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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Taurine Chloramine and Hydrogen Peroxide as a Potential Source of Singlet Oxygen for Topical Application

Texto completo
Autor(es):
Ximenes, Valdecir F. [1] ; Ximenes, Thomaz P. [1] ; Morgon, Nelson H. [2] ; de Souza, Aguinaldo R. [1]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] UNESP Sao Paulo State Univ, Fac Sci, Dept Chem, Bauru, SP - Brazil
[2] Campinas State Univ UNICAMP, Inst Chem, Dept Phys Chem, Campinas, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Photochemistry and Photobiology; v. 97, n. 5, p. 963-970, SEP 2021.
Citações Web of Science: 0
Resumo

Singlet oxygen (O-1(2)) is the ``active principle{''} in photodynamic therapy. Taurine chloramine (Tau-NHCl) and hydrogen peroxide (H2O2) are well-tolerated and widely used antiseptics. Due to its mild oxidizing features and stability, Tau-NHCl can be directly used to treat skin diseases. We found that a diluted aqueous mixture of Tau-NHCl and H2O2 acts as a slow and long-lasting potential source of O-1(2). The reactions were studied by luminol-enhanced chemiluminescence. Evidence of the formation of O-1(2) was obtained using deuterium oxide, sodium azide and 9,10-Anthracenediyl-bis(methylene)dimalonic acid, a chemical trap of O-1(2). The reaction was optimized, and a mechanism was proposed, including theoretical calculations at B3LYP/6-311++G(3df,2p) level of theory, adding D3Bj empirical dispersion and SMD (Water) solvent effects. Chloramines produced by the reactions between HOCl and L-alanine, 3-amino-1-propanesulfonic acid and gamma-aminobutyric acid were also prepared, and their reactivity and stability were compared with Tau-NHCl. We found that Tau-NHCl is more stable and adequate for the production of O-1(2). In conclusion, we propose applying these drugs combination as a potential source of O-1(2) with applications for skin diseases treatment. (AU)

Processo FAPESP: 19/18445-5 - Síntese, estudos e aplicações de sondas fluorescentes e circular dicroicas para caracterização de interações com proteínas, DNA e determinação de atividade enzimática
Beneficiário:Valdecir Farias Ximenes
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 16/20549-5 - Desenvolvimento e aplicação de sondas fluorescentes e baseadas em dicroísmo circular para estudos de interação de ligantes com proteínas, caracterização de proteínas amiloides e determinação de atividade enzimática
Beneficiário:Valdecir Farias Ximenes
Modalidade de apoio: Auxílio à Pesquisa - Regular