ice (Oryza sativa L.) bran preserves cardiac function by modulating pro-inflammatory cytokines and redox state in the myocardium from obese rat

Autor(es):Mostrar menos -

Garcia, Jessica Leite ^[1] ; Vileigas, Danielle Fernandes ^[2] ; Gregolin, Cristina Schmitt ^[1] ; Costa, Mariane Rovero ^[1] ; Francisqueti-Ferron, Fabiane Valentini ^[1] ; Togneri Ferron, Artur Junio ^[1] ; Salome De Campos, Dijon Henrique ^[1] ; Moreto, Fernando ^[1] ; Minatel, Igor Otavio ^[3] ; Zanati Bazan, Silmeia Garcia ^[1] ; Correa, Camila Renata ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Med Sch, Botucatu, SP - Brazil

^[2] Univ Sao Paulo, Inst Chem, Dept Biochem, Sao Paulo - Brazil

^[3] Sao Paulo State Univ UNESP, Inst Biosci, Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: EUROPEAN JOURNAL OF NUTRITION; v. 61, n. 2 OCT 2021.
• Citações Web of Science: 0

Resumo

Purpose This study aimed to evaluate the effect of rice bran (RB) supplementation to a high-sugar fat (HSF) diet on cardiac dysfunction in an experimental obesity model. Methods Male Wistar rats were distributed into three groups: control, high-sugar fat, and high-sugar fat supplemented with 11% RB for 20 weeks. Results HSF diet promoted obesity and metabolic complications. Obese rats showed cardiac structural and functional impairment associated with high levels of interleukin-6, tumoral necrosis factor alpha, and malondialdehyde, and decreased activity of superoxide dismutase and catalase in the myocardium. RB supplementation was able to mitigate obesity and its metabolic alterations in HSF diet-fed animals. Moreover, the RB also prevented structural and functional damage, inflammation, and redox imbalance in the heart of these animals. Conclusion This study suggests that RB supplementation prevents cardiac dysfunction in rats fed on HSF by modulating systemic metabolic complications and inflammation and oxidative stress in the myocardium, representing potential alternative therapy. (AU)

• Processo FAPESP: 18/15294-3 - Influência da intervenção com gama-orizanol na prevenção da síndrome metabólica cardiorreanal de ratos obesos: participação da carbonilação protéica
• Beneficiário: Camila Renata Corrêa
• Modalidade de apoio: Auxílio à Pesquisa - Regular