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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

dvances Towards the Synthesis of Aporphine Alkaloids: C-Ring Formation via Approaches Based on One- and Two-Bond Disconnection

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Autor(es):
Silva, Tamiris R. C. [1] ; Rita, Bruno H. [1] ; Raminelli, Cristiano [1]
Número total de Autores: 3
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Rua Prof Artur Riedel 275, BR-09972270 Diadema, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo de Revisão
Fonte: CHEMICAL RECORD; v. 22, n. 2 NOV 2021.
Citações Web of Science: 0
Resumo

Aporphine compounds constitute a class of substances with important pharmacological properties, including anticancer, antiviral, anti-HIV, anti-inflammatory, and leishmanicidal activities. Consequently, several strategies to obtain the aporphine core have been reported. Herein this review, we provide an overview of two relevant approaches used to construct the C-ring in the synthetic routes developed. The first approach, which is based on a one-bond disconnection, allows C-ring formation using a 1-benzyl-1,2,3,4-tetrahydroisoquinoline intermediate (mainly) employing cyclization reactions catalyzed by metals or promoted by light. The second approach, which is derived from a two-bond disconnection, leads to C-ring formation via a sequence of reactions starting with {[}4+2] cycloadditions. Through these approaches, aporphinoids with a diverse range of substitution patterns and biological activities can be synthesized. (AU)

Processo FAPESP: 20/12530-8 - 2-(Trimetilsilil)aril trifluorometanossulfonatos como precursores de arinos visando à preparação de compostos (hetero)aromáticos funcionalizados e sínteses de produtos naturais bioativos
Beneficiário:Cristiano Raminelli
Modalidade de apoio: Auxílio à Pesquisa - Regular