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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cysteine proteases as potential targets for anti-trypanosomatid drug discovery

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Author(s):
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Judice, Wagner A. S. [1] ; Ferraz, Leticia Silva [2] ; Lopes, Rayssa de Mello [2] ; Vianna, Luan dos Santos [1] ; Siqueira, Fabio da Silva [1] ; Di Iorio, Juliana F. [1] ; Dalzoto, Laura de Azevedo Maffeis [1] ; Trujilho, Mariana Nascimento Romero [1] ; Santos, Taiz dos Reis [1] ; Machado, Mauricio F. M. [1] ; Rodrigues, Tiago [2]
Total Authors: 11
Affiliation:
[1] Univ Mogi Cruzes UMC, Ctr Interdisciplinar Invest Bioquim CIIB, Mogi Das Cruzes, SP - Brazil
[2] Univ Fed ABC UFABC, Ctr Ciencias Nat & Humanas CCNH, Santo Andre, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Bioorganic & Medicinal Chemistry; v. 46, SEP 15 2021.
Web of Science Citations: 0
Abstract

Leishmaniasis and trypanosomiasis are endemic neglected disease in South America and Africa and considered a significant public health problem, mainly in poor communities. The limitations of the current available therapeutic options, including the lack of specificity, relatively high toxicity, and the drug resistance acquiring, drive the constant search for new targets and therapeutic options. Advances in knowledge of parasite biology have revealed essential enzymes involved in the replication, survival, and pathogenicity of Leishmania and Trypanosoma species. In this scenario, cysteine proteases have drawn the attention of researchers and they are being proposed as promising targets for drug discovery of antiprotozoal drugs. In this systematic review, we will provide an update on drug discovery strategies targeting the cysteine proteases as potential targets for chemotherapy against protozoal neglected diseases. (AU)

FAPESP's process: 18/25747-5 - Alterations of mitochondrial morphology and dynamics in cancer: understanding of tumor biology and prospecting new therapeutic targets
Grantee:Tiago Rodrigues
Support Opportunities: Regular Research Grants
FAPESP's process: 16/25112-4 - Evaluation of modulators of the activity of proteases involved in pathological processes
Grantee:Wagner Alves de Souza Júdice
Support Opportunities: Regular Research Grants
FAPESP's process: 19/05936-0 - Production of yeast metacaspases with N-terminal depletion and containing site-directed mutations and biochemical characterization of these enzymes
Grantee:Mauricio Ferreira Marcondes Machado
Support Opportunities: Regular Research Grants