Toward a neurocircuit-based taxonomy to guide treatment of obsessive-compulsive disorder

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Shephard, Elizabeth ^{[1, 2]} ; Stern, Emily R. ^{[3, 4]} ; van den Heuvel, Odile A. ^{[5, 6]} ; Costa, Daniel L. C. ^[1] ; Batistuzzo, Marcelo C. ^[1] ; Godoy, Priscilla B. G. ^[1] ; Lopes, Antonio C. ^[1] ; Brunoni, Andre R. ^[1] ; Hoexter, Marcelo Q. ^[1] ; Shavitt, Roseli G. ^[1] ; Reddy, Y. C. Janardhan ^[7] ; Lochner, Christine ^[8] ; Stein, Dan J. ^{[9, 10]} ; Simpson, H. Blair ^{[11, 12]} ; Miguel, Euripedes C. ^[1]

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^[1] Univ Sao Paulo, Fac Med, Dept Psychiat, Sao Paulo - Brazil

^[2] Kings Coll London, Inst Psychiat Psychol & Neurosci IoPPN, London - England

^[3] NYU, Sch Med, Dept Psychiat, New York, NY - USA

^[4] Nathan S Kline Inst Psychiat Res, Orangeburg, NY - USA

^[5] Vrije Univ Amsterdam, Amsterdam Neurosci, Amsterdam UMC, Dept Psychiat, Amsterdam - Netherlands

^[6] Vrije Univ Amsterdam, Amsterdam Neurosci, Amsterdam UMC, Dept Anat & Neurosci, Amsterdam - Netherlands

^[7] Natl Inst Mental Hlth & Neurosci NIMHANS, Dept Psychiat OCD Clin, Bangalore, Karnataka - India

^[8] Stellenbosch Univ, Dept Psychiat, SA MRC Unit Risk & Resilience Mental Disorders, Cape Town - South Africa

^[9] Univ Cape Town, Dept Psychiat, SA MRC Unit Risk & Resilience Mental Disorders, Cape Town - South Africa

^[10] Univ Cape Town, Neurosci Inst, Cape Town - South Africa

^[11] Columbia Univ, Irving Med Ctr, New York State Psychiat Inst, Ctr OCD & Related Disorders, New York, NY - USA

^[12] Columbia Univ, Dept Psychiat, New York, NY - USA

• Tipo de documento: Artigo de Revisão
• Fonte: MOLECULAR PSYCHIATRY; v. 26, n. 9, p. 4583-4604, SEP 2021.
• Citações Web of Science: 9

Resumo

An important challenge in mental health research is to translate findings from cognitive neuroscience and neuroimaging research into effective treatments that target the neurobiological alterations involved in psychiatric symptoms. To address this challenge, in this review we propose a heuristic neurocircuit-based taxonomy to guide the treatment of obsessive-compulsive disorder (OCD). We do this by integrating information from several sources. First, we provide case vignettes in which patients with OCD describe their symptoms and discuss different clinical profiles in the phenotypic expression of the condition. Second, we link variations in these clinical profiles to underlying neurocircuit dysfunctions, drawing on findings from neuropsychological and neuroimaging studies in OCD. Third, we consider behavioral, pharmacological, and neuromodulatory treatments that could target those specific neurocircuit dysfunctions. Finally, we suggest methods of testing this neurocircuit-based taxonomy as well as important limitations to this approach that should be considered in future research. (AU)

• Processo FAPESP: 18/22396-7 - Uma investigação de neuroimagem multimodal de mudanças nos circuitos neurais durante intervenções precoces para transtornos de neurodesenvolvimento
• Beneficiário: Elizabeth Shephard
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 14/50917-0 - INCT 2014: psiquiatria do desenvolvimento para crianças e adolescentes
• Beneficiário: Eurípedes Constantino Miguel Filho
• Modalidade de apoio: Auxílio à Pesquisa - Temático