Effect of nanoencapsulation of blueberry (Vaccinium myrtillus): A green source of flavonoids with antioxidant and photoprotective properties

Autor(es)

Franco, Julia Gomes ^[1] ; Cefali, Leticia Caramori ^{[2, 3]} ; Ataide, Janaina Artem ^{[1, 3]} ; Santini, Antonello ^[4] ; Souto, Eliana B. ^{[5, 3]} ; Mazzola, Priscila Gava ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Fac Pharmaceut Sci, UNICAMP, Rua Candido Portinari 200, BR-13083871 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Inst Biol, UNICAMP, R Monteiro Lobato 255, BR-13083862 Campinas, SP - Brazil

^[3] Univ Coimbra UC, Fac Pharm, Dept Pharmaceut Technol, Polo Ciencias Saude, P-3000548 Coimbra - Portugal

^[4] Univ Napoli Federico II, Dept Pharm, I-80131 Naples - Italy

^[5] Univ Minho, CEB Ctr Biol Engn, Campus Gualtar, P-4710057 Braga - Portugal

• Tipo de documento: Artigo Científico
• Fonte: SUSTAINABLE CHEMISTRY AND PHARMACY; v. 23, OCT 2021.
• Citações Web of Science: 0

Resumo

The effect of nanoencapsulation on the in vitro photoprotection and antioxidant properties of blueberry (Vaccinium myrtillus) extract, before and after their dispersion into an oil-in-water emulsion and its final stability under stress conditions. Besides its skin healing activity, chitosan was chosen as wall material due to its natural origin, and possibility of obtention from shrimp residues. Chitosan/tripolyphosphate (TPP) nanoparticles loaded with blueberry extract were produced and characterized. Three different semi-solid oil-in-water emulsions, using Ecocert certified materials, were developed containing, respectively, (i) 5% (wt/wt) of extract-free nanoparticles, (ii) 5% (wt/wt) of extract-loaded nanoparticles, (iii) 2% (wt/wt) of free extract. Sun protection factor (SPF), antioxidant activity and stability under stress conditions were evaluated. The concentration of rutin was determined by High Performance Liquid Chromatography (HPLC). The loading of blueberry extract into nanoparticles kept their physicochemical properties, as well as SPF and antioxidant activity, over the course of the stability study. Extract-loaded nanoparticles were dispersed in a semi-solid oil-in-water emulsion and were shown to protect the extract from oxidation, suggesting that formulation containing 5% (wt/wt) of extract-free nanoparticles could presented lower difference between initial and final SPF and antioxidant activity values after 90 days of analysis. The developed formulation is proposed as a greener potential formulation to be used as photoprotector, especially if associated with physical sun filters. The role of blueberry flavonoids and the synergistic effect of nanoparticles against skin aging are here discussed. (AU)

• Processo FAPESP: 15/25533-7 - Desenvolvimento e avaliação do fator de proteção solar de emulsão contendo extrato rico em flavonóides
• Beneficiário: Leticia Caramori Cefali
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 17/14757-7 - Desenvolvimento e avaliação do fator de proteção solar de emulsão contendo extrato rico em flavonoides
• Beneficiário: Leticia Caramori Cefali
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 17/05275-9 - Encapsulação de bromelina: estabilidade, perfis de libertação e citotoxicidade
• Beneficiário: Janaína Artem Ataide
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Mestrado