Breast Tumor Cell Lines. TOXINS, v. 13, n. 8, . (17/06496-9, 13/07467-1, 16/04000-3, 17/17943-6)
SANT'ANNA, MORENA BRAZIL; GIARDINI, ALINE C.; RIBEIRO, MARCIO A. C.; LOPES, FLAVIA S. R.; TEIXEIRA, NATHALIA B.; KIMURA, LOUISE F.; BUFALO, MICHELLE C.; RIBEIRO, ORLANDO G.; BORREGO, ANDREA; CABRERA, WAFA H. K.; et al. The Crotoxin:SBA-15 Complex Down-Regulates the Incidence and Intensity of Experimental Autoimmune Encephalomyelitis Through Peripheral and Central Actions. FRONTIERS IN IMMUNOLOGY, v. 11, . (17/17844-8, 15/01254-1, 14/19397-0, 13/07467-1)
MEGALE, ANGELA ALICE AMADEU; PORTARO, FERNANDA CALHETA; DA SILVA, WILMAR DIAS. Bitis arietans Snake Venom Induces an Inflammatory Response Which Is Partially Dependent on Lipid Mediators. TOXINS, v. 12, n. 9, . (13/07467-1)
CALDERANO, SIMONE GUEDES; NISHIYAMA JUNIOR, MILTON YUTAKA; MARINI, MARJORIE; NUNES, NATHAN DE OLIVEIRA; REIS, MARCELO DA SILVA; PATANE, JOSE SALVATORE LEISTER; DA SILVEIRA, JOSE FRANCO; DA CUNHA, JULIA PINHEIRO CHAGAS; ELIAS, MARIA CAROLINA. Identification of Novel Interspersed DNA Repetitive Elements in the Trypanosoma cruzi Genome Associated with the 3 ` UTRs of Surface Multigenic Families. GENES, v. 11, n. 10, . (13/07467-1, 16/50050-2)
SOUZA, GLAUCIA MENDES; VAN SLUYS, MARIE-ANNE; LEMBKE, CAROLINA GIMILIANI; LEE, HAYAN; MARGARIDO, GABRIEL RODRIGUES ALVES; HOTTA, CARLOS TAKESHI; GAIARSA, JONAS WEISSMANN; DINIZ, AUGUSTO LIMA; OLIVEIRA, MAURO DE MEDEIROS; FERREIRA, SAVIO DE SIQUEIRA; et al. Assembly of the 373k gene space of the polyploid sugarcane genome reveals reservoirs of functional diversity in the world's leading biomass crop. GIGASCIENCE, v. 8, n. 12, . (11/50761-2, 17/02270-6, 16/06917-1, 14/50921-8, 08/52074-0, 13/23048-9, 15/22993-7, 13/07467-1, 08/52146-0, 16/17545-8, 12/51062-3)
ESPINOZA-CULUPU, ABRAHAM; MENDES, ELIZABETH; VITORINO, HECTOR AGUILAR; DA SILVA JR, PEDRO ISMAEL; BORGES, MONAMARIS MARQUES. Mygalin: An Acylpolyamine With Bactericidal Activity. FRONTIERS IN MICROBIOLOGY, v. 10, . (13/11212-9, 13/07467-1)
SILVA DE FRANCA, FELIPE; VILLAS-BOAS, ISADORA MARIA; COGLIATI, BRUNO; WOODRUFF, TRENT M.; REIS, EDIMARA DA SILVA; LAMBRIS, JOHN D.; TAMBOURGI, DENISE V.. C5a-C5aR1 Axis Activation Drives Envenomation Immunopathology by the Snake Naja annulifera. FRONTIERS IN IMMUNOLOGY, v. 12, . (13/07467-1)
CEOLIN MARIANO, DOUGLAS OSCAR; DE OLIVEIRA, URSULA CASTRO; ZAHARENKO, ANDRE JUNQUEIRA; PIMENTA, DANIEL CARVALHO; RADIS-BAPTISTA, GANDHI; DE BRANDAO PRIETO-DA-SILVA, ALVARO ROSSAN. Bottom-Up Proteomic Analysis of Polypeptide Venom Components of the Giant Ant Dinoponera Quadriceps. TOXINS, v. 11, n. 8, . (13/07467-1)
ZELANIS, ANDRE; OLIVEIRA, ANA K.; PRUDOVA, ANNA; HUESGEN, PITTER F.; TASHIMA, ALEXANDRE K.; KIZHAKKEDATHU, JAYACHANDRAN; OVERALL, CHRISTOPHER M.; SERRANO, SOLANGE M. T.. Deep Profiling of the Cleavage Specificity and Human Substrates of Snake Venom Metalloprotease HF3 by Proteomic Identification of Cleavage Site Specificity (PICS) Using Proteome Derived Peptide Libraries and Terminal Amine Isotopic Labeling of Substrates (TAILS) N-Terminomics. JOURNAL OF PROTEOME RESEARCH, v. 18, n. 9, p. 3419-3428, . (13/07467-1, 11/23403-8, 11/08514-8, 10/17328-0)
ROBERTO TADASHI KODAMA; ALEXANDRE KAZUO KUNIYOSHI; CRISTIANE CASTILHO FERNANDES DA SILVA; DANIELA CAJADO-CARVALHO; BRUNO DUZZI; DOUGLAS CEOLIN MARIANO; DANIEL C. PIMENTA; RAFAEL BORGES; WILMAR DIAS DA SILVA; FERNANDA CALHETA VIEIRA PORTARO. A Kunitz-type peptide from Dendroaspis polylepis venom as a simultaneous inhibitor of serine and cysteine proteases. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 26, p. -, . (15/13124-5, 13/07467-1, 11/02061-1, 15/15364-3, 13/15344-7)
SILVA, JULIETE A. F.; BIANCARDI, MANOEL F.; STACH-MACHADO, DAGMAR R.; REIS, LEONARDO O.; SANT'ANNA, OSVALDO A.; CARVALHO, HERNANDES F.. The origin of prostate gland-secreted IgA and IgG. SCIENTIFIC REPORTS, v. 7, . (13/07467-1, 09/16150-6)
DE FARIAS, IASMIM BAPTISTA; DE MORAIS-ZANI, KAREN; SERINO-SILVA, CAROLINE; SANT'ANNA, SAVIO S.; DA ROCHA, MARISA M. T.; GREGO, KATHLEEN F.; ANDRADE-SILVA, DEBORA; SERRANO, SOLANGE M. T.; TANAKA-AZEVEDO, ANITA M.. Functional and proteomic comparison of Bothrops jararaca venom from captive specimens and the Brazilian Bothropic Reference Venom. JOURNAL OF PROTEOMICS, v. 174, p. 36-46, . (13/05357-4, 17/16908-2, 16/16935-7, 17/01890-0, 14/11108-0, 13/07467-1)
MENEZES, MILENE C.; KITANO, EDUARDO S.; BAUER, VERENA C.; OLIVEIRA, ANA K.; CARARO-LOPES, EDUARDO; NISHIYAMA, JR., MILTON Y.; ZELANIS, ANDRE; SERRANO, SOLANGE M. T.. Early response of C2C12 myotubes to a sub-cytotoxic dose of hemorrhagic metalloproteinase HF3 from Bothrops jararaca venom. JOURNAL OF PROTEOMICS, v. 198, p. 163-176, . (13/07467-1, 15/23691-4, 11/11308-0)
DA SILVA, MARCELO S.; CAYRES-SILVA, GUSTAVO R.; VITARELLI, MARCELA O.; MARIN, PAULA A.; HIRAIWA, PRISCILA M.; ARAUJO, CHRISTIANE B.; SCHOLL, BRUNO B.; AVILA, ANDREA R.; MCCULLOCH, RICHARD; REIS, MARCELO S.; et al. Transcription activity contributes to the firing of non-constitutive origins in African trypanosomes helping to maintain robustness in S-phase duration. SCIENTIFIC REPORTS, v. 9, . (15/10580-0, 17/07693-2, 17/18719-2, 16/17775-3, 14/24170-5, 16/50050-2, 13/07467-1, 14/13375-5)
LOPES, PRISCILA HESS; SQUAIELLA-BAPTISTAO, CARLA CRISTINA; MARQUES, MARIO OCTAVIO THA; TAMBOURGI, DENISE V.. Clinical aspects, diagnosis and management of Loxosceles spider envenomation: literature and case review. ARCHIVES OF TOXICOLOGY, v. 94, n. 5, . (13/07467-1, 15/17053-5)
LOPES, PRISCILA HESS; MURAKAMI, MARIO T.; PORTARO, V, FERNANDA C.; MESQUITA PASQUALOTO, KERLY FERNANDA; VAN DEN BERG, CARMEN; TAMBOURGI, V, DENISE. Targeting Loxosceles spider Sphingomyelinase D with small-molecule inhibitors as a potential therapeutic approach for loxoscelism. Journal of Enzyme Inhibition and Medicinal Chemistry, v. 34, n. 1, p. 310-321, . (13/07467-1, 08/57898-0, 15/17053-5)
LIBERATO, TARCISIO; FUKUSHIMA, ISABELLA; KITANO, EDUARDO S.; SERRANO, SOLANGE M. T.; CHAMMAS, ROGER; ZELANIS, ANDRE. Proteomic profiling of the proteolytic events in the secretome of the transformed phenotype of melanocyte-derived cells using Terminal Amine Isotopic Labeling of Substrates. JOURNAL OF PROTEOMICS, v. 192, p. 291-298, . (14/06579-3, 13/07467-1, 17/07897-7)
