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Alterations in the inflammatory pathway of Cox: risk for the development of schizophrenia

Grant number: 18/11414-4
Support type:Scholarships in Brazil - Master
Effective date (Start): October 01, 2018
Effective date (End): August 31, 2020
Field of knowledge:Biological Sciences - Immunology - Cellular Immunology
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Wagner Farid Gattaz
Grantee:Cícero Augusto Costa Pereira
Home Institution: Instituto de Psiquiatria Doutor Antonio Carlos Pacheco e Silva (IPq). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil


Schizophrenia is a psychiatric disease that affects around 1% of the world's population, and comprises a number of heterogeneous symptoms complicating treatment. Above all, several environmental and genetic factors influence its etiology and, therefore, diagnosing the disease before it manifests itself is a further step towards treatment, characterizing this group in UHR (ultra high risk), a prodrome profile of the disease that may or may not to manifest. The interest in this group is to find biological markers that can predict the disease and increasingly understand its etiology, so researchers study the inflammatory processes in schizophrenia and have already noticed the irregular presence of some cytokines. Our interest is to find peripheral biomarkers that guide us to identify processes that are compromised by the etiology of the disease, the inflammatory process during the disease period seems to be compromised and our study will study the inflammatory pathway of COX-2, this is a pathway induced by other inflammatory processes such as cytokines and we will associate these inflammatory markers between them and analyze them in UHR and converted schizophrenic patients.The methodology to be performed will be a lipid metabolomics used for analysis of the COX-2 pathway and made through a mass spectrometer associated to liquid chromatography identifying our target markers, an extremely specific technique with great sensitivity for detection of molecules. And together we will do the immunofluorescence technique of COX-2-related cytokines to quantify specific cytokines and see interactions of both inflammatory markers if it is altered both in the prodromal phase and in the phase of psychotic disorders.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TALIB, LEDA L.; COSTA, ALANA C.; JOAQUIM, HELENA P. G.; PEREIRA, CICERO A. C.; VAN DE BILT, MARTINUS T.; LOCH, ALEXANDRE A.; GATTAZ, WAGNER F. Increased PLA(2) activity in individuals at ultra-high risk for psychosis. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, v. 271, n. 8, p. 1593-1599, DEC 2021. Web of Science Citations: 0.
JOAQUIM, HELENA P. G.; COSTA, ALANA C.; PEREIRA, CICERO A. C.; TALIB, LEDA L.; BILT, V, MARTINUS M.; LOCH, ALEXANDRE A.; GATTAZ, WAGNER F. lasmatic endocannabinoids are decreased in subjects with ultra-high risk of psychosi. European Journal of Neuroscience, v. 55, n. 4, SI NOV 2021. Web of Science Citations: 1.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
PEREIRA, Cícero Augusto Costa. Inflammatory mediators in prodrome psychosis as potentials biomarkers. 2021. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.

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