| Texto completo | |
| Autor(es): |
Ximenes, Valdecir F.
[1]
;
Ximenes, Thomaz P.
[1]
;
Morgon, Nelson H.
[2]
;
de Souza, Aguinaldo R.
[1]
Número total de Autores: 4
|
| Afiliação do(s) autor(es): | [1] UNESP Sao Paulo State Univ, Fac Sci, Dept Chem, Bauru, SP - Brazil
[2] Campinas State Univ UNICAMP, Inst Chem, Dept Phys Chem, Campinas, SP - Brazil
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Photochemistry and Photobiology; v. 97, n. 5, p. 963-970, SEP 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
Singlet oxygen (O-1(2)) is the ``active principle{''} in photodynamic therapy. Taurine chloramine (Tau-NHCl) and hydrogen peroxide (H2O2) are well-tolerated and widely used antiseptics. Due to its mild oxidizing features and stability, Tau-NHCl can be directly used to treat skin diseases. We found that a diluted aqueous mixture of Tau-NHCl and H2O2 acts as a slow and long-lasting potential source of O-1(2). The reactions were studied by luminol-enhanced chemiluminescence. Evidence of the formation of O-1(2) was obtained using deuterium oxide, sodium azide and 9,10-Anthracenediyl-bis(methylene)dimalonic acid, a chemical trap of O-1(2). The reaction was optimized, and a mechanism was proposed, including theoretical calculations at B3LYP/6-311++G(3df,2p) level of theory, adding D3Bj empirical dispersion and SMD (Water) solvent effects. Chloramines produced by the reactions between HOCl and L-alanine, 3-amino-1-propanesulfonic acid and gamma-aminobutyric acid were also prepared, and their reactivity and stability were compared with Tau-NHCl. We found that Tau-NHCl is more stable and adequate for the production of O-1(2). In conclusion, we propose applying these drugs combination as a potential source of O-1(2) with applications for skin diseases treatment. (AU) | |
| Processo FAPESP: | 19/18445-5 - Síntese, estudos e aplicações de sondas fluorescentes e circular dicroicas para caracterização de interações com proteínas, DNA e determinação de atividade enzimática |
| Beneficiário: | Valdecir Farias Ximenes |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 16/20549-5 - Desenvolvimento e aplicação de sondas fluorescentes e baseadas em dicroísmo circular para estudos de interação de ligantes com proteínas, caracterização de proteínas amiloides e determinação de atividade enzimática |
| Beneficiário: | Valdecir Farias Ximenes |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |