| Full text | |
| Author(s): |
Franco, Julia Gomes
[1]
;
Cefali, Leticia Caramori
[2, 3]
;
Ataide, Janaina Artem
[1, 3]
;
Santini, Antonello
[4]
;
Souto, Eliana B.
[5, 3]
;
Mazzola, Priscila Gava
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Estadual Campinas, Fac Pharmaceut Sci, UNICAMP, Rua Candido Portinari 200, BR-13083871 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Inst Biol, UNICAMP, R Monteiro Lobato 255, BR-13083862 Campinas, SP - Brazil
[3] Univ Coimbra UC, Fac Pharm, Dept Pharmaceut Technol, Polo Ciencias Saude, P-3000548 Coimbra - Portugal
[4] Univ Napoli Federico II, Dept Pharm, I-80131 Naples - Italy
[5] Univ Minho, CEB Ctr Biol Engn, Campus Gualtar, P-4710057 Braga - Portugal
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | SUSTAINABLE CHEMISTRY AND PHARMACY; v. 23, OCT 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
The effect of nanoencapsulation on the in vitro photoprotection and antioxidant properties of blueberry (Vaccinium myrtillus) extract, before and after their dispersion into an oil-in-water emulsion and its final stability under stress conditions. Besides its skin healing activity, chitosan was chosen as wall material due to its natural origin, and possibility of obtention from shrimp residues. Chitosan/tripolyphosphate (TPP) nanoparticles loaded with blueberry extract were produced and characterized. Three different semi-solid oil-in-water emulsions, using Ecocert certified materials, were developed containing, respectively, (i) 5% (wt/wt) of extract-free nanoparticles, (ii) 5% (wt/wt) of extract-loaded nanoparticles, (iii) 2% (wt/wt) of free extract. Sun protection factor (SPF), antioxidant activity and stability under stress conditions were evaluated. The concentration of rutin was determined by High Performance Liquid Chromatography (HPLC). The loading of blueberry extract into nanoparticles kept their physicochemical properties, as well as SPF and antioxidant activity, over the course of the stability study. Extract-loaded nanoparticles were dispersed in a semi-solid oil-in-water emulsion and were shown to protect the extract from oxidation, suggesting that formulation containing 5% (wt/wt) of extract-free nanoparticles could presented lower difference between initial and final SPF and antioxidant activity values after 90 days of analysis. The developed formulation is proposed as a greener potential formulation to be used as photoprotector, especially if associated with physical sun filters. The role of blueberry flavonoids and the synergistic effect of nanoparticles against skin aging are here discussed. (AU) | |
| FAPESP's process: | 15/25533-7 - DEVELOPMENT AND EVALUATION OF A FLAVONOID ENRICHED EMULSION WITH SUN PROTECTION FACTOR |
| Grantee: | Leticia Caramori Cefali |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 17/14757-7 - Development and evaluation of sun protection factor of emulsion containing extract rich in flavonoids |
| Grantee: | Leticia Caramori Cefali |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |
| FAPESP's process: | 17/05275-9 - Bromelain encapsulation: stability, release profile, and cytotoxicity |
| Grantee: | Janaína Artem Ataide |
| Support Opportunities: | Scholarships abroad - Research Internship - Master's degree |