Role of Iron Phthalocyanine Coordination in Catecholamines Detection

Autor(es)

Martin, Cibely S. ^[1] ; Rubira, Rafael J. G. ^[1] ; Silva, Jaqueline N. ^[1] ; Alessio, Priscila ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Sch Technol & Appl Sci, BR-19060080 Presidente Prudente, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SURFACES; v. 4, n. 4, p. 323-335, DEC 2021.
• Citações Web of Science: 0

Resumo

Catecholamines are an important class of neurotransmitters responsible for regularizing, controlling, and treating neural diseases. Based on control and diseases treatment, the development of methodology and dives to sensing is a promissory technology area. This work evaluated the role of iron phthalocyanine coordination (FePc) with the specific groups from catecholamine molecules (L-dopa, dopamine, epinephrine, and the amino acid tyrosine) and the effect of this coordination on electrochemical behavior. The in situ coordination analysis was performed through isotherms pi-A of FePc Langmuir films in the absence and presence of catecholamines. The pi-A isotherm indicates a strong interaction between FePc monolayer and L-Dopa and DA, which present a catechol group and a side chain with a protonated amino group (-NH3+). These strong interactions with catechol and amine groups were confirmed by characterization at the molecular level using the surface-enhanced Raman spectroscopy (SERS) from a Langmuir-Schaefer monolayer deposited onto Ag surfaces. The electrochemical measurements present a similar tendency, with lower oxidation potential observed to DA>L-Dopa>Ep. The results corroborate that the coordination of the analyte on the electron mediator surface plays an essential role in an electrochemical sensing application. The FePc LS film was applied as a sensor in tablet drug samples, showing a uniformity of content of 96% for detecting active compounds present in the L-Dopa drug samples. (AU)

• Processo FAPESP: 17/15019-0 - Combinação das técnicas de microscopia de fluorescência confocal e espalhamento micro-Raman amplificado em superfície (SERS): interação, detecção e quantificação de moléculas de interesse em sistemas biomiméticos.
• Beneficiário: Cibely da Silva Martin Sonvesso
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 14/50869-6 - INCT 2014: em Eletrônica Orgânica INEO
• Beneficiário: Roberto Mendonça Faria
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 17/06534-8 - O Impacto de Poluentes Emergentes na Saúde: um Estudo em Membranas Biomiméticas
• Beneficiário: Priscila Alessio Constantino
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 20/05423-0 - Detecção de agrotóxicos (coquetel) utilizados nas lavouras de cana-de-açúcar e o efeito destes sobre sistemas biológicos
• Beneficiário: Rafael Jesus Gonçalves Rubira
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado