The Emergence of the New P.4 Lineage of SARS-CoV-2 With Spike L452R Mutation in Brazil

Autor(es):Mostrar menos -

Bittar, Cintia ^[1] ; Possebon, Fabio Sossai ^[2] ; Ullmann, Leila Sabrina ^[2] ; Geraldini, Dayla Bott ^[1] ; da Costa, Vivaldo G. ^[1] ; de Almeida, Luiz G. P. ^[3] ; Sanches, Paulo Ricardo da S. ^[4] ; Nascimento-Junior, Nailton M. ^[5] ; Cilli, Eduardo M. ^[4] ; Banho, Cecilia Artico ^[6] ; Campos, Guilherme R. F. ^[6] ; Ferreira, Helena Lage ^[7] ; Sacchetto, Livia ^[6] ; da Silva, Gislaine C. D. ^[6] ; Parra, Maisa C. P. ^[6] ; Moraes, Marilia M. ^[6] ; da Costa, Paulo Inacio ^[8] ; Vasconcelos, Ana Tereza R. ^[3] ; Spilki, Fernando Rosado ^[9] ; Nogueira, Mauricio L. ^[6] ; Rahal, Paula ^[1] ; Araujo Jr, Joao Pessoa

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, UNESP, Inst Biociencias Letras & Ciencias Exatas IBILCE, Dept Biol, Lab Estudos Genom, Sao Jose Do Rio Preto - Brazil

^[2] Univ Estadual Paulista, UNESP, Inst Biotecnol, Botucatu, SP - Brazil

^[3] Lab Nacl Comp Cient LNCC, Lab Bioinformat, Petropolis, RJ - Brazil

^[4] Univ Estadual Paulista, UNESP, Lab Sintese & Estudos Biomol LaSEBio, Dept Bioquim & Quim Organ, Inst Quim, Araraquara, SP - Brazil

^[5] Univ Estadual Paulista, UNESP, Laboratdrio Quim Med Sintese Organ & Modelagem Mo, Dept Bioquim & Quim Organ, Inst Quim, Araraquara, SP - Brazil

^[6] Fac Med Sao Jose Rio Preto FAMERP, Dept Doencas Dermatal Infeccioses & Parasitaries, Lab Pesquisas Virol LPV, Sao Jose Do Rio Preto - Brazil

^[7] Univ Sao Paulo, Fac Zootecnia & Engn Alimentos FZEA, Dept Med Vet, Lab Med Vet Prevent Aplicada, Pirassununga - Brazil

^[8] Univ Estadual Paulista, UNESP, Fac Ciencias Farmaceut FCFAR, Dept Analises Clin, Araraquara, SP - Brazil

^[9] Univ Feevale, Inst Ciencias Saude, Lab Microbiol Mol, Novo Hamburgo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN PUBLIC HEALTH; v. 9, OCT 1 2021.
• Citações Web of Science: 0

Resumo

The emergence of several SARS-CoV-2 lineages presenting adaptive mutations is a matter of concern worldwide due to their potential ability to increase transmission and/or evade the immune response. While performing epidemiological and genomic surveillance of SARS-CoV-2 in samples from Porto Ferreira-Sao Paulo-Brazil, we identified sequences classified by pangolin as B.1.1.28 harboring Spike L452R mutation, in the RBD region. Phylogenetic analysis revealed that these sequences grouped into a monophyletic branch, with others from Brazil, mainly from the state of Sao Paulo. The sequences had a set of 15 clade defining amino acid mutations, of which six were in the Spike protein. A new lineage was proposed to Pango and it was accepted and designated P.4. In samples from the city of Porto Ferreira, P.4 lineage has been increasing in frequency since it was first detected in March 2021, corresponding to 34.7% of the samples sequenced in June, the second in prevalence after P.1. Also, it is circulating in 30 cities from the state of Sao Paulo, and it was also detected in one sample from the state of Sergipe and two from the state of Rio de Janeiro. Further studies are needed to understand whether P.4 should be considered a new threat.</p> (AU)

• Processo FAPESP: 20/07419-0 - Estudo clínico e epidemiológico de SARS-CoV-2 em uma coorte prospectiva populacional e hospitalar em São José do Rio Preto, São Paulo, Brasil, durante pandemia de 2020
• Beneficiário: Guilherme Rodrigues Fernandes Campos
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 20/04836-0 - Estudo clínico e epidemiológico de SARS-CoV-2 em uma coorte prospectiva populacional e hospitalar em São José do Rio Preto, São Paulo, Brasil, durante pandemia de 2020
• Beneficiário: Maurício Lacerda Nogueira
• Modalidade de apoio: Auxílio à Pesquisa - Regular