| Full text | |
| Author(s): |
de Lima, Leonardo Coelho Rabello
[1, 2, 3]
;
Bueno Junior, Carlos Roberto
[4]
;
de Oliveira Assumpcao, Claudio
[5, 1]
;
de Menezes Bassan, Natalia
[1]
;
Barreto, Renan Vieira
[1]
;
Cardozo, Adalgiso Coscrato
[6]
;
Greco, Camila Coelho
[1]
;
Denadai, Benedito Sergio
[1]
Total Authors: 8
|
| Affiliation: | [1] Sao Paulo State Univ, Dept Phys Educ, Human Performance Lab, Rio Claro - Brazil
[2] Ctr Univ Fundacao Herminio Ometto, Sch Phys Educ, Fac Biol & Hlth Sci, Araras - Brazil
[3] Ctr Univ Salesiano Sao Paulo, Sch Phys Educ, Campus Liceu Salesiano, Campinas - Brazil
[4] Univ Sao Paulo, Sch Phys Educ & Sport, Ribeirao Preto - Brazil
[5] Univ Fed Ceara, Phys Educ & Sports Inst, Fortaleza, Ceara - Brazil
[6] Sao Paulo State Univ, Dept Phys Educ, Biomech Lab, Rio Claro - Brazil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | FRONTIERS IN PHYSIOLOGY; v. 12, NOV 15 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
This study aimed to investigate if ACTN3 gene polymorphism impacts the susceptibility to exercise-induced muscle damage (EIMD) and changes in running economy (RE) following downhill running. Thirty-five healthy men were allocated to the two groups based on their ACTN3 gene variants: RR and X allele carriers. Neuromuscular function {[}knee extensor isometric peak torque (IPT), rate of torque development (RTD), and countermovement, and squat jump height], indirect markers of EIMD {[}muscle soreness, mid-thigh circumference, knee joint range of motion, and serum creatine kinase (CK) activity], and RE (oxygen uptake, minute ventilation, blood lactate concentration, and perceived exertion) for 5-min of running at a speed equivalent to 80% of individual maximal oxygen uptake speed were assessed before, immediately after, and 1-4 days after a 30-min downhill run (-15%). Neuromuscular function was compromised (P < 0.05) following downhill running with no differences between the groups, except for IPT, which was more affected in the RR individuals compared with the X allele carriers immediately (-24.9 +/- 6.9% vs. -16.3 +/- 6.5%, respectively) and 4 days (-16.6 +/- 14.9% vs. -4.2 +/- 9.5%, respectively) post-downhill running. EIMD manifested similarly for both the groups except for serum CK activity, which was greater for RR (398 +/- 120 and 452 +/- 126 U L-1 at 2 and 4 days following downhill running, respectively) compared with the X allele carriers (273 +/- 121 and 352 +/- 114 U L-1 at the same time points). RE was compromised following downhill running (16.7 +/- 8.3% and 11 +/- 7.5% increases in oxygen uptake immediately following downhill running for the RR and X allele carriers, respectively) with no difference between the groups. We conclude that although RR individuals appear to be more susceptible to EIMD following downhill running, this does not extend to the changes in RE. (AU) | |
| FAPESP's process: | 13/23585-4 - The relationship between running economy and strength: Utilizing a downhill runnin-induced muscle damage analysis model. |
| Grantee: | Leonardo Coelho Rabello de Lima |
| Support Opportunities: | Scholarships in Brazil - Doctorate |