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The Impact of ACTN3 Gene Polymorphisms on Susceptibility to Exercise-Induced Muscle Damage and Changes in Running Economy Following Downhill Running

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Autor(es):
de Lima, Leonardo Coelho Rabello [1, 2, 3] ; Bueno Junior, Carlos Roberto [4] ; de Oliveira Assumpcao, Claudio [5, 1] ; de Menezes Bassan, Natalia [1] ; Barreto, Renan Vieira [1] ; Cardozo, Adalgiso Coscrato [6] ; Greco, Camila Coelho [1] ; Denadai, Benedito Sergio [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ, Dept Phys Educ, Human Performance Lab, Rio Claro - Brazil
[2] Ctr Univ Fundacao Herminio Ometto, Sch Phys Educ, Fac Biol & Hlth Sci, Araras - Brazil
[3] Ctr Univ Salesiano Sao Paulo, Sch Phys Educ, Campus Liceu Salesiano, Campinas - Brazil
[4] Univ Sao Paulo, Sch Phys Educ & Sport, Ribeirao Preto - Brazil
[5] Univ Fed Ceara, Phys Educ & Sports Inst, Fortaleza, Ceara - Brazil
[6] Sao Paulo State Univ, Dept Phys Educ, Biomech Lab, Rio Claro - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: FRONTIERS IN PHYSIOLOGY; v. 12, NOV 15 2021.
Citações Web of Science: 0
Resumo

This study aimed to investigate if ACTN3 gene polymorphism impacts the susceptibility to exercise-induced muscle damage (EIMD) and changes in running economy (RE) following downhill running. Thirty-five healthy men were allocated to the two groups based on their ACTN3 gene variants: RR and X allele carriers. Neuromuscular function {[}knee extensor isometric peak torque (IPT), rate of torque development (RTD), and countermovement, and squat jump height], indirect markers of EIMD {[}muscle soreness, mid-thigh circumference, knee joint range of motion, and serum creatine kinase (CK) activity], and RE (oxygen uptake, minute ventilation, blood lactate concentration, and perceived exertion) for 5-min of running at a speed equivalent to 80% of individual maximal oxygen uptake speed were assessed before, immediately after, and 1-4 days after a 30-min downhill run (-15%). Neuromuscular function was compromised (P < 0.05) following downhill running with no differences between the groups, except for IPT, which was more affected in the RR individuals compared with the X allele carriers immediately (-24.9 +/- 6.9% vs. -16.3 +/- 6.5%, respectively) and 4 days (-16.6 +/- 14.9% vs. -4.2 +/- 9.5%, respectively) post-downhill running. EIMD manifested similarly for both the groups except for serum CK activity, which was greater for RR (398 +/- 120 and 452 +/- 126 U L-1 at 2 and 4 days following downhill running, respectively) compared with the X allele carriers (273 +/- 121 and 352 +/- 114 U L-1 at the same time points). RE was compromised following downhill running (16.7 +/- 8.3% and 11 +/- 7.5% increases in oxygen uptake immediately following downhill running for the RR and X allele carriers, respectively) with no difference between the groups. We conclude that although RR individuals appear to be more susceptible to EIMD following downhill running, this does not extend to the changes in RE. (AU)

Processo FAPESP: 21/12609-6 - O impacto dos polimorfismos do gene ACTN3 na susceptibilidade ao dano muscular e alterações na economia de corrida induzidos por uma sessão de corrida em declive
Beneficiário:Leonardo Coelho Rabello de Lima
Modalidade de apoio: Auxílio à Pesquisa - Publicações científicas - Artigo
Processo FAPESP: 13/23585-4 - Relação entre economia de corrida e força muscular: Análise pelo modelo de dano muscular induzido pela corrida em declive
Beneficiário:Leonardo Coelho Rabello de Lima
Modalidade de apoio: Bolsas no Brasil - Doutorado