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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Toward a neurocircuit-based taxonomy to guide treatment of obsessive-compulsive disorder

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Author(s):
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Shephard, Elizabeth [1, 2] ; Stern, Emily R. [3, 4] ; van den Heuvel, Odile A. [5, 6] ; Costa, Daniel L. C. [1] ; Batistuzzo, Marcelo C. [1] ; Godoy, Priscilla B. G. [1] ; Lopes, Antonio C. [1] ; Brunoni, Andre R. [1] ; Hoexter, Marcelo Q. [1] ; Shavitt, Roseli G. [1] ; Reddy, Y. C. Janardhan [7] ; Lochner, Christine [8] ; Stein, Dan J. [9, 10] ; Simpson, H. Blair [11, 12] ; Miguel, Euripedes C. [1]
Total Authors: 15
Affiliation:
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[1] Univ Sao Paulo, Fac Med, Dept Psychiat, Sao Paulo - Brazil
[2] Kings Coll London, Inst Psychiat Psychol & Neurosci IoPPN, London - England
[3] NYU, Sch Med, Dept Psychiat, New York, NY - USA
[4] Nathan S Kline Inst Psychiat Res, Orangeburg, NY - USA
[5] Vrije Univ Amsterdam, Amsterdam Neurosci, Amsterdam UMC, Dept Psychiat, Amsterdam - Netherlands
[6] Vrije Univ Amsterdam, Amsterdam Neurosci, Amsterdam UMC, Dept Anat & Neurosci, Amsterdam - Netherlands
[7] Natl Inst Mental Hlth & Neurosci NIMHANS, Dept Psychiat OCD Clin, Bangalore, Karnataka - India
[8] Stellenbosch Univ, Dept Psychiat, SA MRC Unit Risk & Resilience Mental Disorders, Cape Town - South Africa
[9] Univ Cape Town, Dept Psychiat, SA MRC Unit Risk & Resilience Mental Disorders, Cape Town - South Africa
[10] Univ Cape Town, Neurosci Inst, Cape Town - South Africa
[11] Columbia Univ, Irving Med Ctr, New York State Psychiat Inst, Ctr OCD & Related Disorders, New York, NY - USA
[12] Columbia Univ, Dept Psychiat, New York, NY - USA
Total Affiliations: 12
Document type: Review article
Source: MOLECULAR PSYCHIATRY; v. 26, n. 9, p. 4583-4604, SEP 2021.
Web of Science Citations: 9
Abstract

An important challenge in mental health research is to translate findings from cognitive neuroscience and neuroimaging research into effective treatments that target the neurobiological alterations involved in psychiatric symptoms. To address this challenge, in this review we propose a heuristic neurocircuit-based taxonomy to guide the treatment of obsessive-compulsive disorder (OCD). We do this by integrating information from several sources. First, we provide case vignettes in which patients with OCD describe their symptoms and discuss different clinical profiles in the phenotypic expression of the condition. Second, we link variations in these clinical profiles to underlying neurocircuit dysfunctions, drawing on findings from neuropsychological and neuroimaging studies in OCD. Third, we consider behavioral, pharmacological, and neuromodulatory treatments that could target those specific neurocircuit dysfunctions. Finally, we suggest methods of testing this neurocircuit-based taxonomy as well as important limitations to this approach that should be considered in future research. (AU)

FAPESP's process: 18/22396-7 - A multimodal neuroimaging investigation of changes in neural circuitry during early interventions for neurodevelopmental disorders
Grantee:Elizabeth Shephard
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 14/50917-0 - INCT 2014: developmental psychiatry for children and adolescents
Grantee:Eurípedes Constantino Miguel Filho
Support Opportunities: Research Projects - Thematic Grants