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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Exploring the in vivo wound healing effects of a recombinant hemolin from the caterpillar Lonomia obliqua

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Author(s):
Sato, Ana Claudia ; Bosch, Rosemary Viola ; Alves Will, Sonia Elisabete ; Alvarez-Flores, Miryam Paola ; Goldfeder, Mauricio Barbugiani ; Mesquita Pasqualoto, Kerly Fernanda ; Vaz Galvao da Silva, Brbara Athayde ; de Andrade, Sonia Aparecida ; Chudzinski-Tavassi, Ana Marisa
Total Authors: 9
Document type: Journal article
Source: Journal of Venomous Animals and Toxins including Tropical Diseases; v. 22, DEC 21 2016.
Web of Science Citations: 1
Abstract

Background: Hemolin proteins are cell adhesion molecules from lepidopterans involved in a wide range of cell interactions concerning their adhesion properties. However, hemolin's roles in cell proliferation and wound healing are not fully elucidated. It has been recently reported that rLosac, a recombinant hemolin from the caterpillar Lonomia obliqua, presents antiapoptotic activity and is capable of improving in vitro wound healing. Therefore, this study aimed to explore rLosac's in vivo effects using a skin wound healing model in rats. Methods: Circular full-thickness wounds in the rat dorsum skin were treated either with rLosac, or with saline (control), allowing healing by keeping the wounds occluded and moist. During the wound healing, the following tissue regeneration parameters were evaluated: wound closure and collagen content. Furthermore, tissue sections were subjected to histological and immunohistochemical analyses. Results: The rLosac treatment has demonstrated its capacity to improve wound healing, as reflected in findings of a larger number of activated fibroblasts, proliferation of epithelial cells, increase of collagen type 1, and decrease of inflammatory infiltrate. Conclusion: The findings have indicated the rLosac protein as a very promising molecule for the development of new wound-healing formulations. (AU)

FAPESP's process: 13/07467-1 - CeTICS - Center of Toxins, Immune-Response and Cell Signaling
Grantee:Hugo Aguirre Armelin
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 13/06892-0 - Multifunctional molecules from Lonomia obliqua caterpillar: designing of new chemical entities and interrelationship with cellular mechanisms
Grantee:Ana Marisa Chudzinski-Tavassi
Support type: Regular Research Grants