Molecular basis of synchronous replication of malaria parasites in the blood stage

Autor(es)

Dos Santos, Benedito M. ^[1] ; Pereira, Pedro H. S. ^[1] ; Garcia, Celia R. S. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Clin & Toxicol Anal, Lab Funct Genom & Antimalarial Discovery, Sch Pharmaceut Sci, BR-05508000 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Current Opinion in Microbiology; v. 63, p. 210-215, OCT 2021.
• Citações Web of Science: 0

Resumo

The search for host factors that leads to malaria parasite synchronization has been the focus of several laboratories. The host hormone melatonin synchronizes Plasmodium falciparum in culture by increasing the number of mature parasite stages through a PLC-IP3 activation. Melatonin signaling is linked to crosstalk between Ca2+-cAMP that results in PKA activation. Two other kinases, PfPK7 and PfelK1, and the nuclear protein PfMORC that lacks melatonin sensitivity in the inducible knock-down parasites are also identified as part of the hormone-signal transduction pathways. Melatonin also modulates P. falciparum mitochondrial fission genes FIS1, DYN1, and DYN2 in a stage-specific manner. How these multiple molecular mechanisms are orchestrated to lead to parasite synchronization is a fascinating and opened biological question. (AU)

• Processo FAPESP: 17/08684-7 - Decodificar aspectos da biologia celular e molecular do Plasmodium como uma ferramenta para desenvolver novos antimaláricos
• Beneficiário: Célia Regina da Silva Garcia
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 20/08988-9 - Avaliação de compostos com potencial antimalárico e estudo do mecanismo de transdução de sinal do GPCR (G-Protein Coupled Receptor) like PfSR25 em Plasmodium falciparum
• Beneficiário: Benedito Matheus dos Santos
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto