de Araujo, Christiane B.
Calderano, Simone G.
Elias, Maria Carolina
Total Authors: 3
 Inst Butantan, Lab Especial Ciclo Celular, Ave Vital Brasil 1500, BR-05503900 Sao Paulo - Brazil
 Inst Butantan, Ctr Toxins Immune Response & Cell Signaling CeTIC, Ave Vital Brasil 1500, BR-05503900 Sao Paulo - Brazil
 Inst Butantan, Lab Parasitol, Ave Vital Brasil 1500, BR-05503900 Sao Paulo - Brazil
Total Affiliations: 3
Journal of Eukaryotic Microbiology;
Web of Science Citations:
Here, we investigated the features of replication in Trypanosoma cruzi epimastigotes based on fork speed progression, which is influenced by distinct features such as DNA polymerase rate, susceptibility to DNA damage and repair, secondary structures, transcription and chromatin state. Although T. cruzi exhibits a mean fork speed (2.05 +/- 0.10 kb/min) very similar to other trypanosomatids, we found that the majority of DNA molecules replicated more slowly, with a frequency distribution approximately 1 kb/min. This frequency distribution analysis provides more information about the replication profile of this organism. (AU)