THOMAZINI, CAMILA MARTOS; SACHETTO, ANA TERESA AZEVEDO; DE ALBUQUERQUE, CYNTHIA ZACCANINI; DE MOURA MATTARAIA, VANIA GOMES; DE OLIVEIRA, ANA KARINA; SERRANO, SOLANGE MARIA DE TOLEDO; LEBRUN, IVO; BARBARO, KATIA CRISTINA; SANTORO, MARCELO LARAMI. Involvement of von Willebrand factor and botrocetin in the thrombocytopenia induced by Bothrops jararaca snake venom. PLoS Neglected Tropical Diseases, v. 15, n. 9, . (13/07467-1, 18/26015-8, 13/20239-8, 19/07618-6, 13/25177-0)
KIMURA, LOUISE F.; SANT'ANNA, MORENA B.; ANDRADE, SONIA A.; EBRAM, MATTEO C.; LIMA, CRISTIANE F. G.; CELANO, ROSA M. G.; VIEGAS, RUY F. M.; PICOLO, GISELE. COVID-19 induces proatherogenic alterations in moderate to severe non-comorbid patients: A single-center observational study. BLOOD CELLS MOLECULES AND DISEASES, v. 92, . (19/05882-8, 13/07467-1)
ANDRADE-SILVA, DEBORA; NISHIYAMA JR, MILTON Y.; STUGINSKI, DANIEL R.; ZELANIS, ANDRE; SERRANO, SOLANGE M. T.. The distinct N-terminomes of Bothrops jararaca newborn and adult venoms. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, v. 1869, n. 7, . (16/16935-7, 13/07467-1, 13/14651-3)
SEGURA-RAMIREZ, PAULA J.; DE GODOY, PEDRO MACHADO; AVINO, IVAN N.; SILVA JUNIOR, PEDRO I.. Encrypted antimicrobial peptides from proteins present in the plasma of the millipede Rhinocricus sp.. JOURNAL OF PROTEOMICS, v. 242, . (13/07467-1)
ALMEIDA, DIEGO DANTAS; VIALA, VINCENT LOUIS; NACHTIGALL, PEDRO GABRIEL; BROE, MICHAEL; GIBBS, H. LISLE; SERRANO, SOLANGE MARIA DE TOLEDO; MOURA-DA-SILVA, ANA MARIA; HO, PAULO LEE; NISHIYAMA-JR, MILTON YUTAKA; JUNQUEIRA-DE-AZEVEDO, INACIO L. M.. Tracking the recruitment and evolution of snake toxins using the evolutionary context provided by the Bothrops jararaca genome. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 118, n. 20, . (16/50127-5, 13/07467-1, 15/03509-7, 12/00177-5, 18/26520-4)
AOUNALLAH, HAJER; BENSAOUD, CHAIMA; M'GHIRBI, YOUMNA; FARIA, FERNANDA; CHMELAR, JINDRICH; KOTSYFAKIS, MICHAIL. Tick Salivary Compounds for Targeted Immunomodulatory Therapy. FRONTIERS IN IMMUNOLOGY, v. 11, . (13/07467-1)
HAUZMAN, EINAT; PIEROTTI, MICHELE E. R.; BHATTACHARYYA, NIHAR; TASHIRO, JULIANA H.; YOVANOVICH, CAROLA A. M.; CAMPOS, POLLYANNA F.; VENTURA, DORA F.; CHANG, BELINDA S. W.. imultaneous Expression of UV and Violet SWS1 Opsins Expands the Visual Palette in a Group of Freshwater Snake. Molecular Biology and Evolution, v. 38, n. 12, p. 5225-5240, . (18/11502-0, 14/26818-2, 18/13910-9, 14/25743-9, 18/09321-8, 13/07467-1, 15/14857-6)
AOUNALLAH, HAJER; FESSEL, MELISSA REGINA; GOLDFEDER, MAURICIO BARBUGIANI; CARVALHO, ENEAS; BENSAOUD, CHAIMA; CHUDZINSKI-TAVASSI, ANA MARISA; BOUATTOUR, ALI; M'GHIRBI, YOUMNA; FARIA, FERNANDA. Dromaserpin: A Novel Anti-Hemostatic Serpin, from the Salivary Glands of the Hard Tick Hyalomma dromedari. TOXINS, v. 13, n. 12, . (13/07467-1)
LOPES, PRISCILA HESS; VAN DEN BERG, CARMEN W.; TAMBOURGI, V, DENISE. Sphingomyelinases D From Loxosceles Spider Venoms and Cell Membranes: Action on Lipid Rafts and Activation of Endogenous Metalloproteinases. FRONTIERS IN PHARMACOLOGY, v. 11, . (13/07467-1, 15/17053-5)
MOREIRA, RAFAEL J.; CASTRO, ERIQUE; OLIVEIRA, TIAGO E.; BELCHIOR, THIAGO; PEIXOTO, ALBERT S.; CHAVES-FILHO, ADRIANO B.; MORENO, MAYARA F.; LIMA, JANAYNA D.; YOSHINAGA, MARCOS; MIYAMOTO, SAYURI; et al. Lipoatrophy-Associated Insulin Resistance and Hepatic Steatosis are Attenuated by Intake of Diet Rich in Omega 3 Fatty Acids. MOLECULAR NUTRITION & FOOD RESEARCH, v. 64, n. 7, . (16/04000-3, 17/17943-6, 13/07937-8, 15/19530-5, 14/06863-3, 18/15549-1, 13/07467-1)
BUENO, THAIS CAVENATTI; COLLACO, RITA DE CASSIA; CARDOSO, BIANCA APARECIDA; BREDARIOL, RAFAEL FUMACHI; ESCOBAR, MARILIA LEAL; CAJADO, ISABELA BUBENIK; GRACIA, MARTA; ANTUNES, EDSON; ZAMBELLI, VANESSA O.; PICOLO, GISELE; et al. Neurotoxicity of Olindias sambaquiensis and Chiropsalmus quadrumanus extracts in sympathetic nervous system. Toxicon, v. 199, p. 127-138, . (11/50242-5, 13/07467-1)
DISNER, GEONILDO R.; FALCAO, MARIA A. P.; LIMA, CARLA; LOPES-FERREIRA, MONICA. In Silico Target Prediction of Overexpressed microRNAs from LPS-Challenged Zebrafish (Danio rerio) Treated with the Novel Anti-Inflammatory Peptide TnP. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 22, n. 13, . (13/07467-1, 19/27677-7)
HAYASHIDA, PATRICIA YUMI; DA SILVA JUNIOR, PEDRO ISMAEL. Insights into Antimicrobial Peptides from Limacus flavus Mucus. Current Microbiology, v. 78, n. 8, p. 2970-2979, . (13/07467-1)
FRANCISQUINI, RODRIGO; BERTON, RAFAEL; SOARES, SANDRO GOMES; PESSOTTI, DAYELLE S.; CAMACHO, MAURICIO F.; ANDRADE-SILVA, DEBORA; BARCICK, UILLA; SERRANO, SOLANGE M. T.; CHAMMAS, ROGER; NASCIMENTO, MARIA C. V.; et al. Community-based network analyses reveal emerging connectivity patterns of protein-protein interactions in murine melanoma secretome. JOURNAL OF PROTEOMICS, v. 232, . (17/22330-3, 15/21660-4, 13/07375-0, 17/24185-0, 14/06579-3, 19/10817-0, 13/07467-1)
JMEL, MOHAMED AMINE; AOUNALLAH, HAJER; BENSAOUD, CHAIMA; MEKKI, IMEN; CHMELAR, JINDRICH; FARIA, FERNANDA; M'GHIRBI, YOUMNA; KOTSYFAKIS, MICHALIS. Insights into the Role of Tick Salivary Protease Inhibitors during Ectoparasite-Host Crosstalk. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 22, n. 2, . (13/07467-1)
LIMA, CARLA; FALCAO, MARIA ALICE PIMENTEL; ANDRADE-BARROS, ALINE INGRID; SENI-SILVA, ANA CAROLINA; GRUND, LIDIANE ZITO; BALOGH, ENIKO; CONCEICAO, KATIA; QUENIAUX, VALERIE F.; RYFFEL, BERNHARD; LOPES-FERREIRA, MONICA. Natterin an aerolysin-like fish toxin drives IL-1 beta-dependent neutrophilic inflammation mediated by caspase-1 and caspase-11 activated by the inflammasome sensor NLRP6. International Immunopharmacology, v. 91, . (18/17413-0, 19/10500-7, 13/07467-1)
DE LIMA, LOYZE P.; POUBEL, SALOE BISPO; YUAN, ZUO-FEI; ROSON, JULIANA NUNES; DE LUNA VITORINO, FRANCISCA NATHALIA; HOLETZ, FABIOLA BARBIERI; GARCIA, BENJAMIN A.; CHAGAS DA CUNHA, JULIA PINHEIRO. Improvements on the quantitative analysis of Trypanosoma cruzi histone post translational modifications: Study of changes in epigenetic marks through the parasite's metacyclogenesis and life cycle. JOURNAL OF PROTEOMICS, v. 225, . (18/21785-0, 17/06104-3, 18/14432-3, 18/15553-9, 13/07467-1, 17/18344-9)
BADARI, JULIANA CUOCO; DIAZ-ROA, ANDREA; TEIXEIRA ROCHA, MARISA MARIA; MENDONCA, RONALDO ZUCATELLI; SILVA JUNIOR, PEDRO ISMAEL DA. Patagonin-CRISP: Antimicrobial Activity and Source of Antimicrobial Molecules in Duvernoy's Gland Secretion (Philodryas patagoniensis Snake). FRONTIERS IN PHARMACOLOGY, v. 11, . (16/24867-1, 13/07467-1)
ASEGA, AMANDA F. .; MENEZES, MILENE C.; TREVISAN-SILVA, DILZA; CAJADO-CARVALHO, DANIELA; BERTHOLIM, LUCIANA; OLIVEIRA, ANA K.; ZELANIS, ANDRE; SERRANO, SOLANGE M. T.. Cleavage of proteoglycans, plasma proteins and the platelet-derived growth factor receptor in the hemorrhagic process induced by snake venom metalloproteinases. SCIENTIFIC REPORTS, v. 10, n. 1, . (17/00715-0, 10/00206-0, 17/19252-0, 10/17328-0, 11/08514-8, 13/07467-1)
PAVANI, RAPHAEL S.; DE LIMA, LOYZE P.; LIMA, ANDRE A.; FERNANDES, CARLOS A. H.; FRAGOSO, STENIO P.; CALDERANO, SIMONE G.; ELIAS, MARIA CAROLINA. Nuclear export of replication protein A in the nonreplicative infective forms of Trypanosoma cruzi. FEBS Letters, v. 594, n. 10, p. 1596-1607, . (16/50050-2, 14/02978-0, 18/14432-3, 18/21785-0, 13/07467-1)
LIMA, GUILHERME M.; MENEZES, MILENE C.; COSTA, IRIS M.; SERRANO, SOLANGE M. T.; MONTEIRO, GISELE. Development of a cell-free protein synthesis protocol to rapidly screen L-asparaginase proteoforms by enzymatic activity. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, v. 96, n. 9, p. 2659-2666, . (18/15041-8, 13/08617-7, 13/07467-1, 18/15104-0, 16/25896-5)
SILVA, NORTON FELIPE DOS SANTOS; WILLEMART, RODRIGO HIRATA; DA SILVA, JOSE ROBERTO MACHADO CUNHA; DA SILVA JUNIOR, PEDRO ISMAEL. rotein Components of the Arthrodial Membrane Gland in a Neotropical Harvestman (Arachnida, Opiliones. ACS OMEGA, . (13/07467-1, 20/05158-5)
CAETANO, LHIRI HANNA DE LUCCA; NISHIYAMA-JR, MILTON YUTAKA; TAVORA, BIANCA DE CARVALHO LINS FERNANDES; DE OLIVEIRA, URSULA CASTRO; JUNQUEIRA-DE-AZEVEDO, INACIO DE LOIOLA MEIRELLES; FAQUIM-MAURO, ELIANA L.; MAGALHAES, GERALDO SANTANA. Recombinant Production and Characterization of a New Toxin from Cryptops iheringi Centipede Venom Revealed by Proteome and Transcriptome Analysis. TOXINS, v. 13, n. 12, . (17/13812-4, 17/16999-8, 13/07467-1)
DE ARAUJO, CHRISTIANE BEZERRA; CHAGAS DA CUNHA, JULIA PINHEIRO; INADA, DAVI TOSHIO; DAMASCENO, JEZIEL; JERONIMO LIMA, ALEX RANIERI; HIRAIWA, PRISCILA; MARQUES, CATARINA; GONCALVES, EVONNILDO; NISHIYAMA-JUNIOR, MILTON YUTAKA; MCCULLOCH, RICHARD; et al. Replication origin location might contribute to genetic variability in Trypanosoma cruzi. BMC Genomics, v. 21, n. 1, . (13/07467-1, 14/24170-5, 16/50050-2, 14/13375-5)
DA SILVA, MARCELO S.; VITARELLI, MARCELA O.; SOUZA, BRUNO F.; ELIAS, MARIA CAROLINA. Comparative Analysis of the Minimum Number of Replication Origins in Trypanosomatids and Yeasts. GENES, v. 11, n. 5, . (13/07467-1, 14/24170-5, 16/50050-2, 17/18719-2, 17/07693-2)
MOURA-DA-SILVA, ANA MARIA; CONTRERAS-BERNAL, JORGE CARLOS; GIMENES, SARAH NATALIE CIRILO; FREITAS-DE-SOUSA, LUCIANA APARECIDA; PORTES-JUNIOR, JOSE ANTONIO; PEIXOTO, PEDRO DA SILVA; IWAI, LEO KEI; DE MOURA, VALERIA MOURAO; BISNETO, PEDRO FERREIRA; LACERDA, MARCUS; et al. The relationship between clinics and the venom of the causative Amazon pit viper (Bothrops atrox). PLoS Neglected Tropical Diseases, v. 14, n. 6, . (13/07467-1, 18/13108-8, 18/25749-8, 17/24546-3)
ESPINOZA-CULUPU, ABRAHAM; VAZQUEZ-RAMIREZ, RICARDO; FARFAN-LOPEZ, MARIELLA; MENDES, ELIZABETH; NOTOMI SATO, MARIA; DA SILVA JUNIOR, PEDRO ISMAEL; BORGES, MONAMARIS MARQUES. Acylpolyamine Mygalin as a TLR4 Antagonist Based on Molecular Docking and In Vitro Analyses. BIOMOLECULES, v. 10, n. 12, . (13/11212-9, 13/07467-1)
GLORIA MARIA DA SILVA; DANIEL HENRIQUE BERTO DE SOUZA; KAROLINE B. WAITMAN; MATTEO CELANO EBRAM; MELISSA R. FESSEL; IULIU CEZAR ZAINESCU; FERNANDA C. PORTARO; MONTSE HERAS; SONIA A. DE ANDRADE. Design, synthesis, and evaluation of Bothrops venom serine protease peptidic inhibitors. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 27, p. -, . (13/07467-1, 17/04321-7)
SILVA DE FRANCA, FELIPE; GABRILI, JOEL JOSE MEGALE; MATHIEU, LAURENCE; BURGHER, FRANCOIS; BLOMET, JOEL; TAMBOURGI, DENISE V.. Bothrops lanceolatus snake (Fer-de-lance) venom triggers inflammatory mediators' storm in human blood. ARCHIVES OF TOXICOLOGY, . (13/07467-1)
COSTA-SILVA, HELLIDA MARINA; RESENDE, BRUNO CARVALHO; UMAKI, ADRIANA CASTILHOS SOUZA; PRADO, WILLIAN; DA SILVA, MARCELO SANTOS; VIRGILIO, STELA; MACEDO, ANDREA MARA; PENA, SERGIO DANILO JUNHO; TAHARA, ERICH BIRELLI; TOSI, LUIZ RICARDO ORSINI; et al. DNA Topoisomerase 3 alpha Is Involved in Homologous Recombination Repair and Replication Stress Response in Trypanosoma cruzi. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, v. 9, . (14/24170-5, 18/14398-0, 13/07467-1, 16/50050-2)
HENRIQUE, CAMILA; PIMENTEL FALCAO, MARIA ALICE; PIMENTA, LUCIANA DE ARAUJO; ALMEIDA MALESKI, ADOLFO LUIS; LIMA, CARLA; MITSUNARI, THAIS; SAMPAIO, SANDRA COCCUZZO; LOPES-FERREIRA, MONICA; FONTES PIAZZA, ROXANE MARIA. Heat-Labile Toxin from Enterotoxigenic Escherichia coli Causes Systemic Impairment in Zebrafish Model. TOXINS, v. 13, n. 6, . (13/07467-1, 17/17213-8)
RICILUCA, KATIE C. T.; OLIVEIRA, URSULA C.; MENDONCA, RONALDO Z.; BOZELLI JUNIOR, JOSE C.; SCHREIER, SHIRLEY; DA SILVA JUNIOR, PEDRO I.. Rondonin: antimicrobial properties and mechanism of action. FEBS OPEN BIO, v. 11, n. 9, SI, . (13/07467-1)
BAGATELLI, FELIPE F. M.; DE LUNA VITORINO, FRANCISCA N.; DA CUNHA, JULIA P. C.; OLIVEIRA, CARLA C.. The ribosome assembly factor Nop53 has a structural role in the formation of nuclear pre-60S intermediates, affecting late maturation events. Nucleic Acids Research, v. 49, n. 12, p. 7053-7074, . (15/05776-2, 15/06477-9, 13/07467-1)
LIMA, CARLA; DISNER, GEONILDO RODRIGO; FALCAO, MARIA ALICE PIMENTEL; SENI-SILVA, ANA CAROLINA; MALESKI, ADOLFO LUIS ALMEIDA; SOUZA, MILENA MARCOLINO; REIS TONELLO, MAYARA CRISTINA; LOPES-FERREIRA, MONICA. The Natterin Proteins Diversity: A Review on Phylogeny, Structure, and Immune Function. TOXINS, v. 13, n. 8, . (13/07467-1, 19/27677-7, 19/02333-3)
ANDRADE-SILVA, DEBORA; ZELANIS, ANDRE; TRAVAGLIA-CARDOSO, SILVIA R.; NISHIYAMA, JR., MILTON Y.; SERRANO, SOLANGE M. T.. Venom Profiling of the Insular Species Bothrops alcatraz: Characterization of Proteome, Glycoproteome, and N-Terminome Using Terminal Amine Isotopic Labeling of Substrates. JOURNAL OF PROTEOME RESEARCH, v. 20, n. 2, p. 1341-1358, . (13/13548-4, 16/16935-7, 13/07467-1, 13/14651-3)
DOUGLAS O. MARIANO; JULIANA M. SCIANI; MARTA M. ANTONIAZZI; CARLOS JARED; KATIA CONCEIÇÃO; DANIEL C. PIMENTA. Quantity - but not diversity - of secreted peptides and proteins increases with age in the tree frog Pithecopus nordestinus. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 27, p. -, . (13/07467-1)
ARRUDA, GIAN LUCAS M.; VIGERELLI, HUGO; BUFALO, MICHELLE C.; LONGATO, GIOVANNA B.; VELOSO, RODINEI V.; ZAMBELLI, VANESSA O.; PICOLO, GISELE; CURY, YARA; MORANDINI, ANDRE C.; MARQUES, ANTONIO CARLOS; et al. Box Jellyfish (Cnidaria, Cubozoa) Extract Increases Neuron's Connection: A Possible Neuroprotector Effect. BIOMED RESEARCH INTERNATIONAL, v. 2021, . (15/21007-9, 15/50040-4, 16/06137-6, 19/19929-6, 13/07467-1, 11/50242-5)
ANDRADE-TOMAZ, MARINA; DE SOUZA, IZADORA; RIBEIRO REILY ROCHA, CLARISSA; RODRIGUES GOMES, LUCIANA. The Role of Chaperone-Mediated Autophagy in Cell Cycle Control and Its Implications in Cancer. CELLS, v. 9, n. 9, . (13/07467-1, 19/21745-0, 19/19435-3)
MONTONI, FABIO; ANDREOTTI, DIANA ZUKAS; DOS SANTOS EICHLER, ROSANGELA APARECIDA; SANTOS, WELLINGTON DA SILVA; KISAKI, CAROLINA YUKIKO; SUEHIRO ARCOS, STEPHANIE SANTOS; LIMA, ISMAEL FEITOSA; MALTAURO SOARES, MAGNA APARECIDA; NISHIYAMA-JR, MILTON YUTAKA; NAVA-RODRIGUES, DANIEL; et al. The impact of rattlesnake venom on mice cerebellum proteomics points to synaptic inhibition and tissue damage. JOURNAL OF PROTEOMICS, v. 221, . (17/17943-6, 13/07467-1, 16/04000-3, 15/50040-4, 17/06496-9)
BENSAOUD, CHAIMA; AOUNALLAH, HAJER; SCIANI, JULIANA MOZER; FARIA, FERNANDA; CHUDZINSKI-TAVASSI, ANA MARISA; BOUATTOUR, ALI; M'GHIRBI, YOUMNA. Proteomic informed by transcriptomic for salivary glands components of the camel tick Hyalomma dromedarii. BMC Genomics, v. 20, n. 1, . (13/07467-1)
DA SILVA, MARCELO SANTOS; HOVEL-MINER, GALADRIEL A.; BRIGGS, EMMA M.; ELIAS, MARIA CAROLINA; MCCULLOCH, RICHARD. Evaluation of mechanisms that may generate DNA lesions triggering antigenic variation in African trypanosomes. PLOS PATHOGENS, v. 14, n. 11, . (14/24170-5, 13/07467-1, 16/50050-2, 17/18719-2)
DE FREITAS, BARBARA GUIMARAES; PEREIRA, LEANDRO MARCIO; SANTA-CECILIA, FLAVIA VIANNA; HOSCH, NATALIA GABRIELE; PICOLO, GISELE; CURY, YARA; ZAMBELLI, VANESSA O.. Mitogen-Activated Protein Kinase Signaling Mediates Morphine Induced-Delayed Hyperalgesia. FRONTIERS IN NEUROSCIENCE, v. 13, . (13/07467-1, 08/57898-0)
CHAPARRO-AGUIRRE, ELISA; SEGURA-RAMIREZ, PAULA J.; ALVES, FLAVIO L.; RISKE, KARIN A.; MIRANDA, ANTONIO; SILVA JUNIOR, I, PEDRO. Antimicrobial activity and mechanism of action of a novel peptide present in the ecdysis process of centipede Scolopendra subspinipes subspinipes. SCIENTIFIC REPORTS, v. 9, . (13/07467-1)
RICILUCA, K. C. T.; BORGES, A. C.; MELLO, J. F. R.; DE OLIVEIRA, U. C.; SERDAN, D. C.; FLOREZ-ARIZA, A.; CHAPARRO, E.; NISHIYAMA-JR, M. Y.; CASSAGO, A.; JUNQUEIRA-DE-AZEVEDO, I. L. M.; et al. Myriapod haemocyanin: the first three-dimensional reconstruction of Scolopendra subspinipes and preliminary structural analysis of S. viridicornis. OPEN BIOLOGY, v. 10, n. 4, . (13/07467-1, 17/15340-2)
SOARES-SCHANOSKI, ALESSANDRA; BAPTISTA CRUZ, NATALIA; DE CASTRO-JORGE, LUIZA ANTUNES; HOMEM DE CARVALHO, RENAN VILLANOVA; DOS SANTOS, CLIOMAR ALVES; DA ROS, NANCY; OLIVEIRA, URSULA; COSTA, DANUZA DUARTE; SIMOES DOS SANTOS, CECILIA LUIZA; CUNHA, MARIELTON DOS PASSOS; et al. Systems analysis of subjects acutely infected with the Chikungunya virus. PLOS PATHOGENS, v. 15, n. 6, . (12/19278-6, 13/08216-2, 15/25055-8, 17/50137-3, 13/07467-1, 16/08204-2)
TEIXEIRA, SAMUEL COTA; LOPES, DAIANA SILVA; DA SILVA, MARCELO SANTOS; CORDERO DA LUZ, FELIPE ANDRES; CIRILO GIMENES, SARAH NATALIE; BORGES, BRUNA CRISTINA; DA SILVA, ALINE ALVES; MARTINS, FLAVIA ALVES; DOS SANTOS, MARIUS ALVES; TEIXEIRA, THAISE LARA; et al. Pentachloropseudilin Impairs Angiogenesis by Disrupting the Actin Cytoskeleton, Integrin Trafficking and the Cell Cycle. CHEMBIOCHEM, v. 20, n. 18, . (13/07467-1, 14/24170-5)
LIBERATO, TARCISIO; PESSOTTI, DAYELLE S.; FUKUSHIMA, ISABELLA; KITANO, EDUARDO S.; SERRANO, SOLANGE M. T.; ZELANIS, ANDRE. Signatures of protein expression revealed by secretome analyses of cancer associated fibroblasts and melanoma cell lines. JOURNAL OF PROTEOMICS, v. 174, p. 1-8, . (13/07467-1, 17/07897-7, 14/06579-3)
ZELANIS, ANDRE; SILVA, DEBORA A.; KITANO, EDUARDO S.; LIBERATO, TARCISIO; FUKUSHIMA, ISABELLA; SERRANO, SOLANGE M. T.; TASHIMA, ALEXANDRE K.. A first step towards building spectral libraries as complementary tools for snake venom proteome/peptidome studies. Comparative Biochemistry and Physiology D-Genomics & Proteomics, v. 31, . (13/14651-3, 14/06579-3, 17/20106-9, 13/07467-1, 17/07897-7, 13/13548-4)
SEGURA-RAMIREZ, PAULA J.; SILVA JUNIOR, PEDRO I.. Loxosceles gaucho Spider Venom: An Untapped Source of Antimicrobial Agents. TOXINS, v. 10, n. 12, . (13/07467-1)
EMILIO TAVERNELLI, LUIS; MOTTA, MARIA CRISTINA M.; SILVA GONCALVES, CAMILA; DA SILVA, MARCELO SANTOS; ELIAS, MARIA CAROLINA; LUCIA ALONSO, VICTORIA; SERRA, ESTEBAN; CRIBB, PAMELA. Overexpression of Trypanosoma cruzi High Mobility Group B protein (TcHMGB) alters the nuclear structure, impairs cytokinesis and reduces the parasite infectivity. SCIENTIFIC REPORTS, v. 9, . (14/24170-5, 13/07467-1)
PIDDE, GISELLE; NISHIYAMA, MILTON Y.; DE OLIVEIRA, URSULA CASTRO; VILLAS-BOAS, ISADORA M.; PAES-LEME, ADRIANA F.; JUNQUEIRA-DE-AZEVEDO, INACIO L.; MARQUES-PORTO, RAFAEL; SQUAIELLA-BAPTISTAO, CARLA C.; TAMBOURGI, DENISE V.. Integrative multiomics analysis of Premolis semirufa caterpillar venom in the search for molecules leading to a joint disease. SCIENTIFIC REPORTS, v. 11, n. 1, . (13/07467-1, 15/50040-4)
DE MENEZES TORRES, KATIA ANDREA; ROLIM ROSA LIMA, SONIA MARIA; BRANDAO TORRES, LUCE MARIA; GAMBERINI, MARIA THEREZA; DA SILVA JUNIOR, PEDRO ISMAEL. Garlic: An Alternative Treatment for Group B Streptococcus. MICROBIOLOGY SPECTRUM, v. 9, n. 3, . (13/07467-1)
GONCALVES, MARIANA TORRENTE; SQUAIELLA-BAPTISTAO, CARLA CRISTINA; PIDDE, GISELLE; LOPES, PRISCILA HESS; DA SILVA NUNES, ISEU; TAMBOURGI, DENISE V.. P-MAPA, a Fungi-Derived Immunomodulatory Compound, Induces a Proinflammatory Response in a Human Whole Blood Model. Mediators of Inflammation, v. 2020, . (13/07467-1, 12/05306-8)
NOVAES, TATIANE FERNANDES; JORDAO, MAISA CAMILLO; BONACINA, CARLOS FELIPE; VERONEZI, ANDRE OSWALDO; RODRIGUES DE ARAUJO, CARLOS ARIEL; OLEGARIO, ISABEL CRISTINA; DE OLIVEIRA, DANIELE BOINA; USHAKOVA, VERANIKA; BIRBRAIR, ALEXANDER; PALACIO, DANIELLE DA COSTA; et al. COVID-19 pandemic impact on dentists in Latin America's epicenter: SAo-Paulo, Brazil. PLoS One, v. 16, n. 8, . (13/07467-1, 17/17943-6)
LUND, PEDER J.; LOPES, MARIANA; SIDOLI, SIMONE; CORADIN, MARIEL; DE LUNA VITORINO, FRANCISCA NATHALIA; CHAGAS DA CUNHA, JULIA PINHEIRO; GARCIA, BENJAMIN A.. FGF-2 induces a failure of cell cycle progression in cells harboring amplified K-Ras, revealing new insights into oncogene-induced senescence. MOLECULAR OMICS, v. 17, n. 5, p. 725-739, . (16/24881-4, 15/04867-4, 13/07467-1, 17/15835-1, 18/15553-9, 11/22619-7, 17/18344-9)
TEIXEIRA, N. B.; SANT'ANNA, M. B.; GIARDINI, A. C.; ARAUJO, L. P.; FONSECA, L. A.; BASSO, A. S.; CURY, Y.; PICOLO, G.. Crotoxin down-modulates pro-inflammatory cells and alleviates pain on the MOG(35-55)-induced experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. BRAIN BEHAVIOR AND IMMUNITY, v. 84, p. 253-268, . (11/17974-2, 10/12903-7, 13/07467-1)
ESTRELA, GUSTAVO; GUBITOSO, MARCO DIMAS; FERREIRA, CARLOS EDUARDO; BARRERA, JUNIOR; REIS, MARCELO S.. An Efficient, Parallelized Algorithm for Optimal Conditional Entropy-Based Feature Selection. Entropy, v. 22, n. 4, . (16/25959-7, 13/07467-1, 15/01587-0)
ALMEIDA, MICHELLE TEIXEIRA DE; FREITAS-DE-SOUSA, LUCIANA APARECIDA; COLOMBINI, MONICA; GIMENES, SARAH N. C.; KITANO, EDUARDO S.; FAQUIM-MAURO, ELIANA L.; SERRANO, SOLANGE M. T.; MOURA-DA-SILVA, ANA MARIA. Inflammatory Reaction Induced by Two Metalloproteinases Isolated from Bothrops atrox Venom and by Fragments Generated from the Hydrolysis of Basement Membrane Components. TOXINS, v. 12, n. 2, . (13/07467-1, 16/50127-5, 14/26058-8)
LIMA DINIZ, LAURA CRISTINA; SILVA JUNIOR, PEDRO ISMAEL. Hemoglobin Reassembly of Antimicrobial Fragments from the Midgut of Triatoma infestans. BIOMOLECULES, v. 10, n. 2, . (13/07467-1)
FALCAO, MARIA ALICE PIMENTEL; WALKER, CRISTIANI ISABEL BANDERO; DISNER, GEONILDO RODRIGO; BATISTA-FILHO, JOAO; SOARES, AMANDA BEATRIZ SILVA; BALAN-LIMA, LETICIA; LIMA, CARLA; LOPES-FERREIRA, MONICA. nockdown of miR-26a in zebrafish leads to impairment of the anti-inflammatory function of TnP in the control of neutrophili. FISH & SHELLFISH IMMUNOLOGY, v. 114, p. 301-310, . (13/07467-1)
NAVARRO, MARINA V.; CHAVES, ALISON F. A.; CASTILHO, DANIELE G.; CASULA, ISIS; CALADO, JULIANA C. P.; CONCEICAO, PALLOMA M.; IWAI, LEO K.; DE CASTRO, BEATRIZ F.; BATISTA, WAGNER L.. Effect of Nitrosative Stress on theS-Nitroso-Proteome ofParacoccidioides brasiliensis. FRONTIERS IN MICROBIOLOGY, v. 11, . (17/04592-0, 13/07467-1, 16/04000-3, 15/09654-9, 17/17943-6)
DA SILVA, MARCELO SANTOS; LOPES, PRISCILA HESS; ELIAS, MARIA CAROLINA; TAMBOURGI, V, DENISE. Cytotoxic and genotoxic effects on human keratinocytes triggered by sphingomyelinase D from Loxosceles venom. ARCHIVES OF TOXICOLOGY, v. 94, n. 10, . (15/17053-5, 13/07467-1, 14/24170-5)
LOPES, PRISCILA HESS; FUKUSHIMA, CAROLINE SAYURI; SHOJI, ROSANA; BERTANI, ROGERIO; TAMBOURGI, V, DENISE. Sphingomyelinase D Activity in Sicarius tropicus Venom: Toxic Potential and Clues to the Evolution of SMases D in the Sicariidae Family. TOXINS, v. 13, n. 4, . (15/17053-5, 13/07467-1)
OLIVEIRA, DOUGLAS SOUZA; DE SOUZA, JEAN GABRIEL; ALVAREZ-FLORES, MIRYAM PAOLA; CUNEGUNDES, PRISCILA S.; DEOCESANO-PEREIRA, CARLOS; LOBBA, ALINE MAIA; GOMES, RENATA N.; CHUDZINSKI-TAVASSI, ANA MARISA. Lonomia obliqua Venom Induces NF-kappa B Activation and a Pro-Inflammatory Profile in THP-1-Derived Macrophage. TOXINS, v. 13, n. 7, . (15/50040-4, 13/07467-1)
SILVA, G. M.; BERTO, D. H.; LIMA, C. A.; WAITMAN, K. B.; LIMA, C. F. G.; PREZOTO, B. C.; VIEIRA, M. L.; ROCHA, M. M. T.; GONCALVES, L. R. C.; ANDRADE, S. A.. Synergistic effect of serine protease inhibitors and a bothropic antivenom in reducing local hemorrhage and coagulopathy caused by Bothrops jararaca venom. Toxicon, v. 199, p. 87-93, . (17/00236-5, 13/07467-1, 17/04321-7)
BAYONA-SERRANO, JUAN DAVID; VIALA, VINCENT LOUIS; RAUTSAW, RHETT M.; SCHRAMER, TRISTAN D.; BARROS-CARVALHO, GESIELE A.; NISHIYAMA, JR., MILTON YUTAKA; FREITAS-DE-SOUSA, LUCIANA A.; MOURA-DA-SILVA, ANA MARIA; PARKINSON, CHRISTOPHER L.; GRAZZIOTIN, FELIPE GOBBI; et al. Replacement and Parallel Simplification of Nonhomologous Proteinases Maintain Venom Phenotypes in Rear-Fanged Snakes. Molecular Biology and Evolution, v. 37, n. 12, p. 3563-3575, . (13/07467-1, 16/50127-5, 17/24498-9, 17/24546-3)
NACHTIGALL, PEDRO G.; GRAZZIOTIN, FELIPE G.; JUNQUEIRA-DE-AZEVEDO, INACIO L. M.. MITGARD: an automated pipeline for mitochondrial genome assembly in eukaryotic species using RNA-seq data. BRIEFINGS IN BIOINFORMATICS, v. 22, n. 5, . (13/07467-1, 16/50127-5, 18/26520-4)
KIMURA, LOUISE FAGGIONATO; SANT'ANNA, MORENA BRAZIL; ZAMBELLI, VANESSA OLZON; GIARDINI, ALINE CAROLINA; SILVA JARED, SIMONE GONCALVES; ANTONIAZZI, MARTA MARIA; DE MOURA MATTARAIA, VANIA GOMES; PAGANO, ROSANA LIMA; PICOLO, GISELE. Early exposure to environmental enrichment protects male rats against neuropathic pain development after nerve injury. Experimental Neurology, v. 332, . (13/07467-1, 08/57898-0, 13/20795-8)
LICHTENSTEIN, FLAVIO; IQBAL, ASIF; ALVES DE LIMA WILL, SONIA ELISABETE; BOSCH, ROSEMARY VIOLA; DEOCESANO-PEREIRA, CARLOS; GOLDFEDER, MAURICIO BARBUGIANI; CHAMMAS, ROGER; MADUREIRA TRUFEN, CARLOS EDUARDO; PEREIRA MORAIS, KATIA LUCIANO; DE SOUZA, JEAN GABRIEL; et al. Modulation of stress and immune response by Amblyomin-X results in tumor cell death in a horse melanoma model. SCIENTIFIC REPORTS, v. 10, n. 1, . (16/13588-4, 13/07467-1, 15/50040-4, 17/02052-9)
SCHMIDT, MARIANA COSTA BRAGA; MORAIS, KATIA L. P.; DE ALMEIDA, MAIRA ESTANISLAU SOARES; IQBAL, ASIF; GOLDFEDER, MAURICIO BARBUGIANI; CHUDZINSKI-TAVASSI, ANA MARISA. Amblyomin-X, a recombinant Kunitz-type inhibitor, regulates cell adhesion and migration of human tumor cells. CELL ADHESION & MIGRATION, v. 14, n. 1, p. 129-138, . (13/07467-1, 14/24512-3, 15/50040-4)
DO NASCIMENTO, SORAIA MARIA; DE OLIVEIRA, URSULA CASTRO; NISHIYAMA-JR, MILTON YUTAKA; TASHIMA, ALEXANDRE KEIJI; DA SILVA JUNIOR, PEDRO ISMAEL. Presence of a neprilysin on Avicularia juruensis (Mygalomorphae: Theraphosidae) venom. Toxin Reviews, . (13/07467-1)
LIMA, ALEX R. J.; DE ARAUJO, CHRISTIANE B.; BISPO, SALOE; PATANE, JOSE; SILBER, ARIEL M.; ELIAS, M. CAROLINA; DA CUNHA, JULIA P. C.. Nucleosome landscape reflects phenotypic differences in Trypanosoma cruzi life forms. PLOS PATHOGENS, v. 17, n. 1, . (18/15553-9, 19/19690-3, 18/14432-3, 16/50050-2, 13/07467-1)
LOPES, PRISCILA HESS; FUKUSHIMA, CAROLINE SAYURI; SHOJI, ROSANA; BERTANI, ROGERIO; TAMBOURGI, V, DENISE. Searching for the toxic potential of Loxosceles amazonica and Loxosceles willianilsoni spiders' venoms. Toxicon, v. 191, p. 1-8, . (15/17053-5, 13/07467-1)
CARARO-LOPES, EDUARDO; DIAS, MATHEUS H.; DA SILVA, MARCELO S.; ZEIDLER, JULIANNA D.; VESSONI, ALEXANDRE T.; REIS, MARCELO S.; BOCCARDO, ENRIQUE; ARMELIN, HUGO A.. Autophagy buffers Ras-induced genotoxic stress enabling malignant transformation in keratinocytes primed by human papillomavirus. CELL DEATH & DISEASE, v. 12, n. 2, . (13/07467-1)
BERTHOLIM, LUCIANA; CHAVES, ALISON F. A.; OLIVEIRA, ANA K.; MENEZES, MILENE C.; ASEGA, AMANDA F.; TASHIMA, ALEXANDRE K.; ZELANIS, ANDRE; SERRANO, SOLANGE M. T.. Systemic Effects of Hemorrhagic Snake Venom Metalloproteinases: Untargeted Peptidomics to Explore the Pathodegradome of Plasma Proteins. TOXINS, v. 13, n. 11, . (11/08514-8, 20/12317-2, 11/16623-1, 13/07467-1)
MYAMOTO, D. T.; PIDDE-QUEIROZ, G.; PEDROSO, A.; GONCALVES-DE-ANDRADE, R. M.; VAN DEN SERG, C. W.; TAMBOURGI, D. V.. Characterization of the gene encoding component C3 of the complement system from the spider Loxosceles laeta venom glands: Phylogenetic implications. Immunobiology, v. 221, n. 9, p. 953-963, . (13/07467-1)
SCARAMUZZI, KARINA; TANAKA, GABRIELA D.; MARIANO NETO, FRANCISCO; GARCIA, PAULO R. A. F.; GABRILI, JOEL J. M.; OLIVEIRA, DENISE C. A.; TAMBOURGI, DENISE V.; MUSSALEM, JULIANA S.; PAIXAO-CAVALCANTE, DANIELLE; D'AZEREDO ORLANDO, MARCOS T.; et al. Nanostructured SBA-15 silica: An effective protective vehicle to oral hepatitis B vaccine immunization. Nanomedicine-Nanotechnology Biology and Medicine, v. 12, n. 8, p. 2241-2250, . (13/07467-1)
LEANDRO DE JESUS, TERESA CRISTINA; CALDERANO, SIMONE GUEDES; DE LUNA VITORINO, FRANCISCA NATHALIA; LLANOS, RICARDO PARIONA; LOPES, MARIANA DE CAMARGO; DE ARAUJO, CHRISTIANE BEZERRA; THIEMANN, OTAVIO HENRIQUE; REIS, MARCELO DA SILVA; ELIAS, MARIA CAROLINA; CHAGAS DA CUNHA, JULIA PINHEIRO. Quantitative Proteomic Analysis of Replicative and Nonreplicative Forms Reveals Important Insights into Chromatin Biology of Trypanosoma cruzi. MOLECULAR & CELLULAR PROTEOMICS, v. 16, n. 1, p. 23-38, . (13/07467-1, 11/22619-7)
ROSA SAYEGH, RAPHAEL SANTA; CORREIA BATISTA, ISABEL DE FATIMA; DE MELO, ROBSON LOPES; RISKE, KARIN A.; DAFFRE, SIRLEI; MONTICH, GUILLERMO; DA SILVA JUNIOR, PEDRO ISMAEL. Longipin: An Amyloid Antimicrobial Peptide from the Harvestman Acutisoma longipes (Arachnida: Opiliones) with Preferential Affinity for Anionic Vesicles. PLoS One, v. 11, n. 12, . (13/07467-1)
KOMEGAE, EVILIN NANAME; MATOZO SOUZA, TAIS APARECIDA; GRUND, LIDIANE ZITO; LIMA, CARLA; LOPES-FERREIRA, MONICA. Multiple functional therapeutic effects of TnP: A small stable synthetic peptide derived from fish venom in a mouse model of multiple sclerosis. PLoS One, v. 12, n. 2, . (98/14307-9, 13/07467-1)
CHUDZINSKI-TAVASSI, ANA MARISA; MORAIS, KATIA L. P.; FERNANDES PACHECO, MARIO THIEGO; MESQUITA PASQUALOTO, KERLY FERNANDA; DE SOUZA, JEAN GABRIEL. Tick salivary gland as potential natural source for the discovery of promising antitumor drug candidates. BIOMEDICINE & PHARMACOTHERAPY, v. 77, p. 14-19, . (10/07958-7, 98/14307-9, 11/05969-4, 13/07467-1)
MYAMOTO, DANIELA TIEMI; PIDDE-QUEIROZ, GISELLE; GONCALVES-DE-ANDRADE, RUTE MARIA; PEDROSO, AURELIO; VAN DEN BERG, CARMEN W.; TAMBOURGI, DENISE V.. Characterization of a Gene Coding for the Complement System Component FB from Loxosceles laeta Spider Venom Glands. PLoS One, v. 11, n. 1, . (13/07467-1)
MENEZES, MILENE C.; IMBERT, LIONEL; KITANO, EDUARDO S.; VERNET, THIERRY; SERRANO, SOLANGE M. T.. Recombinant expression of the precursor of the hemorrhagic metalloproteinase HF3 and its non-catalytic domains using a cell-free synthesis system. Amino Acids, v. 48, n. 9, p. 2205-2214, . (13/07467-1)
SILVA, THAIOMARA A.; SMUCZEK, BASILIO; VALADAO, IURI C.; DZIK, LUCIANA M.; IGLESIA, REBECA P.; CRUZ, MARIO C.; ZELANIS, ANDRE; DE SIQUEIRA, ADRIANE S.; SERRANO, SOLANGE M. T.; GOLDBERG, GARY S.; et al. AHNAK enables mammary carcinoma cells to produce extracellular vesicles that increase neighboring fibroblast cell motility. ONCOTARGET, v. 7, n. 31, p. 49998-50016, . (13/07467-1, 10/07699-1, 15/00544-6, 11/09472-7)
LIBERATO, TARCISIO; PAOLO TRONCONE, LANFRANCO RANIERI; YAMASHIRO, EDSON T.; SERRANO, SOLANGE M. T.; ZELANIS, ANDRE. High-resolution proteomic profiling of spider venom: expanding the toxin diversity of Phoneutria nigriventer venom. Amino Acids, v. 48, n. 3, p. 901-906, . (13/07467-1, 11/08514-8)
CALDERANO, SIMONE; GODOY, PATRICIA; SOARES, DAIANE; SANT'ANNA, OSVALDO AUGUSTO; SCHENKMAN, SERGIO; ELIAS, M. CAROLINA. ORC1/CDC6 and MCM7 distinct associate with chromatin through Trypanosoma cruzi life cycle. Molecular and Biochemical Parasitology, v. 193, n. 2, p. 110-113, . (13/07467-1)
PACHECO, MARIO T. F.; BERRA, CAROLINA M.; MORAIS, KATIA L. P.; SCIANI, JULIANA M.; BRANCO, VANIA G.; BOSCH, ROSEMARY V.; CHUDZINSKI-TAVASSI, ANA M.. Dynein Function and Protein Clearance Changes in Tumor Cells Induced by a Kunitz-Type Molecule, Amblyomin-X. PLoS One, v. 9, n. 12, . (13/07467-1, 98/14307-9, 11/05969-4)
PEDROSO, AURELIO; MATIOLI, SERGIO RUSSO; MURAKAMI, MARIO TYAGO; PIDDE-QUEIROZ, GISELLE; TAMBOURGI, DENISE V.. Adaptive evolution in the toxicity of a spider's venom enzymes. BMC Evolutionary Biology, v. 15, . (13/07467-1)
SANTORO, MARCELO LARAMI; DO CARMO, THAIS; LOPES CUNHA, BRUNA HELOISA; ALVES, ANDRE FONSECA; ZELANIS, ANDRE; DE TOLEDO SERRANO, SOLANGE MARIA; GREGO, KATHLEEN FERNANDES; SANT'ANNA, SAVIO STEFANINI; BARBARO, KATIA CRISTINA; FERNANDES, WILSON. Ontogenetic Variation in Biological Activities of Venoms from Hybrids between Bothrops erythromelas and Bothrops neuwiedi Snakes. PLoS One, v. 10, n. 12, . (08/02996-8, 10/08162-1, 13/13548-4, 09/15413-3, 13/25177-0, 13/07467-1)
BALDON, ESTEVAM JOSE; MARENGO, ELIANA BLINI; DE FRANCO, MARCELO; STAROBINAS, NANCY; BUENO, VALQUIRIA; SANT'ANNA, OSVALDO AUGUSTO. Mycobacterium leprae Hsp65 administration reduces the lifespan of aged high antibody producer mice. IMMUNITY & AGEING, v. 11, . (13/07467-1)
CHAPARRO, E.; DA SILVA JUNIOR, P. I.. Lacrain: the first antimicrobial peptide from the body extract of the Brazilian centipede Scolopendra viridicornis. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, v. 48, n. 3, p. 277-285, . (13/07467-1)
