A New Curcuminoids-Coumarin Derivative: Mechanochemical Synthesis, Characterization and Evaluation of Its In Vitro Cytotoxicity and Antimicrobial Properties

Autor(es)

de Moura, Aniele ^[1] ; Gaglieri, Caroline ^[1] ; Alarcon, Rafael Turra ^[1] ; Ferreira, Laura Teofilo ^[2] ; Vecchi, Rafael ^[3] ; Rovis Sanches, Mariana Liessa ^[4] ; de Oliveira, Rodrigo Cardoso ^[4] ; Venturini, James ^{[3, 5]} ; da Silva-Filho, Luiz Carlos ^[1] ; Caires, Flavio Junior ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, UNESP, Chem Dept, Sch Sci, BR-17033260 Bauru, SP - Brazil

^[2] UNESP Sao Paulo State Univ, Inst Chem, BR-14800900 Araraquara, SP - Brazil

^[3] UNESP Sao Paulo State Univ, Trop Dis & Imaging Diag, Med Sch, BR-18618687 Botucatu, SP - Brazil

^[4] Univ Sao Paulo, Dept Biol Sci, Bauru Sch Dent, BR-17011220 Bauru, SP - Brazil

^[5] UFMS Mato Grosso do Sul Fed Univ, Med Sch, BR-79070900 Campo Grande, MS - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CHEMISTRYSELECT; v. 6, n. 41, p. 11352-11361, NOV 8 2021.
• Citações Web of Science: 0

Resumo

Over the years, several drugs have been developed deriving from plants to investigate possible therapeutic roles. Among them, curcuminoids and coumarins, which, display a wide range of biological activity against several strains. Therefore, it was synthesized a curcuminoids-coumarin derivative by a mechanochemical multicomponent reaction. By NMR and HRMS results confirmed the formation of a mixture of three curcuminoids-coumarin derivatives in the same sample. The Influence of time during the milling process was evaluated, resulting in a crystalline product in only 30 min. The LAG milling carried out with different solvents showed that the product is obtained regardless of the solvent polarity. Furthermore, the biological evaluation showed that the curcuminoids-coumarin derivative has better activity against S. aureus than curcumin and 4-hydroxycoumarin. Lastly, the cell viability study exhibited a decrease of cytotoxicity of the derivative, compared to curcumin, against NIH3T3 cells. (AU)

• Processo FAPESP: 13/07296-2 - CDMF - Centro de Desenvolvimento de Materiais Funcionais
• Beneficiário: Elson Longo da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 18/03460-6 - Modificação estrutural de triglicerídeos visando a obtenção de novos monômeros e polímeros por diferentes rotas sintéticas: irradiação de micro-ondas e fotopolimerização
• Beneficiário: Rafael Turra Alarcon
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/14506-7 - Estudo sobre a síntese "one-pot" e aplicação como corantes orgânicos de derivados quinolínicos e antrazolínicos
• Beneficiário: Luiz Carlos da Silva Filho
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/24378-6 - Síntese, caracterização e estudo termoanalítico de cocristais de Valsartana, Candesartana Cilexetila e Olmesartana medoxomila
• Beneficiário: Flávio Junior Caires
• Modalidade de apoio: Auxílio à Pesquisa - Regular