| Texto completo | |
| Autor(es): |
Hernandez, Ana Luisa C. C.
;
Rezende, Thiago J. R.
;
Martinez, Alberto R. M.
;
de Brito, Mariana R.
;
Franca Jr, Marcondes C.
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | MOVEMENT DISORDERS; v. 37, n. 2 OCT 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
Background Spinal cord (SC) damage is a hallmark in Friedreich's ataxia (FRDA). Neuroimaging has been able to capture some SC macroscopic changes, but no study has evaluated microstructural SC white matter (WM) damage in vivo. Objectives We designed a cross-sectional study to evaluate microstructural integrity in SC WM tracts of FRDA patients using diffusion tensor imaging (DTI) with an automated analysis pipeline. Methods Thirty patients and 30 matched healthy controls underwent 3 Tesla (T) magnetic resonance imaging (MRI). We obtained cervical SC T2 and diffusion-weighted imaging (DWI) acquisitions. Images were processed using the Spinal Cord Toolbox v.4.3.0. For levels C2-C5, we measured cross-sectional area (CSA) and WM DTI parameters (axial diffusivity {[}AD], fractional anisotropy {[}FA], radial diffusivity {[}RD], and mean diffusivity {[}MD]). Age, duration, and FARS scores were also obtained. Results Mean age and disease duration of patients were 31 +/- 10 and 11 +/- 9 years, respectively. There was CSA reduction in FRDA amongst all levels. Between-group differences in FA, MD, and RD in total white matter (TWM), dorsal columns (DC), fasciculus gracilis (FG), fasciculus cuneatus (FC), and corticospinal tracts (CST) were present in all levels. FA and RD from TWM, DC, FC, and CST correlated with FARS scores, and in CST they also correlated with disease duration. Conclusion DTI uncovered abnormalities in SC WM tracts, which correlated with clinical features in FRDA. CSA and CST FA in C2 correlated best with disease severity, whereas DC FA showed the largest effect size to differentiate patients and healthy controls. SC WM microstructure is a potential neuroimaging biomarker to be explored in the disease. (c) 2021 International Parkinson and Movement Disorder Society (AU) | |
| Processo FAPESP: | 13/07559-3 - Instituto Brasileiro de Neurociência e Neurotecnologia - BRAINN |
| Beneficiário: | Fernando Cendes |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs |
| Processo FAPESP: | 19/24240-7 - Estudo multimodal do dano medular na Ataxia de Friedreich |
| Beneficiário: | Ana Luisa de Carvalho Cardozo Hernández |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |