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Da Silva, Thais Bento Lima
[1, 2]
;
Ordonez, Tiago Nascimento
[1, 3]
;
Bregola, Allan Gustavo
[4]
;
Bahia, Valeria Santoro
[2]
;
Cecchini, Mario Amore
[2, 5]
;
Guimaraes, Henrique Cerqueira
[6]
;
Gambogi, Leandro Boson
[6]
;
Caramelli, Paulo
[6]
;
Balthazar, Marcio Luiz Figueredo
[7]
;
Damasceno, Benito Pereira
[8]
;
Brucki, Sonia Maria Dozzi
;
de Souza, Leonardo Cruz
[6]
;
Nitrini, Ricardo
[2]
;
Yassuda, Monica Sanches
[1, 2]
Número total de Autores: 14
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Sch Arts Sci & Humanities, Gerontol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Neurol, Fac Med, Sao Paulo - Brazil
[3] Univ Ctr United Metropolitan Colleges, Grad Program Appl Stat, Sao Paulo - Brazil
[4] Univ East Anglia, Fac Med & Hlth Sci, Sch Hlth Sci, Norwich, Norfolk - England
[5] Univ Edinburgh, Psychol, Human Cognit Neurosci, Edinburgh, Midlothian - Scotland
[6] Univ Fed Minas Gerais, Univ Hosp, Div Neurol, Belo Horizonte, MG - Brazil
[7] Univ Campinas UNICAMP, Sch Med Sci, Neuroimaging Lab, Campinas - Brazil
[8] Univ Estadual Campinas, Dept Neurol, Campinas - Brazil
Número total de Afiliações: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | FRONTIERS IN NEUROLOGY; v. 12, SEP 30 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
Introduction: Neuropsychiatric symptoms in patients with frontotemporal dementia (FTD) are highly prevalent and may complicate clinical managements.</p> Objective: To test whether the Neuropsychiatry Inventory (NPI) could detect change in neuropsychiatric symptoms and caregiver's distress in patients diagnosed with behavioral variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD) from baseline to a 12-month follow-up and to investigate possible predictors of change in NPI scores.</p> Methods: The sample consisted of 31 patients diagnosed with bvFTD and 28 patients with AD and their caregivers. The Mini-Mental State Examination (MMSE), Addenbrooke's Cognitive Examination Revised (ACE-R), the INECO Frontal Screening (IFS), the Frontal Assessment Battery (FAB), the Executive Interview (EXIT-25) and the NPI were applied. Descriptive statistics, Mann-Whitney U test, Wilcoxon test, Chi square (chi(2)) test and Linear Regression Analysis were used.</p> Results: NPI total and caregiver distress scores were statistically higher among bvFTD patients at both assessment points. MMSE, ACE-R scores significantly declined and NPI Total and Distress scores significantly increased in both groups. In the bvFTD group, age was the only independent predictor variable for the NPI total score at follow up. In the AD group, ACE-R and EXIT-25, conjunctively, were associated with the NPI total score at follow up.</p> Conclusions: In 12 months, cognition declined and neuropsychiatric symptoms increased in bvFTD and AD groups. In the AD group only, cognitive impairment was a significant predictor of change in neuropsychiatric symptoms.</p> (AU) | |
| Processo FAPESP: | 16/07967-2 - Marcadores neurocognitivos para o diagnóstico precoce e diferencial para a Doença de Alzheimer e a demência frontotemporal: variante comportamental |
| Beneficiário: | Monica Sanches Yassuda |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 11/04804-1 - Funcionalidade e desempenho cognitivo na demência fronto-temporal |
| Beneficiário: | Thaís Bento Lima da Silva |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |