Cysteine proteases as potential targets for anti-trypanosomatid drug discovery

Autor(es):Mostrar menos -

Judice, Wagner A. S. ^[1] ; Ferraz, Leticia Silva ^[2] ; Lopes, Rayssa de Mello ^[2] ; Vianna, Luan dos Santos ^[1] ; Siqueira, Fabio da Silva ^[1] ; Di Iorio, Juliana F. ^[1] ; Dalzoto, Laura de Azevedo Maffeis ^[1] ; Trujilho, Mariana Nascimento Romero ^[1] ; Santos, Taiz dos Reis ^[1] ; Machado, Mauricio F. M. ^[1] ; Rodrigues, Tiago ^[2]

Afiliação do(s) autor(es)

^[1] Univ Mogi Cruzes UMC, Ctr Interdisciplinar Invest Bioquim CIIB, Mogi Das Cruzes, SP - Brazil

^[2] Univ Fed ABC UFABC, Ctr Ciencias Nat & Humanas CCNH, Santo Andre, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Bioorganic & Medicinal Chemistry; v. 46, SEP 15 2021.
• Citações Web of Science: 0

Resumo

Leishmaniasis and trypanosomiasis are endemic neglected disease in South America and Africa and considered a significant public health problem, mainly in poor communities. The limitations of the current available therapeutic options, including the lack of specificity, relatively high toxicity, and the drug resistance acquiring, drive the constant search for new targets and therapeutic options. Advances in knowledge of parasite biology have revealed essential enzymes involved in the replication, survival, and pathogenicity of Leishmania and Trypanosoma species. In this scenario, cysteine proteases have drawn the attention of researchers and they are being proposed as promising targets for drug discovery of antiprotozoal drugs. In this systematic review, we will provide an update on drug discovery strategies targeting the cysteine proteases as potential targets for chemotherapy against protozoal neglected diseases. (AU)

• Processo FAPESP: 18/25747-5 - Alterações de morfologia e dinâmica mitocondriais no câncer: compreensão da biologia tumoral e prospecção de novos alvos terapêuticos
• Beneficiário: Tiago Rodrigues
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/25112-4 - Avaliação de moduladores da atividade de proteases envolvidas em processos patológicos
• Beneficiário: Wagner Alves de Souza Júdice
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 19/05936-0 - Produção de metacaspases de leveduras com truncamento do N-terminal e contendo mutações sítio dirigidas e caracterização bioquímica destas enzimas
• Beneficiário: Mauricio Ferreira Marcondes Machado
• Modalidade de apoio: Auxílio à Pesquisa - Regular