arental high-fat high-sugar diet programming and hypothalamus adipose tissue axis in male Wistar rat

Autor(es)

Cesar, Helena ^[1] ; Sertorio, Marcela Nascimento ^[2] ; de Souza, Esther Alves ^[2] ; Jamar, Giovana ^[3] ; Santamarina, Aline ^[3] ; Juca, Andrea ^[3] ; Casagrande, Breno Picin ^[3] ; Pisani, Luciana Pellegrini ^[3]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo Unifesp, Programa Posgrad Interdisciplinar Ciencias Saude, Santos, SP - Brazil

^[2] Univ Fed Sao Paulo, Programa Posgrad Nutr, Sao Paulo, SP - Brazil

^[3] Univ Fed Sao Paulo, Dept Biociencias, 136 Lab 311, 3 Andar, BR-11015020 Santos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: EUROPEAN JOURNAL OF NUTRITION; v. 61, n. 1 OCT 2021.
• Citações Web of Science: 1

Resumo

Purpose Maternal nutrition during early development and paternal nutrition pre-conception can programme offspring health status. Hypothalamus adipose axis is a target of developmental programming, and paternal and maternal high-fat, high-sugar diet (HFS) may be an important factor that predisposes offspring to develop obesity later in life. This study aims to investigate Wistar rats' maternal and paternal HFS differential contribution on the development, adiposity, and hypothalamic inflammation in male offspring from weaning until adulthood. Methods Male progenitors were fed a control diet (CD) or HFS for 10 weeks before mating. After mating, dams were fed CD or HFS only during pregnancy and lactation. Forming the following male offspring groups: CD-maternal and paternal CD; MH-maternal HFS and paternal CD; PH-maternal CD and paternal HFS; PMH-maternal and paternal HFS. After weaning, male offspring were fed CD until adulthood. Results Maternal HFS diet increased weight, visceral adiposity, and serum total cholesterol levels, and decreased hypothalamic weight in weanling male rats. In adult male offspring, maternal HFS increased weight, glucose levels, and hypothalamic NF kappa Bp65. Paternal HFS diet lowered hypothalamic insulin receptor levels in weanling offspring and glucose and insulin levels in adult offspring. The combined effects of maternal and paternal HFS diets increased triacylglycerol, leptin levels, and hypothalamic inflammation in weanling rats, and increased visceral adiposity in adulthood. Conclusion Male offspring intake of CD diet after weaning reversed part of the effects of parental HFS diet during the perinatal period. However, maternal and paternal HFS diet affected adiposity and hypothalamic inflammation, which remained until adulthood. (AU)

• Processo FAPESP: 17/09646-1 - Efeitos da dieta materna e paterna na programação metabólica da prole com 21 dias até a idade adulta
• Beneficiário: Helena de Cássia César Vallera
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto