Combined effects of theta-burst stimulation with transcranial direct current stimulation of the prefrontal cortex: study protocol of a randomized, double-blinded, sham-controlled trial using Tc-99m-ECD SPECT

Autor(es)

Razza, Lais B. ^[1] ; Buchpiguel, Carlos A. ^[2] ; De Smet, Stefanie ^{[3, 4]} ; Klein, Izio ^[1] ; Baeken, Chris ^{[5, 3, 4]} ; Galhardoni, Ricardo ^{[6, 7]} ; Vanderhasselt, Marie-Anne ^{[5, 3, 4]} ; Brunoni, Andre R. ^{[8, 2, 1, 9]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Dept & Inst Psiquiatria, Hosp Clin, Serv Interdisciplinar Neuromodulacao, Lab Neurocie, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Fac Med, Dept Med Interna, Sao Paulo, SP - Brazil

^[3] Ghent Expt Psychiat GHEP Lab, Ghent - Belgium

^[4] Univ Ghent, Ghent Univ Hosp, Dept Head & Skin Psychiat & Med Psychol, Ghent - Belgium

^[5] Univ Ghent, Dept Expt Clin & Hlth Psychol, Ghent - Belgium

^[6] Univ Cidade Sao Paulo UNICID, Escola Med, Sao Paulo - Brazil

^[7] Univ Sao Paulo, Dept Neurol, Ctr Dor, LIM 62, Sao Paulo, SP - Brazil

^[8] Univ Sao Paulo, Univ Hosp, Sao Paulo, SP - Brazil

^[9] Univ Sao Paulo, Fac Med, Inst Nacl Biomarcadores Neuropsiquiatria INBioN, Dept & Inst Psiquiatria, LIM 27, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Trends in Psychiatry and Psychotherapy; v. 43, n. 4, p. 293-301, OCT-DEC 2021.
• Citações Web of Science: 1

Resumo

Introduction: Non-invasive brain stimulation (NIBS) as monotherapy has been increasingly used to enhance the activity of brain networks. However, it is unclear whether a combination of distinct NIBS approaches could enhance prefrontal cortical (PFC) activity. Objective: We propose to investigate the combined and standalone effects of two NIBS modalities on the PFC through a working memory task, single photon emission computed tomography (SPECT), and salivary cortisol. We hypothesize that the combined protocol will provoke greater changes in the collected measures compared to the remining protocols. Methods: A randomized, double-blind, sham-controlled, full-factorial design will be conducted. The effects of transcranial direct current stimulation (tDCS) and intermittent theta-burst stimulation (iTBS) will be investigated over four different sessions (sham tDCS + sham iTBS, anodal tDCS + sham iTBS, anodal tDCS + active iTBS and sham tDCS + active iTBS) in 30 healthy adult volunteers. A 99mTc-ethylene cysteine dimer (99mTC-ECD) will be administered during the NIBS session and neuroimaging will be acquired within one hour. Salivary cortisol will be collected before and after each session and an n-back working memory task will be applied after the end of each NIBS session. The outcomes will be cerebral perfusion alterations (99mTC-ECD SPECT), accuracy and reaction time in the n-back task, and changes in salivary cortisol level. Conclusion: The results from this trial can guide future therapeutic protocols for NIBS treatments stimulating the PFC by demonstrating that the combination of NIBS techniques is feasible, tolerable, and can lead to greater enhancement of PFC activity. (AU)

• Processo FAPESP: 19/07256-7 - Alterações na perfusão cerebral induzidas por estimulação transcraniana do córtex pré-frontal: um estudo randomizado, placebo-controlado utilizando 99mTc SPECT
• Beneficiário: Lais Boralli Razza
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 18/10861-7 - Avaliação multimodal dos efeitos da estimulação transcraniana por corrente contínua e estimulação theta-burst no funcionamento do córtex pré-frontal: um estudo Fase-I bilateral, placebo-controlado, fatorial
• Beneficiário: Andre Russowsky Brunoni
• Modalidade de apoio: Auxílio à Pesquisa - Regular