PAVANI, RAPHAEL SOUZA; DA SILVA, MARCELO SANTOS; HENRIQUE FERNANDES, CARLOS ALEXANDRE; MORINI, FLAVIA SOUZA; ARAUJO, CHRISTIANE BEZERRA; DE MATTOS FONTES, MARCOS ROBERTO; SANT'ANNA, OSVALDO AUGUSTO; MACHADO, CARLOS RENATO; CANO, MARIA ISABEL; FRAGOSO, STENIO PERDIGAO; et al. Replication Protein A Presents Canonical Functions and Is Also Involved in the Differentiation Capacity of Trypanosoma cruzi. PLoS Neglected Tropical Diseases, v. 10, n. 12, . (14/13375-5, 14/24170-5, 13/17864-8, 14/02978-0, 13/07467-1, 15/10580-0)
ZAMBELLI, VANESSA O.; GROSS, ERIC R.; CHEN, CHE-HONG; GUTIERREZ, VANESSA P.; CURY, YARA; MOCHLY-ROSEN, DARIA. Aldehyde dehydrogenase-2 regulates nociception in rodent models of acute inflammatory pain. Science Translational Medicine, v. 6, n. 251, . (13/07467-1, 11/08873-8, 12/05035-4)
ZELANIS, ANDRE; HUESGEN, PITTER F.; OLIVEIRA, ANA KARINA; TASHIMA, ALEXANDRE K.; SERRANO, SOLANGE M. T.; OVERALL, CHRISTOPHER M.. Snake venom serine proteinases specificity mapping by proteomic identification of cleavage sites. JOURNAL OF PROTEOMICS, v. 113, p. 260-267, . (13/07467-1, 11/08514-8, 10/17328-0, 11/23403-8)
ANDRADE, GABRIELLE R.; NEW, ROGER R. C.; SANT'ANNA, OSVALDO A.; WILLIAMS, NEIL A.; ALVES, ROSELY C. B.; PIMENTA, DANIEL C.; VIGERELLI, HUGO; MELO, BRUNA S.; ROCHA, LETICIA B.; PIAZZA, ROXANE M. F.; et al. A universal polysaccharide conjugated vaccine against O111 E. coli. HUMAN VACCINES & IMMUNOTHERAPEUTICS, v. 10, n. 10, p. 2864-2874, . (13/07467-1, 12/11325-5)
DE SOUZA, JEAN GABRIEL; MORAIS, KATIA L. P.; ANGLES-CANO, EDUARDO; BOUFLEUR, PAMELA; DE MELLO, EVANDRO SOBROZA; MARIA, DURVANEI AUGUSTO; TAEMI ORIGASSA, CLARICE SILVIA; ZAMPOLLI, HAMILTON DE CAMPOS; SARAIVA CAMARA, NIELS OLSEN; BERRA, CAROLINA MARIA; et al. Promising pharmacological profile of a Kunitz-type inhibitor in murine renal cell carcinoma model. ONCOTARGET, v. 7, n. 38, p. 62255-62266, . (12/06944-8, 12/02270-2, 10/07958-7, 15/50040-4, 13/07467-1)
RUSSO, LILIAN C.; ARAUJO, CHRISTIANE B.; IWAI, LEO K.; FERRO, EMER S.; FORTI, FABIO L.. A Cyclin D2-derived peptide acts on specific cell cycle phases by activating ERK1/2 to cause the death of breast cancer cells. JOURNAL OF PROTEOMICS, v. 151, n. SI, p. 24-32, . (13/07467-1, 15/03983-0)
DA SILVA, MARCELO SANTOS; SEGATTO, MARCELA; PAVANI, RAPHAEL SOUZA; GUTIERREZ-RODRIGUES, FERNANDA; BISPO, VANDERSON DA SILVA; GENNARI DE MEDEIROS, MARISA HELENA; CALADO, RODRIGO TOCANTINS; ELIAS, MARIA CAROLINA; NOGUEIRA CANO, MARIA ISABEL. Consequences of acute oxidative stress in Leishmania amazonensis: From telomere shortening to the selection of the fittest parasites. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, v. 1864, n. 1, p. 138-150, . (14/24170-5, 13/07937-8, 14/02978-0, 15/10580-0, 13/07467-1)
IQBAL, ASIF; GOLDFEDER, MAURICIO BARBUGIANI; MARQUES-PORTO, RAFAEL; ASIF, HUMA; DE SOUZA, JEAN GABRIEL; FARIA, FERNANDA; CHUDZINSKI-TAVASSI, ANA MARISA. Revisiting antithrombotic therapeutics; sculptin, a novel specific, competitive, reversible, scissile and tight binding inhibitor of thrombin. SCIENTIFIC REPORTS, v. 7, . (13/07467-1, 15/50040-4)
ALMEIDA, DIEGO DANTAS; KITAJIMA, JOAO PAULO; NISHIYAMA, JR., MILTON YUTAKA; CONDOMITTI, GEORGE WILLIAN; DE OLIVEIRA, URSULA CASTRO; SETUBAL, JOAO CARLOS; JUNQUEIRA-DE-AZEVEDO, INACIO L. M.. The complete mitochondrial genome of Bothrops jararaca (Reptilia, Serpentes, Viperidae). MITOCHONDRIAL DNA PART B-RESOURCES, v. 1, p. 907-908, . (13/07467-1, 13/07974-0, 12/00177-5)
ALVES, CERES LUCIANA; REPOLES, BRUNO MARCAL; DA SILVA, MARCELO SANTOS; MENDES, ISABELA CECILIA; MARIN, PAULA ANDREA; NASCIMENTO AGUIAR, PEDRO HENRIQUE; SANTOS, SELMA DA SILVA; FRANCO, GLORIA REGINA; MACEDO, ANDREA MARA; JUNHO PENA, SERGIO DANILO; et al. The recombinase Rad51 plays a key role in events of genetic exchange in Trypanosoma cruzi. SCIENTIFIC REPORTS, v. 8, . (14/24170-5, 13/07467-1, 16/50050-2)
SILVA, MAKSWELL ALMEIDA; LOPES, DAIANA SILVA; TEIXEIRA, SAMUEL COTA; CIRILO GIMENES, SARAH NATALIE; VASCONCELOS AZEVEDO, FERNANDA VAN PETTEN; POLLONI, LORENA; BORGES, BRUNA CRISTINA; DA SILVA, MARCELO SANTOS; BARBOSA, MARCELO JOSE; DE OLIVEIRA JUNIOR, ROBSON JOSE; et al. Genotoxic effects of BnSP-6, a Lys-49 phospholipase A(2) (PLA(2)) homologue from Bothrops pauloensis snake venom, on MDA-MB-231 breast cancer cells. International Journal of Biological Macromolecules, v. 118, n. A, p. 311-319, . (14/24170-5, 13/07467-1)
CRISPIM, MARCELL; DAMASCENO, FLAVIA SILVA; HERNANDEZ, AGUSTINO; BARISON, MARIA JULIA; SAUTER, ISMAEL PRETTO; PAVANI, RAPHAEL SOUZA; MOURA, ALEXANDRE SANTOS; FURUSHO PRAL, ELIZABETH MIEKO; CORTEZ, MAURO; ELIAS, MARIA CAROLINA; et al. The glutamine synthetase of Trypanosoma cruzi is required for its resistance to ammonium accumulation and evasion of the parasitophorous vacuole during host-cell infection. PLoS Neglected Tropical Diseases, v. 12, n. 1, . (14/10443-0, 16/50050-2, 15/10580-0, 13/07467-1, 16/06034-2)
FERREIRA JUNIOR, WILSON ALVES; ZAHARENKO, ANDRE JUNQUEIRA; KAZUMA, KOHEI; PICOLO, GISELE; GUTIERREZ, VANESSA PACCIARI; DE FREITAS, JOSE CARLOS; KONNO, KATSUHIRO; CURY, YARA. Peripheral 5-HT3 Receptors Are Involved in the Antinociceptive Effect of Bunodosine 391. TOXINS, v. 10, n. 1, . (13/07467-1, 09/08089-5, 11/01183-6)
DE LUNA VITORINO, FRANCISCA NATHALIA; MONTONI, FABIO; MORENO, JAQUELINE NEVES; DE SOUZA, BRUNO FERREIRA; LOPES, MARIANA DE CAMARGO; CORDEIRO, BARBARA; FONSECA, CECILIA SELLA; GILMORE, JOSHUA M.; SARDIU, MIHAELA I.; REIS, MARCELO SILVA; et al. FGF2 Antiproliferative Stimulation Induces Proteomic Dynamic Changes and High Expression of FOSB and JUNB in K-Ras-Driven Mouse Tumor Cells. PROTEOMICS, v. 18, n. 17, . (11/22619-7, 13/07467-1)
GUIDOLIN, FELIPE RAIMONDI; CARICATI, CELSO PEREIRA; MARCELINO, JOSE ROBERTO; DA SILVA, WILMAR DIAS. Development of Equine IgG Antivenoms against Major Snake Groups in Mozambique. PLoS Neglected Tropical Diseases, v. 10, n. 1, . (13/07467-1)
CASTIBLANCO-VALENCIA, MONICA MARCELA; FRAGA, TATIANA RODRIGUES; PAGOTTO, ANA HELENA; DE TOLEDO SERRANO, SOLANGE MARIA; ESTIMA ABREU, PATRICIA ANTONIA; BARBOSA, ANGELA SILVA; ISAAC, LOURDES. Plasmin cleaves fibrinogen and the human complement proteins C3b and C5 in the presence of Leptospira interrogans proteins: A new role of LigA and LigB in invasion and complement immune evasion. Immunobiology, v. 221, n. 5, p. 679-689, . (13/07467-1, 10/50043-0)
CORREA, MARA A.; OKAMOTO, CINTHYA K.; GONCALVES-DE-ANDRADE, RUTE M.; VAN DEN BERG, CARMEN W.; TAMBOURGI, DENISE V.. Sphingomyelinase D from Loxosceles laeta Venom Induces the Expression of MMP7 in Human Keratinocytes: Contribution to Dermonecrosis. PLoS One, v. 11, n. 4, . (13/07467-1)
