Ability of a Combined FIB4/miRNA181a Score to Predict Significant Liver Fibrosis in NAFLD Patients

Autor(es)

Lima, Rodrigo Vieira Costa ^[1] ; Stefano, Jose Tadeu ^[1] ; Malta, Fernanda de Mello ^[1] ; Pinho, Joao Renato Rebello ^[1] ; Carrilho, Flair Jose ^[1] ; Arrese, Marco ^{[2, 3]} ; Oliveira, Claudia P. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Lab Gastroenterol Clin & Expt LIM 07, Div Clin Gastroenterol & Hepat, Dept Gastroenterol, Hosp Clin HCFMUSP, Fac Med, BR-05403000 Sao Paulo, SP - Brazil

^[2] Pontificia Univ Catolica Chile, Escuela Med, Dept Gastroenterol, Santiago 8330024 - Chile

^[3] Pontificia Univ Catolica Chile, Fac Ciencias Biol, Dept Biol Celular & Mol, Ctr Envejecimiento & Regenerac CARE, Santiago 8330024 - Chile

• Tipo de documento: Artigo Científico
• Fonte: BIOMEDICINES; v. 9, n. 12 DEC 2021.
• Citações Web of Science: 0

Resumo

Liver biopsy is the gold standard for assessing fibrosis, but there is a need to seek non-invasive biomarkers for this purpose. The aim of this study was to evaluate the correlation between the serum levels of the microRNAs miR-21, miR-29a, miR-122, miR-155 and miR-181a and the phenotypic expression of NAFLD. A cross-sectional study was carried out on 108 NAFLD patients diagnosed by liver biopsy. FIB-4 and NAFLD fibrosis scores were calculated. The comparison between the distributions of microRNA values according to the presence or absence of histological fibrosis (F2-F4) was performed. A multivariate logistic regression analysis was performed to build a score for predicting fibrosis using FIB-4 and Ln (miR-181a) as independent variables. Only miR-181a showed a statistical difference between patients with significant liver fibrosis (>F2) and those without (F0-F1) (p = 0.017). FIB-4 revealed an AUC on the ROC curve of 0.667 to predict clinically significant fibrosis (F2-F4). When assessed using the score in association with Ln (miR-181a), there was an improvement in the ROC curve, with an AUC of 0.71. miR-181a can be used as a non-invasive method of predicting fibrosis in NAFLD, and an association with FIB-4 has the potential to increase the accuracy of each method alone. (AU)

• Processo FAPESP: 18/03698-2 - PAPEL DOS MICRO-RNAs NA EXPRESSÃO FENOTÍPICA DA DOENÇA HEPÁTICA GORDUROSA NÃO ALCOÓLICA: DA ESTEATOSE AO CARCINOMA HEPATOCELULAR
• Beneficiário: Claudia Pinto Marques Souza de Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular