Mixture design and physicochemical characterization of amino acid-based DEEP eutectic solvents (AADES) for sample preparation prior to elemental analysis

Autor(es)

Guimaraes, Taciana G. S. ^[1] ; Andrade, Daniel F. ^[2] ; Santana, Ana P. R. ^[3] ; Moser, Poliana ^[4] ; Ferreira, Sabrina S. ^[1] ; Menezes, Iohanna M. N. R. ^[5] ; Amaral, Clarice D. B. ^[5] ; Oliveira, Andrea ^[5] ; Gonzalez, Mario H. ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Natl Inst Alternat Technol Detect Toxicol Evaluat, Dept Chem & Environm Sci, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil

^[2] Univ Fed Sao Carlos, Dept Chem, Appl Instrumental Anal Grp, BR-13565905 Sao Carlos, SP - Brazil

^[3] Univ Fed Minas Gerais, Dept Chem, BR-31270901 Belo Horizonte, MG - Brazil

^[4] Sao Paulo State Univ UNESP, Dept Food Engn & Technol, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil

^[5] Univ Fed Parana, Dept Chem, BR-81531980 Curitiba, Parana - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF MOLECULAR LIQUIDS; v. 345, JAN 1 2022.
• Citações Web of Science: 0

Resumo

Amino acid-based deep eutectic solvents (AADES) represent a new subclass of deep eutectic solvents (DES) in which at least one of the components must be an amino acid, offering advantages such as low toxicity, biodegradability and low cost. In this work, beta-alanine was used as hydrogen bond acceptor (HBA) in the preparation of a total of 30 AADES mixtures, with the hydrogen bond donor (HBD) being malic acid (AADES 1), citric acid (AADES 2), or xylitol (AADES 3), together with the addition of water. A restricted mixture design was employed to optimize the ideal proportions of the AADES components, which were determined as (% m m(-1)) 12.50 for beta-alanine, 43.75 for the HBD component, and 43.75 for water (represented by molar ratio 1:2:17 for the three AADES mixtures), with lower values of density and viscosity being the desired responses. Solvents that have low density and viscosity provide greater efficiency in sample preparation procedures, due to faster mass transfer. The highest density and viscosity values were found for AADES 2, due to the greater presence of carboxyl groups in the molecular structure of citric acid, allowing the formation of more hydrogen interactions. The Herschel-Bulkley model provided the best fit to the rheological behavior of the AADES, with AADES 2 showing the highest consistency index. Solvatochromic analyses showed that these solvents had high polarity. Fourier transform infrared (FTIR) spectroscopy analysis revealed hydrogen interactions between the precursor components, confirming formation of the AADES. Thermal analysis revealed the ideal working temperature ranges for applying these solvents in sample preparation, with thermogravimetry (TGA) indicating maximum temperatures of 130 degrees C for AADES 1 and 150 degrees C for AADES 2 and AADES 3. Differential scanning calorimetry (DSC) revealed the minimum temperatures at which the solvents remained liquids, which were -13 degrees C for AADES 1, -22 degrees C for AADES 2, and -21 degrees C for AADES 3. Therefore, these AADES were shown to be promising solvents for application in sample preparation, being suitable for the extraction of polar compounds, as well as metals and semimetals. An EcoScale study was carried out, which confirmed that the preparation of the solvents could be considered an excellent green synthesis. (C) 2021 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 14/50945-4 - INCT 2014: Instituto Nacional de Tecnologias Alternativas para Detecção, Avaliação Toxicológica e Remoção de Micropoluentes e Radioativos
• Beneficiário: Maria Valnice Boldrin
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 15/14488-0 - Desenvolvimento de métodos analíticos para a determinação da qualidade de fertilizantes e resíduos de curtumes
• Beneficiário: Ana Rita de Araujo Nogueira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/23066-4 - O papel das substâncias húmicas aquáticas na disponibilidade de metais tóxicos e proposta de um indicador para labilidade de matéria orgânica em ambientes aquáticos
• Beneficiário: Márcia Cristina Bisinoti
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/17304-0 - Proposição de métodos para a análise direta de amostras de lixo eletrônico: determinação de elementos preciosos, estratégicos e tóxicos em circuitos eletrônicos e telas touch screen
• Beneficiário: Daniel Fernandes de Andrade
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 19/22113-8 - Solventes eutéticos naturais: síntese, caracterização e aplicações na determinação de As, Cd, Cr, Hg, Se e V em amostras ambientais por ICP-MS
• Beneficiário: Mario Henrique Gonzalez
• Modalidade de apoio: Auxílio à Pesquisa - Regular