DOS SANTOS, JANAINA CARDOSO; GRUND, LIDIANE ZITO; SEIBERT, CARLA SIMONE; MARQUES, ELINEIDE EUGENIO; SOARES, ANDERSON BRITO; QUESNIAUX, VALERIE F.; RYFFEL, BERNHARD; LOPES-FERREIRA, MONICA; LIMA, CARLA. Stingray venom activates IL-33 producing cardiomyocytes, but not mast cell, to promote acute neutrophil-mediated injury. SCIENTIFIC REPORTS, v. 7, . (13/07467-1, 15/12225-2, 15/12224-6)
FREITAS-DE-SOUSA, LUCIANA APARECIDA; COLOMBINI, MONICA; LOPES-FERREIRA, MONICA; SERRANO, SOLANGE M. T.; MOURA-DA-SILVA, ANA MARIA. Insights into the Mechanisms Involved in Strong Hemorrhage and Dermonecrosis Induced by Atroxlysin-Ia, a PI-Class Snake Venom Metalloproteinase. TOXINS, v. 9, n. 8, . (13/07467-1, 16/50127-5, 14/26058-8)
CAMPOS, POLLYANNA FERNANDES; ANDRADE-SILVA, DEBORA; ZELANIS, ANDRE; PAES LEME, ADRIANA FRANCO; TEIXEIRA ROCHA, MARISA MARIA; MENEZES, MILENE CRISTINA; SERRANO, SOLANGE M. T.; MEIRELLES JUNQUEIRA-DE-AZEVE, INACIO DE LOIOLA. Trends in the Evolution of Snake Toxins Underscored by an Integrative Omics Approach to Profile the Venom of the Colubrid Phalotris mertensi. GENOME BIOLOGY AND EVOLUTION, v. 8, n. 8, p. 2266-2287, . (13/07467-1)
JUNQUEIRA-DE-AZEVEDO, INACIO L. M.; CAMPOS, POLLYANNA F.; CHING, ANA T. C.; MACKESSY, STEPHEN P.. Colubrid Venom Composition: An -Omics Perspective. TOXINS, v. 8, n. 8, . (13/07467-1, 12/00177-5)
ANDRADE-SILVA, DEBORA; ZELANIS, ANDRE; KITANO, EDUARDO S.; JUNQUEIRA-DE-AZEVEDO, INACIO L. M.; REIS, MARCELO S.; LOPES, ALINE S.; SERRANO, SOLANGE M. T.. Proteomic and Glycoproteomic Profilings Reveal That Post- translational Modifications of Toxins Contribute to Venom Phenotype in Snakes. JOURNAL OF PROTEOME RESEARCH, v. 15, n. 8, p. 2658-2675, . (13/07467-1, 13/13548-4)
GARCIA, P. R. A. F.; BICEV, R. N.; OLIVEIRA, C. L. P.; SANT'ANNA, O. A.; FANTINI, M. C. A.. Protein encapsulation in SBA-15 with expanded pores. Microporous and Mesoporous Materials, v. 235, p. 59-68, . (13/07467-1)
BRANCO, VANIA G.; IQBAL, ASIF; ALVAREZ-FLORES, MIRYAM P.; SCIANI, JULIANA M.; DE ANDRADE, SONIA A.; IWAI, LEO K.; SERRANO, SOLANGE M. T.; CHUDZINSKI-TAVASSI, ANA M.. Amblyomin-X having a Kunitz-type homologous domain, is a noncompetitive inhibitor of FXa and induces anticoagulation in vitro and in vivo. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, v. 1864, n. 10, p. 1428-1435, . (13/07467-1, 15/50040-4)
CHAVES, ALISON F. A.; CASTILHO, DANIELE G.; NAVARRO, MARINA V.; OLIVEIRA, ANA K.; SERRANO, SOLANGE M. T.; TASHIMA, ALEXANDRE K.; BATISTA, WAGNER L.. Phosphosite-specific regulation of the oxidative-stress response of Paracoccidioides brasiliensis: a shotgun phosphoproteomic analysis. Microbes and Infection, v. 19, n. 1, p. 34-46, . (14/13961-1, 11/14392-2, 13/07467-1, 12/19321-9, 12/17530-0)
MARIN, PAULA ANDREA; DA SILVA, MARCELO SANTOS; PAVANI, RAPHAEL SOUZA; MACHADO, CARLOS RENATO; ELIAS, MARIA CAROLINA. Recruitment kinetics of the homologous recombination pathway in procyclic forms of Trypanosoma brucei after ionizing radiation treatment. SCIENTIFIC REPORTS, v. 8, . (15/10580-0, 13/07467-1, 16/50050-2, 14/24170-5)
ZAMBELLI, VANESSA O.; PICOLO, GISELE; FERNANDES, CARLOS A. H.; FONTES, MARCOS R. M.; CURY, YARA. Secreted Phospholipases A(2) from Animal Venoms in Pain and Analgesia. TOXINS, v. 9, n. 12, . (13/07467-1, 15/01254-1, 11/17974-2)
ALVAREZ-FLORES, MILYAM P.; HEBERT, AUDREY; GOUELLE, CATHY; GELLER, SARAH; CHUDZINSKI-TAVASSI, ANA M.; PELLERIN, LUC. Neuroprotective effect of rLosac on supplement-deprived mouse cultured cortical neurons involves maintenance of monocarboxylate transporter MCT2 protein levels. Journal of Neurochemistry, v. 148, n. 1, p. 80-96, . (13/07467-1, 15/50040-4)
BORGES, ALYSSA R.; TOLEDO, DANIEL A.; FERMINO, BRUNO R.; DE OLIVEIRA, JOSE CARLOS; SILBER, ARIEL MARIANO; ELIAS, MARIA CAROLINA; D'AVILA, HELOISA; SCOPEL, KEZIA K. G.. In Vitro Cellular Division of Trypanosoma abeli Reveals Two Pathways for Organelle Replication. Journal of Eukaryotic Microbiology, v. 66, n. 3, p. 385-392, . (13/07467-1)
DE ARAUJO, CHRISTIANE B.; CALDERANO, SIMONE G.; ELIAS, MARIA CAROLINA. The Dynamics of Replication in Trypanosoma cruzi Parasites by Single-Molecule Analysis. Journal of Eukaryotic Microbiology, v. 66, n. 3, p. 514-518, . (13/07467-1, 16/50050-2, 14/13375-5)
ZAMBELLI, VANESSA O.; CHEN, CHE-HONG; GROSS, ERIC R.. Reactive aldehydes: an initial path to develop precision medicine for pain control. ANNALS OF TRANSLATIONAL MEDICINE, v. 3, n. 17, . (13/07467-1)
ATASHPAZ-GARGARI, ESMAEIL; REIS, MARCELO S.; BRAGA-NETO, ULISSES M.; BARRERA, JUNIOR; DOUGHERTY, EDWARD R.. A fast Branch-and-Bound algorithm for U-curve feature selection. PATTERN RECOGNITION, v. 73, p. 172-188, . (13/07467-1, 15/01587-0)
LIMA DINIZ, LAURA CRISTINA; MIRANDA, ANTONIO; DA SILVA, JR., PEDRO ISMAEL. Human Antimicrobial Peptide Isolated From Triatoma infestans Haemolymph, Trypanosoma cruzi-Transmitting Vector. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 8, . (13/07467-1)
DE LIMA, LOYZE P.; CALDERANO, SIMONE G.; DA SILVA, MARCELO S.; DE ARAUJO, CHRISTIANE B.; VASCONCELOS, ELTON J. R.; IWAI, LEO K.; PEREIRA, CLAUDIO A.; FRAGOSO, STENIO P.; CAROLINA ELIAS, M.. Ortholog of the polymerase theta helicase domain modulates DNA replication in Trypanosoma cruzi. SCIENTIFIC REPORTS, v. 9, . (14/24170-5, 13/07467-1, 16/50050-2, 14/13375-5)
BOUFLEUR, PAMELA; SCIANI, JULIANA MOZER; GOLDFEDER, MAURICIO; FARIA, FERNANDA; BRANCO, VANIA; CHUDZINSKI-TAVASSI, ANA MARISA. Biodistribution and Pharmacokinetics of Amblyomin-X, a Novel Antitumour Protein Drug in Healthy Mice. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, v. 44, n. 1, p. 111-120, . (13/07467-1)
DA SILVA, MARCELO S.; PAVANI, RAPHAEL S.; DAMASCENO, JEZIEL D.; MARQUES, CATARINA A.; MCCULLOCH, RICHARD; ORSINI TOSI, LUIZ RICARDO; ELIAS, MARIA CAROLINA. Nuclear DNA Replication in Trypanosomatids: There Are No Easy Methods for Solving Difficult Problems. Trends in Parasitology, v. 33, n. 11, p. 858-874, . (15/10580-0, 13/07467-1, 16/50050-2, 14/24170-5)
DA SILVA, MARCELO SANTOS; MARIN MUNOZ, PAULA ANDREA; ARMELIN, HUGO AGUIRRE; ELIAS, MARIA CAROLINA. Differences in the Detection of BrdU/EdU Incorporation Assays Alter the Calculation for G1, S, and G2 Phases of the Cell Cycle in Trypanosomatids. Journal of Eukaryotic Microbiology, v. 64, n. 6, p. 756-770, . (15/10580-0, 13/07467-1, 14/24170-5)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.