| Full text | |
| Author(s): |
Total Authors: 3
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| Affiliation: | [1] Inst Butantan, Lab Especial Ciclo Celular, Ave Vital Brasil 1500, BR-05503900 Sao Paulo - Brazil
[2] Inst Butantan, Ctr Toxins Immune Response & Cell Signaling CeTIC, Ave Vital Brasil 1500, BR-05503900 Sao Paulo - Brazil
[3] Inst Butantan, Lab Parasitol, Ave Vital Brasil 1500, BR-05503900 Sao Paulo - Brazil
Total Affiliations: 3
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| Document type: | Journal article |
| Source: | Journal of Eukaryotic Microbiology; v. 66, n. 3, p. 514-518, MAY-JUN 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
Here, we investigated the features of replication in Trypanosoma cruzi epimastigotes based on fork speed progression, which is influenced by distinct features such as DNA polymerase rate, susceptibility to DNA damage and repair, secondary structures, transcription and chromatin state. Although T. cruzi exhibits a mean fork speed (2.05 +/- 0.10 kb/min) very similar to other trypanosomatids, we found that the majority of DNA molecules replicated more slowly, with a frequency distribution approximately 1 kb/min. This frequency distribution analysis provides more information about the replication profile of this organism. (AU) | |
| FAPESP's process: | 13/07467-1 - CeTICS - Center of Toxins, Immune-Response and Cell Signaling |
| Grantee: | Hugo Aguirre Armelin |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 16/50050-2 - How do common and diverged features of the replicative stress response shape the biology of TriTryp parasites? |
| Grantee: | Maria Carolina Quartim Barbosa Elias Sabbaga |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 14/13375-5 - Replication origins in trypanosomes |
| Grantee: | Christiane Bezerra de Araujo |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |