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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Taurine Chloramine and Hydrogen Peroxide as a Potential Source of Singlet Oxygen for Topical Application

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Author(s):
Ximenes, Valdecir F. [1] ; Ximenes, Thomaz P. [1] ; Morgon, Nelson H. [2] ; de Souza, Aguinaldo R. [1]
Total Authors: 4
Affiliation:
[1] UNESP Sao Paulo State Univ, Fac Sci, Dept Chem, Bauru, SP - Brazil
[2] Campinas State Univ UNICAMP, Inst Chem, Dept Phys Chem, Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Photochemistry and Photobiology; v. 97, n. 5, p. 963-970, SEP 2021.
Web of Science Citations: 0
Abstract

Singlet oxygen (O-1(2)) is the ``active principle{''} in photodynamic therapy. Taurine chloramine (Tau-NHCl) and hydrogen peroxide (H2O2) are well-tolerated and widely used antiseptics. Due to its mild oxidizing features and stability, Tau-NHCl can be directly used to treat skin diseases. We found that a diluted aqueous mixture of Tau-NHCl and H2O2 acts as a slow and long-lasting potential source of O-1(2). The reactions were studied by luminol-enhanced chemiluminescence. Evidence of the formation of O-1(2) was obtained using deuterium oxide, sodium azide and 9,10-Anthracenediyl-bis(methylene)dimalonic acid, a chemical trap of O-1(2). The reaction was optimized, and a mechanism was proposed, including theoretical calculations at B3LYP/6-311++G(3df,2p) level of theory, adding D3Bj empirical dispersion and SMD (Water) solvent effects. Chloramines produced by the reactions between HOCl and L-alanine, 3-amino-1-propanesulfonic acid and gamma-aminobutyric acid were also prepared, and their reactivity and stability were compared with Tau-NHCl. We found that Tau-NHCl is more stable and adequate for the production of O-1(2). In conclusion, we propose applying these drugs combination as a potential source of O-1(2) with applications for skin diseases treatment. (AU)

FAPESP's process: 19/18445-5 - Synthesis, studies and applications of fluorescent and circular dichroic probes for characterization of interactions with proteins, DNA and determination of enzymatic activity
Grantee:Valdecir Farias Ximenes
Support Opportunities: Regular Research Grants
FAPESP's process: 16/20549-5 - Development and application of fluorescent probes and probes based on circular dichroism for the interaction studies of ligands with protein, characterization of amyloid proteins and determination of enzymatic activity
Grantee:Valdecir Farias Ximenes
Support Opportunities: Regular Research Grants