Vitamin D deficiency is a risk factor for delayed tooth eruption associated with persistent primary tooth

Autor(es)

Xavier, Thais Aparecida ^{[1, 2]} ; Madalena, Isabela Ribeiro ^[1] ; Bezerra da Silva, Raquel Assed ^[1] ; Bezerra da Silva, Lea Assed ^[1] ; Barbosa Silva, Marcelo Jose ^[3] ; De Rossi, Andiara ^[1] ; Kuchler, Erika Calvano ^[1] ; Fukada, Sandra Yasuyo ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Pediat Dent, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Dept BioMol Sci, Sch Pharmaceut Sci Ribeirao Preto, Ave Cafe, Sao Paulo - Brazil

^[3] Univ Fed Uberlandia, Inst Biomed Sci, Lab Tumor Biomarkers & Osteoimmunol, Uberlandia, MG - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ACTA ODONTOLOGICA SCANDINAVICA; v. 79, n. 8, p. 600-605, NOV 17 2021.
• Citações Web of Science: 0

Resumo

Objective To verify the association between 25(OH)D level and polymorphisms in the vitamin D receptor gene (VDR) with the disturbance in the dental development and eruption. Design A total of 183 children from two datasets were evaluated. The first dataset was a case-control (15:15) designed to assess if persistent primary tooth (PPT) is associate with serum 25(OH)D level and with genetic polymorphisms in VDR. The second dataset of genomic DNA samples from 54 children with delayed tooth eruption (DTE) and 99 controls were analysed to verify if genetic polymorphisms in VDR (rs2228570 and rs739837) are associated with DTE. The 25(OH)D and the genotyping/allele distribution were analysed using the T-test and chi-square test, respectively. Results The level of 25(OH)D in the PPT group (24.9 +/- 6.4 mg/mL) was significantly lower than the control (30.0 +/- 7.0 mg/mL) (p=.047). Our data show that children with 25(OH)D deficiency are more likely to present PPT (OR = 2.36; 95%CI: 1.51, 3.70). The rs739837 and rs2228570 polymorphisms were not associated with DTE (OR = 1.44; 95%CI: 0.87, 2.39 and OR = 0.80; 95%CI: 0.45, 1.44, respectively). Conclusions Vitamin D deficiency is a risk factor for PPT. (AU)

• Processo FAPESP: 15/09034-0 - Efeito da O-GlcNacilação sobre a osteoclastogênese e reabsorção óssea
• Beneficiário: Sandra Yasuyo Fukada Alves
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/06866-5 - Avaliação do papel do estrógeno no desenvolvimento dentofacial
• Beneficiário: Erika Calvano Kuchler
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores